CD20/MS4A1 Protein, Dog (HEK293, His, Nanodisc)

CD20/MS4A1 protein-VLP, Dog, a B lymphocyte membrane protein critical for calcium influx and essential for B lymphocyte development, differentiation, and activation. As a component of store-operated calcium (SOC) channels, it promotes calcium influx upon B cell receptor/BCR activation. CD20/MS4A1 Protein, Dog (HEK293, His, Nanodisc) is the recombinant dog-derived CD20/MS4A1 protein, expressed by HEK293, with C-His labeled tag.

The CD20/MS4A1 Protein-VLP, Dog, serves as a B-lymphocyte-specific membrane protein, pivotal in regulating cellular calcium influx essential for the development, differentiation, and activation of B-lymphocytes. Operating as a store-operated calcium (SOC) channel component, it facilitates calcium influx upon activation by the B-cell receptor/BCR. The protein forms homotetramers, contributing to its structural organization and functional role in calcium signaling. An integral part of the B-cell receptor complex, CD20/MS4A1 Protein-VLP, Dog, interacts specifically with the heavy and light chains of cell surface IgM, representing the antigen-binding components of the BCR. This interaction highlights its crucial role in B-cell activation and underscores its significance in the orchestration of immune responses.

Dog

HEK293

C-His

Q3C2E2 (M1-P297)

485430

Full Length

Approximately 25 kDa & 40 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.

Greater than 80% as determined by reducing SDS-PAGE.

Solution.

Supplied as 0.2 μm filtered solution of 20 mM HEPES, 150 mM NaCl, pH7.5 with trehalose as protectant.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.