2. NF-κB Immunology/Inflammation Stem Cell/Wnt
  3. Toll-like Receptor (TLR) RANKL/RANK Wnt β-catenin
  4. Pamidronic acid (Standard)

Pamidronic acid (Standard) is the analytical standard of Pamidronic acid. This product is intended for research and analytical applications. Pamidronic acid, the second-generation nitrogen-containing bisphosphonate, is an inhibitor of bone loss. Pamidronic acid significantly inhibits subchondral bone loss in early osteoarthritis by upregulating the expression of OPG in cartilage and subchondral bone, and inhibiting the expression of RANKL and MMP-9 in both tissues, as well as TLR-4 in cartilage, thereby alleviating cartilage degeneration. Additionally, Pamidronic acid can inhibit the signaling of Wnt and β-catenin, and is applicable for research on osteoporosis and osteosarcoma.

For research use only. We do not sell to patients.

Pamidronic acid (Standard) Chemical Structure

Pamidronic acid (Standard) Chemical Structure

CAS No. : 40391-99-9

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Description
Molecular Weight

235.07

Formula

C3H11NO7P2
CAS No.
SMILES

OC(P(O)(O)=O)(P(O)(O)=O)CCN
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Pamidronic acid (Standard) Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pamidronic acid (Standard)40391-99-9Toll-like Receptor (TLR)RANKL/RANKWntβ-cateninBeta cateninosteoarthritis (OA)osteosarcomaosteoporosisInhibitorinhibitorinhibit

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