2. GPCR/G Protein Neuronal Signaling Membrane Transporter/Ion Channel
  3. 5-HT Receptor Monoamine Transporter Dopamine Receptor
  4. 4-Methylamphetamine hydrochloride

4-Methylamphetamine hydrochloride  (Synonyms: 4-MA hydrochloride)

Cat. No.: HY-W417914 Purity: 99.86%
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4-Methylamphetamine hydrochloride is a 5-HT1A receptor agonist that induces hypothermia in rats by binding to the 5-HT1A receptor. Additionally, 4-Methylamphetamine hydrochloride acts on norepinephrine (NE), dopamine (DA), and serotonin (5-HT) transporters to increase the extracellular levels of these neurotransmitters. 4-Methylamphetamine hydrochloride can be used in the study of neurological disorders.

For research use only. We do not sell to patients.

4-Methylamphetamine hydrochloride Chemical Structure

4-Methylamphetamine hydrochloride Chemical Structure

CAS No. : 41632-56-8

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Based on 1 publication(s) in Google Scholar

4-Methylamphetamine hydrochloride Related Antibodies

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Description

4-Methylamphetamine hydrochloride is a 5-HT1A receptor agonist that induces hypothermia in rats by binding to the 5-HT1A receptor. Additionally, 4-Methylamphetamine hydrochloride acts on norepinephrine (NE), dopamine (DA), and serotonin (5-HT) transporters to increase the extracellular levels of these neurotransmitters. 4-Methylamphetamine hydrochloride can be used in the study of neurological disorders[1][2].

IC50 & Target

5-HT1A Receptor

 

Molecular Weight

185.69

Formula

C10H16ClN
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC(CC1=CC=C(C)C=C1)C.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (673.16 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.3853 mL 26.9266 mL 53.8532 mL
5 mM 1.0771 mL 5.3853 mL 10.7706 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.3853 mL 26.9266 mL 53.8532 mL 134.6330 mL
5 mM 1.0771 mL 5.3853 mL 10.7706 mL 26.9266 mL
10 mM 0.5385 mL 2.6927 mL 5.3853 mL 13.4633 mL
15 mM 0.3590 mL 1.7951 mL 3.5902 mL 8.9755 mL
20 mM 0.2693 mL 1.3463 mL 2.6927 mL 6.7316 mL
25 mM 0.2154 mL 1.0771 mL 2.1541 mL 5.3853 mL
30 mM 0.1795 mL 0.8976 mL 1.7951 mL 4.4878 mL
40 mM 0.1346 mL 0.6732 mL 1.3463 mL 3.3658 mL
50 mM 0.1077 mL 0.5385 mL 1.0771 mL 2.6927 mL
60 mM 0.0898 mL 0.4488 mL 0.8976 mL 2.2439 mL
80 mM 0.0673 mL 0.3366 mL 0.6732 mL 1.6829 mL
100 mM 0.0539 mL 0.2693 mL 0.5385 mL 1.3463 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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4-Methylamphetamine hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4-Methylamphetamine41632-56-84-MA5-HT ReceptorMonoamine TransporterDopamine ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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