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and R5/W677

" in MedChemExpress (MCE) Product Catalog:

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(2) Zinc Finger Protein (1) β-catenin (8) γ-Glutamyl Transferase (GGT) (1)
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Click Chemistry:	DBCO (1) Azide (15) Alkynes (6)
Oligonucleotides:	Guanosine (3) Nucleotide Analogs (20) mRNA (1) Phospholipids (1) Cap Analogs (7) Guanine (3) siRNAs (9) pH Modifiers (6) Antioxidants (1) Pegylated Lipids (2) Liposomal Film-forming Agents (1) Nucleoside Analogs (18) Disintegrants (4) Mouse Pre-designed siRNA Sets (1) Cationic Lipids (1) Cytosine (1) Human Pre-designed siRNA Sets (7) Polymers (1) Solvents (5) Adenosine (6) Preservatives (4) Thickeners (5) Nucleoside Phosphoramidites (9) Inosine Nucleoside (2) Fillers (3) Thymine (1) Rat Pre-designed siRNA Sets (1) Suspending Agents (4) Adenine (2) Solubilizing Agents (9) Surfactants (9) Binders (2) Bases (8) Cytidine (4) Cholesterol (1) Cytidine Nucleotide (2) Adenine Nucleotide (2) Guanine Nucleotide (1) Aptamers (1) Uridine (2) Inosine (1) Emulsifiers (21) Uracil (1) Chelating Agents (2)

2683

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

201

Biochemical Assay Reagents

1576

Peptides

Inhibitory Antibodies

199

Natural
Products

320

Recombinant Proteins

Isotope-Labeled Compounds

194

Antibodies

Click Chemistry

137

Oligonucleotides

Targets Recommended: Fat Mass and Obesity-associated Protein (FTO)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P10510A

R5 peptide acetate	Biochemical Assay Reagents	Others
R5 peptide acetate shows silica-precipitating activity .

HY-103156

NAS-181 dimesylate 3 Publications Verification	5-HT Receptor	Neurological Disease
NAS181 is a potent and selective antagonist of rat 5-HT_1B receptor, with a K_i of 47 nM. NAS181 shows 13-fold selectivity for r5-HT_1B over bovine 5-HT_1B receptor (K_i=630 nM). NAS181 increases the 5-HT turnover and the synaptic concentration of 5-HT by inhibiting terminal r5-HT_1B autoreceptors .

HY-13406

TAK-779 5+ Cited Publications Takeda 779	CCR HIV CXCR	Infection Inflammation/Immunology Endocrinology
TAK-779 is a potent and selective nonpeptide antagonist of *CCR5* and CXCR3, with a K_i of 1.1 nM for CCR5, and effectively and selectively inhibits R5 HIV-1, with EC₅₀ and EC₉₀ of 1.2 nM and 5.7 nM, respectively, in MAGI-CCR5 cells.

HY-15971A

AMD 3465 5 Publications Verification GENZ-644494	CXCR HIV	Infection Endocrinology
AMD 3465 (GENZ-644494) is a potent antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12 ^AF647 to CXCR4, with IC₅₀s of 0.75 nM and 18 nM in SupT1 cells; AMD 3465 also potently inhibits the replication of X4 HIV strains (IC₅₀: 1-10 nM), but has no effect on CCR5-using (R5) viruses.

HY-15971

AMD 3465 hexahydrobromide 5 Publications Verification GENZ-644494 hexahydrobromide	CXCR HIV	Infection Endocrinology
AMD 3465 hexahydrobromide (GENZ-644494 hexahydrobromide) is a potent antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12 ^AF647 to CXCR4, with IC₅₀s of 0.75 nM and 18 nM in SupT1 cells; AMD 3465 also potently inhibits the replication of X4 HIV strains (IC₅₀: 1-10 nM), but has no effect on CCR5-using (R5) viruses.

HY-P10510

R5 peptide	Biochemical Assay Reagents	Others
R5 peptide shows silica-precipitating activity and can be isolated from Cylindrotheca fusiformis .

HY-129331

Neothramycin A	Antibiotic Bacterial Fungal	Infection Cancer
Neothramycin A is an antibiotic, which can be isolated from Streptomyces. Neothramycin A exhibits board spectrum antimicrobial activity, inhibits Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli W677, and Saccharomyces cerevisia with MIC of 25-50 μg/mL. Neothramycin A exhibits antitumor efficacy against leukemia in mouse models .

HY-135507A

NAS-181 free base	5-HT Receptor	Neurological Disease
NAS181 free base is a potent and selective antagonist of rat 5-HT_1B receptor, with a K_i of 47 nM. NAS181 free base shows 13-fold selectivity for r5-HT_1B over bovine 5-HT_1B receptor (K_i=630 nM). NAS181 free base increases the 5-HT turnover and the synaptic concentration of 5-HT by inhibiting terminal r5-HT_1B autoreceptors .

HY-135507

NAS-181	5-HT Receptor	Neurological Disease
NAS-181 is a potent and selective rat 5-hydroxytryptamine1B (r5-HT1B) antagonist with an K_i value of 47 nM. NAS-181 increases the 5-HTP accumulation in rat brain regions .

HY-107401

Ancriviroc SCH-351125	HIV CCR	Infection
Ancriviroc (SCH-351125) is an orally active *CCR5* antagonist. Ancriviroc has a broad-spectrum antiviral activity against HIV-1 isolates using CCR5 as their entry coreceptor (such as ASM 80, 92US715 and YU-2) with IC₅₀s of 0.4-9 nM. Ancriviroc strongly inhibits the replication of R5-using HIV-1 isolates in SCID-hu Thy/Liv mice model of HIV-1 infection. Ancriviroc can be used for HIV infection research .

HY-12108

S 1360	HIV Integrase HIV	Infection
S 1360 is a potent and selective inhibitor of HIV-1 integrase. S 1360 inhibits the catalytic activity of purified integrase ( IC₅₀: 20 nM). The EC₅₀, and CC₅₀ of S 1360 in MTT assay (MT-4 cells infected with HIV-1 IIIB) are 200 nM and 12 μM, respectively. S 1360 has antiviral activity against both X4 tropic and R5 tropic strains, as well as NRTI, NNRTI and PI drug-resistant variants .

