2. Others Neuronal Signaling
  3. Fluorescent Dye Amyloid-β
  4. NIAD-4

NIAD-4 is a fluorophore for optical imaging of amyloid-β (Aβ) in the central nervous system (CNS) for Alzheimer’s disease (AD). NIAD-4 binds to the same Aβ site with the binding affinity (Ki) of 10 nM.

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NIAD-4

NIAD-4 Chemical Structure

CAS No. : 868592-56-7

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Based on 1 publication(s) in Google Scholar

NIAD-4 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE NIAD-4

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Description

NIAD-4 is a fluorophore for optical imaging of amyloid-β (Aβ) in the central nervous system (CNS) for Alzheimer’s disease (AD). NIAD-4 binds to the same Aβ site with the binding affinity (Ki) of 10 nM[1].

In Vitro

NIAD-4 binds to amyloid aggregates, hinders its internal rotation, increases its fluorescence quantum yield and fluorescence intensity, thereby making it an effective tool for detecting amyloid. NIAD-4 can cross the blood-brain barrier, and used for amyloid fibrils imaging in brains due to its charge neutrality and low molecular weight. NIAD-4 exhibits an excitation wavelength of 475 nM and an emission wavelength of 610 nM[2][3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NIAD-4 Related Antibodies
Molecular Weight

334.43

Formula

C18H10N2OS2
CAS No.
Appearance

Solid

Color

Orange to reddish brown

Emission (Em)

625
Excitation (Ex)

475
SMILES

N#C/C(C#N)=C/C1=CC=C(C2=CC=C(C3=CC=C(O)C=C3)S2)S1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (74.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9902 mL 14.9508 mL 29.9016 mL
5 mM 0.5980 mL 2.9902 mL 5.9803 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.11%

SDS (393 KB)

COA (246 KB) HNMR (112 KB) LCMS (100 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9902 mL 14.9508 mL 29.9016 mL 74.7541 mL
5 mM 0.5980 mL 2.9902 mL 5.9803 mL 14.9508 mL
10 mM 0.2990 mL 1.4951 mL 2.9902 mL 7.4754 mL
15 mM 0.1993 mL 0.9967 mL 1.9934 mL 4.9836 mL
20 mM 0.1495 mL 0.7475 mL 1.4951 mL 3.7377 mL
25 mM 0.1196 mL 0.5980 mL 1.1961 mL 2.9902 mL
30 mM 0.0997 mL 0.4984 mL 0.9967 mL 2.4918 mL
40 mM 0.0748 mL 0.3738 mL 0.7475 mL 1.8689 mL
50 mM 0.0598 mL 0.2990 mL 0.5980 mL 1.4951 mL
60 mM 0.0498 mL 0.2492 mL 0.4984 mL 1.2459 mL
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NIAD-4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NIAD-4868592-56-7NIAD4NIAD 4Fluorescent DyeAmyloid-ββ-amyloid peptideAβAbetaamyloid-βcentral nervous systemCNSAlzheimer diseaseInhibitorinhibitorinhibit

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