CD20/MS4A1 Protein-VLP, Dog (HEK293, His)

CD20/MS4A1 Protein-VLP, Dog (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.

The CD20/MS4A1 Protein-VLP, Dog, serves as a B-lymphocyte-specific membrane protein, pivotal in regulating cellular calcium influx essential for the development, differentiation, and activation of B-lymphocytes. Operating as a store-operated calcium (SOC) channel component, it facilitates calcium influx upon activation by the B-cell receptor/BCR. The protein forms homotetramers, contributing to its structural organization and functional role in calcium signaling. An integral part of the B-cell receptor complex, CD20/MS4A1 Protein-VLP, Dog, interacts specifically with the heavy and light chains of cell surface IgM, representing the antigen-binding components of the BCR. This interaction highlights its crucial role in B-cell activation and underscores its significance in the orchestration of immune responses.

Dog

HEK293

C-10*His

Q3C2E2 (M1-P297)

485430  [NCBI]

Full Length

MTTPRNSMSGTLPVDPMKSPTAMYPVQKIIPKRMPSVVGPTQNFFMRESKTLGAVQIMNGLFHIALGSLLMIHTDVCAPICITMWYPLWGGIMFIISGSLLAAADKNPRKSLVKGKMIMNSLSLFAAISGIIFLIMDIFNITISHFFKMENLNLIKAPMPYVDIHNCDPANPSEKNSLSIQYCGSIRSVFLGVFAVMLIFAFFQKLVTAGIVENEWKKLCSKPKSDVVVLLAAEEKKEQPIETTEEMVELTEIASQPKKEEDIEIIPVQEEEGELEINFAEPPQEQESSPIENDSIP

Greater than 80% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.