HY-15971AR

AMD 3465 (Standard)	CXCR HIV	Infection Endocrinology
AMD 3465 (Standard) is the analytical standard of AMD 3465. This product is intended for research and analytical applications. AMD 3465 (GENZ-644494) is a potent antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12AF647 to CXCR4, with IC50s of 0.75 nM and 18 nM in SupT1 cells; AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM), but has no effect on CCR5-using (R5) viruses.

HY-174751

Human CCL5 mRNA	mRNA	Inflammation/Immunology
Human CCL5 mRNA encodes the human C-C motif chemokine ligand 5 (CCL5) protein, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. CCL5 is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor.

HY-15971R

AMD 3465 hexahydrobromide (Standard)	CXCR HIV	Infection Endocrinology
AMD 3465 (hexahydrobromide) (Standard) is the analytical standard of AMD 3465 (hexahydrobromide). This product is intended for research and analytical applications. AMD 3465 hexahydrobromide (GENZ-644494 hexahydrobromide) is a potent antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12AF647 to CXCR4, with IC50s of 0.75 nM and 18 nM in SupT1 cells; AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM), but has no effect on CCR5-using (R5) viruses.

HY-103693

NAZ2329 3 Publications Verification	Phosphatase	Cancer
NAZ2329, the first cell-permeable inhibitor of R5 subfamily of receptor-type protein tyrosine phosphatases (RPTPs), allosterically and preferentially inhibits PTPRZ (IC₅₀=7.5 µM for hPTPRZ1) and PTPRG (IC₅₀=4.8 µM for hPTPRG) over other PTPs. NAZ2329 binds to the active D1 domain and more potently inhibits PTPRZ-D1 fragment (IC₅₀ of 1.1 µM) than the whole intracellular (D1 + D2) fragment (IC₅₀ of 7.5 µM). NAZ2329 can effectively inhibit tumor growth of the glioblastoma cells and suppress stem cell-like properties .

HY-134851

HIV-1 inhibitor-6 1 Publications Verification	HIV	Infection
HIV-1 inhibitor-6 (compound 9), a diheteroarylamide-based compound, is a potent HIV-1 pre-mRNA alternative splicing inhibitor. HIV-1 inhibitor-6 blocks HIV replication. HIV-1 inhibitor-6 is active against wild-type HIV-1IIIB (subtype B, X4-tropic) and HIV-1 97USSN54 (subtype A, R5-tropic) with EC₅₀s of 0.6 μM and 0.9 μM, respectively. HIV-1 inhibitor-6 inhibits HIV strains resistant to agents targeting HIV reverse transcriptase, protease, integrase, and coreceptor CCR5 with EC₅₀s ranging from 0.9 to 1.5 μM .

HY-136805

Kv1.5-IN-1	Potassium Channel	Neurological Disease
Kv1.5-IN-1 is a Kv1.5 channel inhibitor. Its target selectivity and pharmacodynamic effects were evaluated in an in vitro rat model. After the introduction of a methoxy group at the R5 position, Kv1.5-IN-1 showed inhibitory potency similar to that of the unsubstituted compound. Its IC50 value for hKv1.5 channels was 0.51 μM. Kv1.5-IN-1 exhibited a high degree of selectivity, nearly 2,600 times higher than compound Ik and 300 times higher than compound IId, indicating that it may be a safe inhibitor. Due to its good pharmacological behavior, Kv1.5-IN-1 deserves further pharmacodynamic and pharmacokinetic evaluation. These properties make Kv1.5-IN-1 a potential Kv1.5 channel inhibitor that may have application prospects in the treatment of related diseases.

HY-100754B

(2R,5S)-Ritlecitinib (2R,5S)-PF-06651600	JAK	Inflammation/Immunology
(2R,5S)-Ritlecitinib (2R,5S)-PF-06651600) is a JAK3 inhibitor (IC50=144.8 nM) .

HY-14664F

(3R,5S)-Fluvastatin sodium (3R,5S)-XU 62-320	HMG-CoA Reductase (HMGCR) Autophagy	Cancer
(3R,5S)-Fluvastatin ((3R,5S)-XU 62-320) sodium is the 3R,5S-isomer Fluvastatin. Fluvastatin (XU 62-320 free acid) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway .

HY-W002304R

*(R)-5-Oxopyrrolidine-2-carboxylic acid (Standard)*	Reference Standards Drug Derivative	Metabolic Disease
(R)-5-Oxopyrrolidine-2-carboxylic acid (Standard) is the analytical standard of (R)-5-Oxopyrrolidine-2-carboxylic acid (HY-W002304). This product is intended for research and analytical applications. (R)-5-Oxopyrrolidine-2-carboxylic acid (D-Pyroglutamic acid) is a cyclic derivative of D-glutamate. (R)-5-Oxopyrrolidine-2-carboxylic acid can be used in the research of metabolic syndrome and end-stage renal disease .

HY-N0894A

(3R,5R)-Octahydrocurcumin (3R,5R)-Hexahydrobisdemethoxycurcumin	Drug Metabolite	Neurological Disease Inflammation/Immunology
(3R,5R)-Octahydrocurcumin (Compound 7) is gut microbial metabolite of Curcumin (HY-N0005). (3R,5R)-Octahydrocurcumin exhibits neuroprotective efficacy against Aβ25-35-induced cell damage in SH-SY5Y, and anti-inflammatory activity against LPS-stimulated mouse microglial BV-2 .

HY-W002304

*(R)-5-Oxopyrrolidine-2-carboxylic acid*	Drug Derivative	Metabolic Disease
(R)-5-Oxopyrrolidine-2-carboxylic acid (D-Pyroglutamic acid) is a cyclic derivative of D-glutamate. (R)-5-Oxopyrrolidine-2-carboxylic acid can be used in the research of metabolic syndrome and end-stage renal disease .

HY-Z5058S

(3R,5S)-Fluvastatin-d7 sodium (3R,5S)-XU 62-320-d₇	Isotope-Labeled Compounds	Others
(3R,5S)-Fluvastatin-d₇ (sodium) is the deuterium labeled (3R,5S)-Fluvastatin sodium .

HY-10002B

(1R,5Z)-Calcitriol (1R,5Z)-1,25-Dihydroxyvitamin D3	VD/VDR	Cancer
(1R,5Z)-Calcitriol ((1R,5Z)-1,25-Dihydroxyvitamin D3) is a Calcitriol (HY-10002) isomer. Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist .

