Myristoyl pentapeptide-4

Name: Myristoyl pentapeptide-4
Brand: MedChemExpress
SKU: HY-P5239
Rating: 4.5 (1 reviews)

Cat. No.: HY-P5239 Purity: 98.86%: Data Sheet
SDS

COA
Handling Instructions
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Technical Support

Myristoyl pentapeptide-4 is a bioactive peptide with promotion of hair growth effect and has been reported used as a cosmetic ingredient.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Myristoyl pentapeptide-4 Chemical Structure

CAS No. : 1392416-25-9

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Myristoyl pentapeptide-4 is a bioactive peptide with promotion of hair growth effect and has been reported used as a cosmetic ingredient^[1].

In Vitro

Myristoyl pentapeptide-4 is a synthetic peptide composed of five amino acids with the sequence Lys-Thr-Thr-Lys-Ser (KTTKS)^[1].
Myristoyl pentapeptide-4 (10-40 μM, 48 h) specifically targets keratin, activates the transcription and translation of keratin genes, promotes the synthesis of keratin, thereby improving the elasticity and strength of hair^[1].
Myristoyl pentapeptide-4 (0-25 μM, 24 h) promotes the proliferation of HaCaT, stimulates the migration of human hair follicle papilla cells (HDPCs)^[1].
Myristoyl pentapeptide-4 stimulates skin fibroblasts to produce collagen and fibronectin, thereby reducing wrinkles and improving skin elasticity. Myristoyl pentapeptide-4 also promotes wound healing and skin repair^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	HaCaT
Concentration:	0-25 μM
Incubation Time:	24 h
Result:	Improved the cell viability.

In Vivo

Myristoyl pentapeptide-4 (500 μL, topical application, once daily for 21 days) increases the the number of hair follicles, and promotes the hair growth in mouse androgenic alopecia models.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Testosterone induced mouse androgenic alopecia (AGA) model^[1]
Dosage:	500 μL, the concentration remains unknown, but is related to the concentration range in vitro experiments
Administration:	topical application, once daily for 21 days
Result:	Increasede the the number of hair follicles, and promoted the hair growth.

Molecular Weight

774.00

Formula

C₃₇H₇₁N₇O₁₀

CAS No.

1392416-25-9

Appearance

Solid

Color

White to off-white

Sequence

{Myr-Lys}-Thr-Thr-Lys-Ser

Sequence Shortening

{Myr-Lys}-TTKS

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (161.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2920 mL	6.4599 mL	12.9199 mL
5 mM	0.2584 mL	1.2920 mL	2.5840 mL
10 mM	0.1292 mL	0.6460 mL	1.2920 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.86%

Select Batch:

Data Sheet (270 KB) SDS (252 KB)

COA (243 KB) HNMR (321 KB) LCMS (90 KB)

Handling Instructions (2659 KB)

References

[1]. Li-Wei Tian, et al. Co-delivery of bioactive peptides by nanoliposomes for promotion of hair growth. Journal of Drug Delivery Science and Technology Volume 72, June 2022, 103381

[2]. Ngoc L T N, et al., Insights into bioactive peptides in cosmetics[J]. Cosmetics, 2023, 10(4): 111.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.2920 mL	6.4599 mL	12.9199 mL	32.2997 mL
	5 mM	0.2584 mL	1.2920 mL	2.5840 mL	6.4599 mL
	10 mM	0.1292 mL	0.6460 mL	1.2920 mL	3.2300 mL
	15 mM	0.0861 mL	0.4307 mL	0.8613 mL	2.1533 mL
	20 mM	0.0646 mL	0.3230 mL	0.6460 mL	1.6150 mL
	25 mM	0.0517 mL	0.2584 mL	0.5168 mL	1.2920 mL
	30 mM	0.0431 mL	0.2153 mL	0.4307 mL	1.0767 mL
	40 mM	0.0323 mL	0.1615 mL	0.3230 mL	0.8075 mL
	50 mM	0.0258 mL	0.1292 mL	0.2584 mL	0.6460 mL
	60 mM	0.0215 mL	0.1077 mL	0.2153 mL	0.5383 mL
	80 mM	0.0161 mL	0.0807 mL	0.1615 mL	0.4037 mL
	100 mM	0.0129 mL	0.0646 mL	0.1292 mL	0.3230 mL