Itga4 - integrin alpha 4 Gene

Mus musculus

Also known as CD49D; Itga4B

Gene ID: 16401 | Gene type: protein coding

About Itga4

Summary

Enables fibronectin binding activity. Acts upstream of or within several processes, including chorio-allantoic fusion; face development; and heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Located in cell-cell junction and external side of plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; embryo mesenchyme; genitourinary system; and nervous system. Human ortholog(s) of this gene implicated in autism spectrum disorder and pancreatic Cancer. Orthologous to human ITGA4 (Integrin subunit alpha 4). [provided by Alliance of Genome Resources, Apr 2022]

Itga4 Products(1)

mRNA	Protein	Name
NM_010576.4	NP_034706.3	integrin alpha-4 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables fibronectin binding	IMP IMP: Inferred from mutant phenotype	8145052	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within T cell migration	IMP IMP: Inferred from mutant phenotype	23661644	MGI
acts upstream of or within blood vessel remodeling	IMP IMP: Inferred from mutant phenotype	16529735	MGI
acts upstream of or within cell adhesion	IMP IMP: Inferred from mutant phenotype	12021259	MGI
acts upstream of or within cell migration	IMP IMP: Inferred from mutant phenotype	12021259	MGI
acts upstream of or within chorio-allantoic fusion	IMP IMP: Inferred from mutant phenotype	7539359	MGI
acts upstream of or within face development	IMP IMP: Inferred from mutant phenotype	7539359	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	7539359	MGI
acts upstream of or within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IMP IMP: Inferred from mutant phenotype	8145052	MGI
acts upstream of or within leukocyte cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	8562500	MGI
acts upstream of or within pericyte cell migration	IMP IMP: Inferred from mutant phenotype	16529735	MGI
acts upstream of or within vascular associated smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	16529735	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell-cell junction	IDA IDA: Inferred from direct assay	23610556	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	7539359	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

integrin alpha-4

CD49 antigen-like family member D	LPAM subunit alpha
VLA-4 receptor, alpha 4 subunit	VLA-4 subunit alpha
integrin alpha-IV	integrin alpha4B
lymphocyte Peyer patch adhesion molecules subunit alpha

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99184	Abrilumab		98.35%	Phase 2

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06951	ITGA4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17832	Itga4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24300	Itga4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Itga4	NCBI	NCBI:3676
Macaca fascicularis	Itga4	NCBI	NCBI:102128433

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