HY-109022A

(3R,5R,6S)-Atogepant (3R,5R,6S)-MK-8031; (3R,5R,6S)-AGN-241689	CGRP Receptor	Neurological Disease
(3R,5R,6S)-Atogepant ((3R,5R,6S)-MK-8031) is the enantiomer of Atogepant (HY-109022). Atogepant is a calcitonin gene-related peptide receptor (CGRP) antagonist. Atogepant can be used for researching migraine.

HY-W699829

(3R,5R)-Rosuvastatin Lactone-d6	Isotope-Labeled Compounds Drug Isomer	Cardiovascular Disease
(3R,5R)-Rosuvastatin Lactone-d₆ is the deuterium labeled (3R,5R)-Rosuvastatin Lactone (HY-135406). (3R,5R)-Rosuvastatin Lactone is an isomer of Rosuvastatin Lactone.

HY-14664B

(3R,5S)-Fluvastatin (3R,5S)-XU 62-320 free acid	HMG-CoA Reductase (HMGCR) Autophagy	Cardiovascular Disease Cancer
(3R,5S)-Fluvastatin is the 3R,5S-isomer Fluvastatin. Fluvastatin (XU 62-320 free acid) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC₅₀ of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway .

HY-135406

(3R,5R)-Rosuvastatin Lactone	Drug Isomer	Cardiovascular Disease Metabolic Disease
(3R,5R)-Rosuvastatin Lactone is an isomer of Rosuvastatin Lactone.

HY-17504C

(3R,5R)-Rosuvastatin	HMG-CoA Reductase (HMGCR) Potassium Channel Autophagy	Cardiovascular Disease Metabolic Disease
(3R,5R)-Rosuvastatin is the (3R,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor with an IC₅₀ of 11 nM . Rosuvastatin potently blocks human ether-a-go-go related gene (hERG) current with an IC₅₀ of 195 nM . Rosuvastatin reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin is very effective in lowering low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels .

HY-N5054

*(R)-5,7-Dimethoxyflavanone*	TNF Receptor	Inflammation/Immunology
(R)-5,7-Dimethoxyflavanone shows potent antimutagenic activity against MeIQ mutagenesis in Ames test using the S. typhimurium TA100 and TA98 strains . And (R)-5,7-Dimethoxyflavanone significantly and dose-dependently inhibits the inflammatory mediato .

HY-N10405

*(R)-5-Hydroxy-1,7-diphenyl-3-heptanone*	Keap1-Nrf2	Metabolic Disease
(R)-5-Hydroxy-1,7-diphenyl-3-heptanone is a diarylheptanoid that can be found in Alpinia officinarum. (R)-5-Hydroxy-1,7-diphenyl-3-heptanone ameliorates oxidative stress and insulin resistance via activation of Nrf2/ARE pathway .

HY-W061439

(3R,5S)-5-O-DMT-3-pyrrolidinol	Nucleoside Antimetabolite/Analog	Others
(3R,5S)-5-O-DMT-3-pyrrolidinol is a compound with a dimethoxytrityl (DMT) protecting group and a 3-pyrrolidinol structure. (3R,5S)-5-O-DMT-3-pyrrolidinol can be used in the synthesis of nucleic acids.

HY-141723S

(4R,5R)-5-(2,4-Difluorophenyl)-4-methyl-5-(1H-1,2,4-triazol-1-ylmethyl)-2-oxazolidinone-d3	Isotope-Labeled Compounds	Others
(4R,5R)-5-(2,4-Difluorophenyl)-4-methyl-5-(1H-1,2,4-triazol-1-ylmethyl)-2-oxazolidinone-d₃ is the deuterium labeled (4R,5R)-5-(2,4-Difluorophenyl)-4-methyl-5-(1H-1,2,4-triazol-1-ylmethyl)-2-oxazolidinone .

HY-W048541AR

*(R)-5,7-Difluorochroman-4-ol (Standard)*	Reference Standards
(R)-5,7-Difluorochroman-4-ol (Standard) is the analytical standard of (R)-5,7-Difluorochroman-4-ol. This product is intended for research and analytical applications.

HY-21687R

*(R)-5-(2-Aminopropyl)-2-methoxybenzenesulfonamide (Standard)*	Reference Standards
(R)-5-(2-Aminopropyl)-2-methoxybenzenesulfonamide (Standard) is the analytical standard of (R)-5-(2-Aminopropyl)-2-methoxybenzenesulfonamide. This product is intended for research and analytical applications.

HY-162083

CB2R/5-HT1AR agonist 1	Cannabinoid Receptor 5-HT Receptor	Neurological Disease
CB2R/5-HT1AR agonist 1 (Compound 2o) is an orally active partial agonist of the CB₂ receptor (EC₅₀=479.6 nM). CB2R/5-HT1AR agonist 1 is a full agonist of *5-HT_1A* receptor (EC₅₀=2.7 μM). CB2R/5-HT1AR agonist 1 exhibits anti-anxiety and anti-depressive effects. CB2R/5-HT1AR agonist 1 possesses favorable pharmacokinetic properties .

HY-135374

(3R,5S)-Atorvastatin sodium	Drug Metabolite	Metabolic Disease Inflammation/Immunology
(3R,5S)-Atorvastatin sodium is an impurity of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin inhibits human SV-SMC proliferation and invasion with IC₅₀s of 0.39 μM and 2.39 μM, respectively .

HY-107101

(5R)-5-Hydroxytriptolide PG 701; LLDT-8; 5α-Hydroxytriptolide	Others	Inflammation/Immunology
(5R)-5-Hydroxytriptolide is an extracted compound from Tripterygium, and shows lower cell cytotoxicity and higher immunosuppressive activity. (5R)-5-Hydroxytriptolide can be used for study of rheumatoid arthritis .

HY-113025A

L-hydroxylysine dihydrochloride (2S,5R)-5-Hydroxylysine dihydrochloride	Endogenous Metabolite	Others
L-hydroxylysine dihydrochloride ((2S,5R)-5-Hydroxylysine dihydrochloride), an amino acid, is exclusive to collagen protein, which is formed by posttranslational hydroxylation of some lysine residues .

