2. Apoptosis
  3. Apoptosis
  4. JR5-26B

JR5-26B is an orally active apoptosis inducer. JR5-26B induces cell death through copper-mediated apoptosis and necroptosis. JR5-26B exhibits antiproliferative activity on MIA PaCa-2, PANC-1, PAN02, SU.86.86, and KPC-2 cells with IC50s of 0.6, 4.4, 8.0, 1.1, and 3.4μM, respectively.

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JR5-26B Chemical Structure

JR5-26B Chemical Structure

CAS No. : 2446965-04-2

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JR5-26B Related Antibodies

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Description

JR5-26B is an orally active apoptosis inducer. JR5-26B induces cell death through copper-mediated apoptosis and necroptosis. JR5-26B exhibits antiproliferative activity on MIA PaCa-2, PANC-1, PAN02, SU.86.86, and KPC-2 cells with IC50s of 0.6, 4.4, 8.0, 1.1, and 3.4μM, respectively[1].

Molecular Weight

364.38

Formula

C19H17FN6O
CAS No.
SMILES

O=C(NC1=C2N=CC=CC2=CC(F)=C1)C3=NC=C(N=C3)N4C[C@@]5([C@H]([C@@]5(C4)[H])N)[H]
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Room temperature in continental US; may vary elsewhere.
Storage

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Purity & Documentation
References
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JR5-26B Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JR5-26B2446965-04-2ApoptosisPancreatic CancerapoptosisMIA PaCa-2PANC-1BxPC-3PAN02SU.86.86KPC-2Inhibitorinhibitorinhibit

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