4-Desmethoxy Omeprazole

Cat. No.: HY-135111 Purity: 98.99%: Data Sheet
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4-Desmethoxy Omeprazole is the active metabolite of Omeprazole. Omeprazole, a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a K_i of 2 to 6 μM. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria.

For research use only. We do not sell to patients.

4-Desmethoxy Omeprazole Chemical Structure

CAS No. : 110374-16-8

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of 4-Desmethoxy Omeprazole:

4-Desmethoxy Omeprazole-d₃ Get quote
4-Desmethoxy Omeprazole (Standard) Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

4-Desmethoxy Omeprazole is the active metabolite of Omeprazole. Omeprazole, a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a K_i of 2 to 6 μM^[1]. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria^[2].

Molecular Weight

315.39

Formula

C₁₆H₁₇N₃O₂S

CAS No.

110374-16-8

Appearance

Powder

Color

white

SMILES

COC1=CC=C2N=C(S(CC3=NC=C(C)C=C3C)=O)NC2=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (396.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1707 mL	15.8534 mL	31.7068 mL
5 mM	0.6341 mL	3.1707 mL	6.3414 mL
10 mM	0.3171 mL	1.5853 mL	3.1707 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Purity & Documentation

Purity: 98.99%

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Data Sheet (269 KB) SDS (597 KB)

COA (246 KB) HNMR (248 KB) LCMS (100 KB)

Handling Instructions (2659 KB)

References

[1]. Li XQ, et al. Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities. Drug Metab Dispos. 2004 Aug;32(8):821-7. [Content Brief]

[2]. Jonkers D, et al. Omeprazole inhibits growth of gram-positive and gram-negative bacteria including Helicobacter pylori in vitro. J Antimicrob Chemother. 1996 Jan;37(1):145-50. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.1707 mL	15.8534 mL	31.7068 mL	79.2669 mL
	5 mM	0.6341 mL	3.1707 mL	6.3414 mL	15.8534 mL
	10 mM	0.3171 mL	1.5853 mL	3.1707 mL	7.9267 mL
	15 mM	0.2114 mL	1.0569 mL	2.1138 mL	5.2845 mL
	20 mM	0.1585 mL	0.7927 mL	1.5853 mL	3.9633 mL
	25 mM	0.1268 mL	0.6341 mL	1.2683 mL	3.1707 mL
	30 mM	0.1057 mL	0.5284 mL	1.0569 mL	2.6422 mL
	40 mM	0.0793 mL	0.3963 mL	0.7927 mL	1.9817 mL
	50 mM	0.0634 mL	0.3171 mL	0.6341 mL	1.5853 mL
	60 mM	0.0528 mL	0.2642 mL	0.5284 mL	1.3211 mL
	80 mM	0.0396 mL	0.1982 mL	0.3963 mL	0.9908 mL
	100 mM	0.0317 mL	0.1585 mL	0.3171 mL	0.7927 mL