HY-19322C

(1S,3R,5R)-PIM447 dihydrochloride (1S,3R,5R)-LGH447 dihydrochloride	Pim	Cancer
(1S,3R,5R)-PIM447 (dihydrochloride) an PIM inhibitor extracted from patent US 20100056576 A1, compound example 72, has IC₅₀ values of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3.

HY-W1119946

(3R,5S)-5-O-DMT-3-pyrrolidinol-benzyl laurate	Nucleoside Antimetabolite/Analog	Others
(3R,5S)-5-O-DMT-3-pyrrolidinol-benzyl laurate is a laurate derivative with a dimethoxytrityl (DMT) protecting group and a 3-pyrrolidinol structure. (3R,5S)-5-O-DMT-3-pyrrolidinol-benzyl laurate can be used for oligonucleotide modification or as a lipid-soluble delivery vehicle.

HY-W1119952

(3R,5S)-5-O-DMT-3-pyrrolidinol-12-oxododecanoic acid	Biochemical Assay Reagents	Others
(3R,5S)-5-O-DMT-3-pyrrolidinol-12-oxododecanoic acid is a biochemical assay reagent that can be used to synthesize a variety of compounds. (3R,5S)-5-O-DMT-3-pyrrolidinol-12-oxododecanoic acid is the intermediate for the synthesis of complex compounds and building blocks.

HY-W048541A

*(R)-5,7-Difluorochroman-4-ol*	Drug Intermediate	Others
(R)-5,7-Difluorochroman-4-ol is a drug intermediate for synthesis of various active compounds.

HY-N13540

*(R)-5-Hydroxy-7-(4-hydroxyphenyl)-1-phenylheptan-3-one*	Others	Others
(R)-5-Hydroxy-7-(4-hydroxyphenyl)-1-phenylheptan-3-one is a phenol product that can be isolated from Alpinia officinarum .

HY-P9974

Vantictumab 1 Publications Verification OMP-18R5	Wnt	Cancer
Vantictumab (OMP-18R5) is a fully human IgG2 monoclonal antibody. Vantictumab inhibits Wnt pathway signaling by binding to *FZD1/2/5/7/8* receptors. Vantictumab can be studied against cancers through direct actions on tumor cells, including CSCs, and effects on the stroma, such as metastatic HER2-negative breast cancer and metastatic pancreatic adenocarcinoma .

HY-20004R

*(R)-5-bromo-3-[(1-methyl-2-pyrrolidinyl)methyl]-1H-indole (Standard)*	Reference Standards
(R)-5-bromo-3-[(1-methyl-2-pyrrolidinyl)methyl]-1H-indole (Standard) is the analytical standard of (R)-5-bromo-3-[(1-methyl-2-pyrrolidinyl)methyl]-1H-indole. This product is intended for research and analytical applications.

HY-RS10540

PIK3R5 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PIK3R5 Human Pre-designed siRNA Set A contains three designed siRNAs for PIK3R5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PIK3R5 Human Pre-designed siRNA Set A PIK3R5 Human Pre-designed siRNA Set A

HY-RS14219

TAS2R5 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TAS2R5 Human Pre-designed siRNA Set A contains three designed siRNAs for TAS2R5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TAS2R5 Human Pre-designed siRNA Set A TAS2R5 Human Pre-designed siRNA Set A

HY-160251

3-HC-Gluc (3'R,5k'S)-trans-3'-Hydroxycotinine glucuronide	Drug Metabolite	Others
3-HC-Gluc ((3’R,5k’s)-trans-3’ -Hydroxycotinine glucuronide) The trans-structure of 3-HC, the main metabolite of nicotine .

HY-RS11018

PPP2R5A Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PPP2R5A Human Pre-designed siRNA Set A contains three designed siRNAs for PPP2R5A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PPP2R5A Human Pre-designed siRNA Set A PPP2R5A Human Pre-designed siRNA Set A

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W002304

*(R)-5-Oxopyrrolidine-2-carboxylic acid*	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Drug Derivative
(R)-5-Oxopyrrolidine-2-carboxylic acid (D-Pyroglutamic acid) is a cyclic derivative of D-glutamate. (R)-5-Oxopyrrolidine-2-carboxylic acid can be used in the research of metabolic syndrome and end-stage renal disease .

HY-N5054

*(R)-5,7-Dimethoxyflavanone*	Flavonoids other families Classification of Application Fields Flavonones Source classification Plants Inflammation/Immunology Disease Research Fields	TNF Receptor
(R)-5,7-Dimethoxyflavanone shows potent antimutagenic activity against MeIQ mutagenesis in Ames test using the S. typhimurium TA100 and TA98 strains . And (R)-5,7-Dimethoxyflavanone significantly and dose-dependently inhibits the inflammatory mediato .

HY-N10405

*(R)-5-Hydroxy-1,7-diphenyl-3-heptanone*	Natural Products Classification of Application Fields Source classification Metabolic Disease Alpinia officinarum Hance Plants Disease Research Fields Zingiberaceae	Keap1-Nrf2
(R)-5-Hydroxy-1,7-diphenyl-3-heptanone is a diarylheptanoid that can be found in Alpinia officinarum. (R)-5-Hydroxy-1,7-diphenyl-3-heptanone ameliorates oxidative stress and insulin resistance via activation of Nrf2/ARE pathway .

HY-129331

Neothramycin A	Microorganisms Antibiotics Source classification	Antibiotic Bacterial Fungal
Neothramycin A is an antibiotic, which can be isolated from Streptomyces. Neothramycin A exhibits board spectrum antimicrobial activity, inhibits Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli W677, and Saccharomyces cerevisia with MIC of 25-50 μg/mL. Neothramycin A exhibits antitumor efficacy against leukemia in mouse models .

HY-W002304R

*(R)-5-Oxopyrrolidine-2-carboxylic acid (Standard)*	Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Reference Standards Drug Derivative
(R)-5-Oxopyrrolidine-2-carboxylic acid (Standard) is the analytical standard of (R)-5-Oxopyrrolidine-2-carboxylic acid (HY-W002304). This product is intended for research and analytical applications. (R)-5-Oxopyrrolidine-2-carboxylic acid (D-Pyroglutamic acid) is a cyclic derivative of D-glutamate. (R)-5-Oxopyrrolidine-2-carboxylic acid can be used in the research of metabolic syndrome and end-stage renal disease .

