Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2)

Cat. No.: HY-P990144 Purity: 95.00%: Data Sheet
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Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2) is an anti-mouse/human VLA-4/CD49d IgG2b monoclonal antibody. Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2) can reduce VLA-4 positive cells. Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2) can inhibit the migration of Tc1 cells to tumors. Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2) inhibits the retention of leukemia cells in the spleen and bone marrow by blocking VLA-4. Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2) can be used for research on inflammation conditions and cancer such as experimental autoimmune encephalomyelitis (EAE), melanoma and leukemia.

For research use only. We do not sell to patients.

Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2) Chemical Structure

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2) Featured Recommendations:

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

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αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

Biological Activity
Purity & Documentation
References
Customer Review

Description

Isotype

Rat IgG2b kappa

Recommend Isotype Controls

Rat IgG2b kappa, Isotype Control

Species Reactivity

Human/Mouse

IC₅₀ & Target^[1]^[2]^[3]

α4β1

In Vitro

Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2) (20 μg/mL, 15 min) significantly inhibits the adhesion of Tc1 cells to VCAM-1^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2) (0.1 mg, i.p., once every other day, from day 4 to day 14) significantly reduces the incidence of diseases in female BALB/c mice with a virus induced experimental autoimmune encephalomyelitis (EAE) model^[1].
Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2) (150 μg, i.v., single dose) significantly inhibits the migration of Tc1 cells to intracranial tumors in C57BL/6 mice bearing M05 tumors^[2].
Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2) (10 mg/kg, i.p., twice a week, for 5 weeks) significantly reduces tumor cells in the spleen and bone marrow in wild type C57BL/6J mice with a chronic lymphocytic leukemia (CLL) model^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	1×10⁶ PFU SFV-A7 virus induced female BALB/c mice (6-8 weeks)^[1]
Dosage:	0.1 mg
Administration:	Intraperitoneal injection (i.p.), once every other day, from day 4 to day 14
Result:	Significantly reduced the incidence rate to 10 % and the average incidence day to 14.0 days. Significantly reduced inflammation and some mouse brain tissues were completely free of inflammation. Reduced VCAM-1 expression and decreased VLA-4 positive cells.

Animal Model:	5×10⁴ M05 cells injected C57BL/6 mice (5-9 weeks)^[2]
Dosage:	150 μg
Administration:	Intravenous injection (i.v.), single dose
Result:	Significantly inhibited the migration of Tc1 cells (inhibition of 85 %).

Animal Model:	5×10⁶ splenocytes from TCL1-tg mouse injected wild type C57BL/6J mice^[3]
Dosage:	10 mg/kg
Administration:	Intraperitoneal injection (i.p.), twice a week, for 5 weeks
Result:	Reduced the number of tumor cells in the spleen and bone marrow. Reduced peripheral blood leukemia cells.

Gene ID

16401 [NCBI]

Accession

Q00651

Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2)]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Purity: 95.00%

Select Batch:

Data Sheet (262 KB) SDS (251 KB)

COA (232 KB)

Inhibitory Antibodies User Guide (602 KB)

References

[1]. Soilu-Hänninen M, et al. Therapy with antibody against leukocyte integrin VLA-4 (CD49d) is effective and safe in virus-facilitated experimental allergic encephalomyelitis. J Neuroimmunol. 1997 Jan;72(1):95-105. [Content Brief]

[2]. Sasaki K, et al. Preferential expression of very late antigen-4 on type 1 CTL cells plays a critical role in trafficking into central nervous system tumors. Cancer Res. 2007 Jul 1;67(13):6451-8. [Content Brief]

[3]. Szenes E, et al. TCL1 transgenic mice as a model for CD49d-high chronic lymphocytic leukemia. Leukemia. 2020 Sep;34(9):2498-2502. [Content Brief]

Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2) Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse/Human VLA-4/CD49d Antibody (PS/2)IntegrinVLA-4/CD49dα4β1EAEM05leukemiamelanomaTc1Inhibitorinhibitorinhibit

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