2. Metabolic Enzyme/Protease
  3. Dipeptidyl Peptidase
  4. 5-Hydroxy saxagliptin hydrochloride

5-Hydroxy saxagliptin hydrochloride is an active metabolite of Saxagliptin (HY-10285) and a potent and selective DPP-4 inhibitor. 5-Hydroxy saxagliptin hydrochloride has Ki values of 2.6 nM and 2.9 nM for humans and cynomolgus monkeys, respectively. 5-Hydroxy saxagliptin hydrochloride can be used in the research of type 2 diabetes mellitus.

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5-Hydroxy saxagliptin hydrochloride Chemical Structure

5-Hydroxy saxagliptin hydrochloride Chemical Structure

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5-Hydroxy saxagliptin hydrochloride Related Antibodies

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Description

5-Hydroxy saxagliptin hydrochloride is an active metabolite of Saxagliptin (HY-10285) and a potent and selective DPP-4 inhibitor. 5-Hydroxy saxagliptin hydrochloride has Ki values of 2.6 nM and 2.9 nM for humans and cynomolgus monkeys, respectively. 5-Hydroxy saxagliptin hydrochloride can be used in the research of type 2 diabetes mellitus[1].

IC50 & Target[1]

DPP-4

2.6 nM (Ki)

DPP-8

2495 nM (Ki)

DPP-9

423 nM (Ki)

Molecular Weight

367.87

Formula

C18H26ClN3O3
SMILES

O[C@@]1(C2)C[C@@]3([C@@H](C(N4[C@H](C#N)C[C@H]5[C@@H]4C5)=O)N)C[C@@](C[C@@H]2C3)(O)C1.Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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5-Hydroxy saxagliptin hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5-Hydroxy saxagliptinDipeptidyl PeptidaseDPPSaxagliptincynomolgus monkeystype 2 diabetes mellitusInhibitorinhibitorinhibit

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5-Hydroxy saxagliptin hydrochloride
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HY-W741755A
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