HY-N0894A

(3R,5R)-Octahydrocurcumin (3R,5R)-Hexahydrobisdemethoxycurcumin	Source classification Phenols Polyphenols Plants Tacca chantrieri Andre Taccaceae	Drug Metabolite
(3R,5R)-Octahydrocurcumin (Compound 7) is gut microbial metabolite of Curcumin (HY-N0005). (3R,5R)-Octahydrocurcumin exhibits neuroprotective efficacy against Aβ25-35-induced cell damage in SH-SY5Y, and anti-inflammatory activity against LPS-stimulated mouse microglial BV-2 .

HY-113025A

L-hydroxylysine dihydrochloride (2S,5R)-5-Hydroxylysine dihydrochloride	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
L-hydroxylysine dihydrochloride ((2S,5R)-5-Hydroxylysine dihydrochloride), an amino acid, is exclusive to collagen protein, which is formed by posttranslational hydroxylation of some lysine residues .

HY-N13540

*(R)-5-Hydroxy-7-(4-hydroxyphenyl)-1-phenylheptan-3-one*	Source classification Phenols Alpinia officinarum Hance Plants Zingiberaceae	Others
(R)-5-Hydroxy-7-(4-hydroxyphenyl)-1-phenylheptan-3-one is a phenol product that can be isolated from Alpinia officinarum .

HY-W040240R

(3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one (Standard)	Source classification Endogenous metabolite Saccharides	Reference Standards Endogenous Metabolite
(3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one (Standard) is the analytical standard of (3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one. This product is intended for research and analytical applications. (3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one is an endogenous metabolite.

HY-N13414

(3R,5S,E)-1,7-Diphenylhept-1-ene-3,5-diol	Source classification Phenols Polyphenols Plants Curcuma longa Zingiberaceae	Others
(3R,5S,E)-1,7-Diphenylhept-1-ene-3,5-diol is a natural product .

HY-W040240

(3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one	Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Saccharides	Endogenous Metabolite
(3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one is an endogenous metabolite generated by the thermal decomposition of β-D-glucopyranose and further isomerization .

HY-N15206

(3R,5R)-1-(4-Hydroxy-3-methoxyphenyl)-7-phenylheptane-3,5-diol	Monophenols Source classification Phenols Alpinia officinarum Hance Plants Zingiberaceae	Endogenous Metabolite
(3R,5R)-1-(4-Hydroxy-3-methoxyphenyl)-7-phenylheptane-3,5-diol (compound 20) is a plant metabolite that can be isolated from Zingiberaceae plants .

HY-N15207

(3R,5R)-1-(4-Hydroxyphenyl)-7-phenyl-3,5-heptanediol	Monophenols Source classification Phenols Alpinia officinarum Hance Plants Zingiberaceae	Others
(3R,5R)-1-(4-Hydroxyphenyl)-7-phenyl-3,5-heptanediol is an antiemetic found in Alpinia officinarum that significantly inhibits copper sulfate-induced emesis in young chicks (with an inhibition rate of 50.9% at a dose of 20 mg/kg and 37.7% at a dose of 50 mg/kg) .

HY-N13555

(19R)-5β,19-Epoxy-19-methoxycucurbita-6,23-diene-3β,25-diol	Triterpenes Terpenoids Source classification Cucurbitaceae Plants Momordica charantia Linn.	Others
(19R)-5β,19-Epoxy-19-methoxycucurbita-6,23-diene-3β,25-diol is a triterpenoid product that can be isolated from Momordica charantia .

HY-N13541

(19S,23R)-5β,19-Epoxy-19,23-dimethoxycucurbita-6,24-dien-3β-ol	Natural Products Source classification Cucurbitaceae Plants Momordica charantia Linn.	Others
(19S,23R)-5β,19-Epoxy-19,23-dimethoxycucurbita-6,24-dien-3β-ol is a natural product .

HY-N9093

(3R,5R)-3,5-Diacetoxy-1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)heptane	Source classification Phenols Curcuma kwangsiensis S. K. Lee & C. F. Liang Plants Zingiberaceae	Others
(3R,5R)-3,5-Diacetoxy-1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)heptane, a diarylheptanoid from the rhizomes of Curcuma kwangsiensis, possesses a variety of biological and pharmacological activities including antioxidant, antihepa totoxic, anti-inflammatory, antiproliferative, antiemetic, and antitumor activities .

HY-121401A

(−)-Myrtenal (1R)-(−)-Myrtenal; (−)-(1R,5S)-Myrtenal	Other Monoterpenes Classification of Application Fields Terpenoids Labiatae Source classification Erythrina poeppigiana Metabolic Disease Plants Disease Research Fields	Akt
(-)-Myrtenal ((1R)-(-)-Myrtenal) is an orally active terpene with antitumour activity. (-)-Myrtenal ameliorates hyperglycemia by enhancing GLUT2 through Akt in the skeletal muscle and liver of diabetic rats .

HY-N1459R

Campesterol (Standard) (24R)-5-Ergosten-3β-ol (Standard)	Microorganisms other families Classification of Application Fields Source classification Plants Endogenous metabolite Disease Research Fields Steroids Cancer	Reference Standards Endogenous Metabolite
Campesterol (Standard) is the analytical standard of Campesterol. This product is intended for research and analytical applications. Campesterol is a plant sterol with cholesterol lowering and anticarcinogenic effects.

HY-139637

(±)-Silybin Silibinin (mixture of Silybin A and Silybin B)	Flavanonols Flavonoids Source classification Cyamopsis tetragonoloba (L.) Taub. Plants Compositae	Apoptosis
(±)-Silybin is the racemate of Silybin (HY-N0779A). Silybin induces apoptosis and exhibits hepatoprotective, antioxidant, anti-inflammatory, anti-cancer activity .

HY-135252

N-Desbutyroyl acebutolol Deacyl acebutolol; M and B 17127	Alkaloids Classification of Application Fields Other Alkaloids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
N-Desbutyroyl Acebutolol (compound Ⅲ) is a metabolite of Acebutolol (HY-17497) .

HY-109051

Arfolitixorin	Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite
Arfolitixorin is a potent 5-Fluorouracil (5-FU) moderator. Arfolitixorin is an immediately active form of Folate, [6R]-5,10-methylenetetrahydrofolate ([6R]-MTHF). Arfolitixorin is potent for the research of metastatic colorectal cancer .

HY-109051C

Arfolitixorin sulfate	Alkaloids Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
Arfolitixorin sulfate is a potent 5-Fluorouracil (5-FU) moderator. Arfolitixorin sulfate is an immediately active form of Folate, [6R]-5,10-methylenetetrahydrofolate ([6R]-MTHF). Arfolitixorin sulfate is potent for the research of metastatic colorectal cancer .

HY-N14780

Pochonin D (+)-Pochonin D	Natural Products Microorganisms Source classification	HSP Interleukin Related Enterovirus
Pochonin D ((+)-Pochonin D) is an inhibitor of heat shock protein 90 (Hsp90) with antiviral and anti-inflammatory activities. Pochonin D inhibits Hsp90, affecting the homeostasis, folding, and assembly processes of viral proteins, reducing the replication ability of the virus. Pochonin D reduces the infiltration of inflammatory cells and the secretion of inflammatory cytokines such as TNF-α and IL-1β, alleviating the inflammatory response. Pochonin D is promising for research of Human rhinoviruses (HRV) infections and cancers .

HY-N14735

Dotriacolide	Natural Products Microorganisms Source classification	Beta-lactamase
Dotriacolide is a β-actamase inhibitor. Dotriacolide has significant inhibitory activities against both penicillinase and cephalosporinase with ID₅₀ values of 0.61 μg/mL and 0.15 μg/mL, respectively. Dotriacolide is promising for research of infectious diseases .

HY-N15639

Patrinoside	Sambucus ebulus L. Viburnaceae Source classification Plants Saccharides Monosaccharides	Others
Patrinoside is an iridoid glucoside. Patrinoside has choleretic, anti-inflammatory and antispasmodic activities .

HY-N15691

Tadehaginoside	Labiatae Scutellaria salviifolia Benth. Source classification Phenols Polyphenols Plants	Keap1-Nrf2 NF-κB
Tadehaginoside, a phenylpropanoid glycoside, is a regulator of lipogenesis and glucose consumption. Tadehaginoside has antioxygenic property. Tadehaginoside mediates liver protection against oxidative stress injury and inflammation by regulating Nrf2 and NF-κB signaling pathways in hepatocytes. Tadehaginoside can be used for the study of obesity and diabetes .

HY-127029A

Umbelliprenin	Natural Products Source classification Umbelliferae Carpesium faberi C. Winkl. Plants	NO Synthase Lipoxygenase
Umbelliprenin, a prenylated coumarin, is an antioxidant with anticancer, anti-inflammatory and immunomodulatory effects. Umbelliprenin inhibits lipoxygenase managing the inflammation pathways. In inflammatory macrophages, Umbelliprenin suppresses nitric oxide production as well as inducible nitric oxide synthase (NO synthase) .

HY-136648A

2'-Deoxyadenosine-5'-triphosphate trisodium dATP trisodium	Alkaloids Classification of Application Fields Other Alkaloids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite DNA/RNA Synthesis
2'-Deoxyadenosine-5'-triphosphate (dATP) trisodium is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase. 2'-Deoxyadenosine-5'-triphosphate is promising for research of genetic immunodeficiency diseases adenosine deaminase deficiency and purine nucleotide phosphorylase deficiency .

HY-129566

Withanolide B	Neurological Disease Classification of Application Fields Source classification Metabolic Disease Withania somnifera Solanaceae Plants Inflammation/Immunology Disease Research Fields Steroids	ERK Wnt β-catenin RUNX
Withanolide B is an active component of W. somnifera Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2 and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects .

HY-N1871

4-(2-Hydroxy-1-methoxyethyl)-1,2-benzenediol	Oleaceae Source classification Syringa reticulata Polyphenols Plants	Others
4-(2-Hydroxy-1-methoxyethyl)-1,2-benzenediol is a phenylethanoid isolated from the stem bark of Syringa reticulate (Bl.) Hara (Oleaceae) with expectorant and antiasthmatic activity .

HY-N0681

D-Pantothenic acid hemicalcium salt 5+ Cited Publications Calcium pantothenate; Calcium D-pantothenate; Vitamin B5 calcium salt	Natural Products other families Classification of Application Fields Source classification Other Diseases Plants Endogenous metabolite Disease Research Fields	Reactive Oxygen Species (ROS)
D-Pantothenic acid hemicalcium salt is an orally active vitamin that reduces patulin in apple juice. D-Pantothenic acid hemicalcium salt removes ROS. D-Pantothenic acid hemicalcium salt has antibacterial and immunomodulatory activities. D-Pantothenic acid hemicalcium salt also has the effect of improving osteoporosis and obesity ^[5] .

HY-N15533

(S)-Menthiafolic acid	Ketones, Aldehydes, Acids Source classification Piperaceae Piper crocatum Ruiz & Pav. Plants	Drug Metabolite
(S)-Menthiafolic acid is a component found in wines and grape juices. (S)-Menthiafolic acid can be generated from the grape-derived (S)-menthiafolic acid glucose ester during alcoholic and malolactic fermentation, thereby influencing the aroma components of wine .

HY-113110

Cysteinylglycine	Natural Products Human Gut Microbiota Metabolites Microorganisms Source classification Disease markers Endocrine diseases Metabolic Disease Nervous System Disorder Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Cysteinylglycine is a dipeptide produced by the decomposition of extracellular glutathione catalyzed by γ-glutamyl transpeptidase. Cysteinylglycine is a highly reactive metabolite. Cysteinylglycine is currently mainly used in neurodegenerative diseases and breast cancer research .

HY-N13837

2-Methoxy-1,6-dimethyl-5-vinyl-9,10-dihydrophenanthren-7-ol	Natural Products Juncus effusus Linn. Juncaceae Source classification Phenols Plants	Drug Derivative HSV
2-Methoxy-1,6-dimethyl-5-vinyl-9,10-dihydrophenanthren-7-ol (Compound 1) is a 9,10-dihydrophenanthrene derivative. 2-Methoxy-1,6-dimethyl-5-vinyl-9,10-dihydrophenanthren-7-ol can be isolated from Juncus compressus. 2-Methoxy-1,6-dimethyl-5-vinyl-9,10-dihydrophenanthren-7-ol exhibits anticancer activity against cervical and ovarian cancers. 2-Methoxy-1,6-dimethyl-5-vinyl-9,10-dihydrophenanthren-7-ol can be used for HSV-2 virus research .

HY-N16455

(S)-2-Hydroxy-3-decanone	Natural Products Animals Source classification	Insecticide
(S)-2-Hydroxy-3-decanone is the primary sex pheromone component of Xylotrechus quadripes beetles, functioning as a volatile olfactory agonist. (S)-2-Hydroxy-3-decanone is promising for research of pests and diseases .

HY-N16456

3-Hydroxy-2-decanone	Natural Products Animals Source classification	Insecticide
3-Hydroxy-2-decanone is a minor component of sex pheromone in Xylotrechus quadripes beetles. 3-Hydroxy-2-decanone is promising for research of pests and diseases .

HY-113110R

Cysteinylglycine (Standard)	Natural Products Human Gut Microbiota Metabolites Microorganisms Source classification Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite	Endogenous Metabolite
Cysteinylglycine (Standard) is the analytical standard of Cysteinylglycine. This product is intended for research and analytical applications. Cysteinylglycine is a dipeptide produced by the decomposition of extracellular glutathione catalyzed by γ-glutamyl transpeptidase. Cysteinylglycine is a highly reactive metabolite. Cysteinylglycine is currently mainly used in neurodegenerative diseases and breast cancer research .

HY-129566R

Withanolide B (Standard)	Source classification Withania somnifera Solanaceae Plants Steroids	Reference Standards ERK Wnt β-catenin RUNX
Withanolide B (Standard) is the analytical standard of Withanolide B. This product is intended for research and analytical applications. Withanolide B is an active component of W. somnifera Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2 and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects .

HY-111038

Capsiconiate Coniferyl (E)-8-methyl-6-nonenoate	Monophenols Source classification Phenols Plants Solanaceae Capsicum baccatum L.	TRP Channel
Capsiconiate (Coniferyl (E)-8-methyl-6-nonenoate) is a TRPV1 agonist (EC₅₀= 3.2 μM). Capsiconiate can be used to study TRPV1-mediated diseases such as pain, inflammation, and epilepsy(EC₅₀= 3.2 μM) .

HY-W713570

Nectandrin B	Monophenols Saururaceae Saururus chinensis (Lour.) Baill. Source classification Phenols Plants	Topoisomerase
Nectandrin B is an inhibitor of DNA topoisomerases I and II, which is found in Saururus chinensis. Nectandrin B is promising for research of cancers .

HY-Y1819R

2-Acetonaphthone (Standard)	Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Reactive Oxygen Species (ROS) Mitochondrial Metabolism
2-Acetonaphthone is a synthetic fragrance material. 2-Acetonaphthone increases ROS under UVA/sunlight, leading to endoplasmic reticulum stress and decreased mitochondrial membrane potential. 2-Acetonaphthone can be used as an adulterant in a variety of cosmetics. 2-Acetonaphthone can be used for the study of skin keratinization

HY-N15184

Benanomicin B Pradimicin C	Microorganisms Antibiotics Source classification	Bacterial Fungal
Benanomicin B (Pradimicin C) is an antifungal antibiotic that also has antibacterial activity against two Gram-positive bacteria: Micrococcus luteus and Corynebacterium bovis .

HY-Y1819

2-Acetonaphthone 1 Publications Verification	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Reactive Oxygen Species (ROS) Mitochondrial Metabolism
2-Acetonaphthone is a synthetic fragrance material. 2-Acetonaphthone increases ROS under UVA/sunlight, leading to endoplasmic reticulum stress and decreased mitochondrial membrane potential. 2-Acetonaphthone can be used as an adulterant in a variety of cosmetics. 2-Acetonaphthone can be used for the study of skin keratinization

HY-N1189

DL-Syringaresinol diacetate Syringaresinol Diacetate	Natural Products Source classification Plants Menispermaceae	Others
DL-Syringaresinol diacetate is a glucoside. DL-Syringaresinol inhibits cAMP phosphodiesterase and alleviation of stress .

HY-N9248

6-Hydroxywogonin	Flavonoids Microorganisms Flavones Source classification	Others
6-Hydroxywogonin (compound 26) is a flavonoid compound .

HY-N15570

2-O-Methylatromentin	Microorganisms Source classification Phenols Polyphenols	Interleukin Related TNF Receptor
2-O-Methylatromentin is an anti-neuroinflammatory agent. 2-O-Methylatromentin shows inhibitory activity on the production of pro-inflammatory cytokines TNF-α, IL-6 and IL-1β in Lipopolysaccharides (HY-D1056) (LPS) -induced BV-2 microglial cells. 2-O-Methylatromentin can be used for the study of neuroinflammatory related diseases .

HY-P2363

Leucinostatin K	Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Bacterial Fungal
Leucinostatin K is a peptide antibiotic with anti-gram-positive bacterial and fungal effects, which is found in Paecilomyces lilacinus .

HY-Y0520

Itaconic acid 2 Publications Verification Methylenesuccinic acid	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite Ferroptosis
Itaconic acid, a precursor of polymers, chemicals, and fuels, can be synthesized by many fungi. Itaconic acid also is a macrophage-specific metabolite. Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors. Itaconic acid has anti-inflammatory, anti-microbial and immunomodulatory effect ^[5].

HY-W230975

(E/Z)-Piperine (E/Z)-Bioperine; (E/Z)-1-Piperoylpiperidine	Alkaloids Piperidine Alkaloids Source classification Piperaceae Plants Piper nigrum Linn.	Cytochrome P450 P-glycoprotein
(E/Z)-Piperine ((E/Z)-Bioperine) is an alkaloid with a pungent property. (E/Z)-Piperine shows anti-inflammation, immunomodulatory and anti-cancer, antispasmodic and anti-secretory effects. (E/Z)-Piperine demonstrates significant neuroprotective effect in Alzheimer’s disease and Parkinson’s disease .

HY-N12400

10-Methyldodec-2-en-4-olide	Natural Products Microorganisms Source classification	Bacterial
10-Methyldodec-2-en-4-olide is a antibacterial agent and can be isolated from Streptomyces. 10-Methyldodec-2-en-4-olide shows antibacterial activity against B. cinerea, the yeast S. cerevisiae, bacteria S. aureus, and M. luteus .

Cat. No.	Product Name	Chemical Structure

HY-Z5058S

(3R,5S)-Fluvastatin-d7 sodium
(3R,5S)-Fluvastatin-d₇ (sodium) is the deuterium labeled (3R,5S)-Fluvastatin sodium .

HY-W699829

(3R,5R)-Rosuvastatin Lactone-d6
(3R,5R)-Rosuvastatin Lactone-d₆ is the deuterium labeled (3R,5R)-Rosuvastatin Lactone (HY-135406). (3R,5R)-Rosuvastatin Lactone is an isomer of Rosuvastatin Lactone.

HY-141723S

(4R,5R)-5-(2,4-Difluorophenyl)-4-methyl-5-(1H-1,2,4-triazol-1-ylmethyl)-2-oxazolidinone-d3
(4R,5R)-5-(2,4-Difluorophenyl)-4-methyl-5-(1H-1,2,4-triazol-1-ylmethyl)-2-oxazolidinone-d₃ is the deuterium labeled (4R,5R)-5-(2,4-Difluorophenyl)-4-methyl-5-(1H-1,2,4-triazol-1-ylmethyl)-2-oxazolidinone .

HY-W040240S

(3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one-13C
(3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one- ¹³C is the ¹³C labeled (3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one. (3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one is an endogenous metabolite .

HY-146708S

((2R,3S,4R,5R)-5-(2-Amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate-15N4 sodium
((2R,3S,4R,5R)-5-(2-Amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate- ¹⁵N₄ (sodium) is a ¹⁵N-labeled ((2R,3S,4R,5R)-5-(2-Amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate (so

HY-W040240S2

(3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one-13C-2
(3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one- ¹³C-2 is the ¹³C labeled (3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one. (3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one is an endogenous metabolite .

HY-W040240S1

(3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one-13C-1
(3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one- ¹³C-1 is the ¹³C labeled (3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one. (3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one is an endogenous metabolite .

HY-W011090S

((2R,3S,4R,5R)-5-(4-Amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate-13C9,15N3 sodium
((2R,3S,4R,5R)-5-(4-Amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate- ¹³C₉, ¹⁵N₃ (sodium) is the ¹³C and ¹⁵N labeled Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate .

HY-W722122

N-(1-(Adamantan-1-yl)ethyl)hydroxylamine-d4
N-(1-(Adamantan-1-yl)ethyl)hydroxylamine-d₄ (N-(1-((3r,5r,7r)-Adamantan-1-yl)ethyl)hydroxylamine-d₄) is the deuterium labeled N-(1-(adamantan-1-yl)ethyl)hydroxylamine (HY-75864).

HY-N1459S

(24Rac)-Campesterol-d7
Campesterol-d₇ ((24R)-5-Ergosten-3β-ol-d₇) is the deuterium labeled Campesterol. Campesterol is a plant sterol with cholesterol lowering and anticarcinogenic effects.

HY-132485S

*N-Methyl Pantoprazole-d3 (Mixture of 1 and* 3 isomers)**
N-Methyl Pantoprazole-d₃ (Mixture of 1 and 3 isomers) is the deuterium labeled N-Methyl Pantoprazole (Mixture of 1 and 3 isomers) .

HY-146909S

CER5-2’R-d9
CER5-2’R-d₉ is deuterium labeled CER5-2’R.

HY-108226S1

*Regorafenib N-oxide and* N-desmethyl (M5)-13C6**
Regorafenib N-oxide and N-desmethyl (M5)- ¹³C₆ is the ¹³C-labeled Regorafenib N-oxide and N-desmethyl (M5) .

HY-W714797

Nintedanib demethyl-O-glucuronic acid-d3
Nintedanib demethyl-O-glucuronic acid-d₃ is the deuterium labeled (2R,3R,4R,5S,6S)-3,4,5-Trihydroxy-6-(((Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carbonyl)oxy)tetrahydro-2H-pyran-2-carboxylic acid (HY-W712456).

HY-W753480

Phenol rutinoside-d5
Phenol rutinoside-d₅ is the deuterium labeled (2S,3R,4R,5R,6R)-2-Methyl-6-(((2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-phenoxytetrahydro-2H-pyran-2-yl)methoxy)tetrahydro-2H-pyran-3,4,5-triol (HY-W725466).

HY-108226S

*Regorafenib N-oxide and* N-desmethyl (M5)-d3**
Regorafenib N-oxide and N-desmethyl (M5)-d₃ is deuterium labeled Regorafenib N-oxide and N-desmethyl (M5).

HY-W709612

*Regorafenib N-oxide and* N-desmethyl (M5)-d3-1**
Regorafenib N-oxide and N-desmethyl (M5)-d₃-1 (N-Desmethyl regorafenib N-oxide-d₃-1) is the deuterium labeled Regorafenib N-oxide and N-desmethyl (M5) (HY-108226). Regorafenib N-oxide and N-desmethyl (M5) (N-Desmethyl regorafenib N-oxide) is an active metabolite of Sorafenib (HY-10201) and can be metabolized by CYP3A4 .

HY-17479S

Amfenac-d5
Amfenac-d₅ is the deuterium labeled Amfenac. Amfenac is an orally active and potent anti-inflammatory compound possessing antipyretic and analgesic properties. Amfenac can be used for the research of acute and chronic inflammation .

HY-17479BS

Amfenac-d5 sodium
Amfenac-d₅ sodium is deuterated-labeled Amfenac sodium. Amfenac Sodium is an orally active and potent anti-inflammatory compound possessing antipyretic and analgesic properties. Amfenac Sodium can be used for the research of acute and chronic inflammation .

HY-P0090S

Calcitonin-13C6,15N4 (salmon) TFA
Calcitonin- ¹³C₆, ¹⁵N₄ (salmon) (Salmon calcitonin- ¹³C₆, ¹⁵N₄) TFA is ¹³C and ¹⁵N-labeled Calcitonin (salmon) (HY-P0090). Calcitonin (salmon) , a calcium regulating hormone, is a dual-action amylin and calcitonin receptor agonist, could stimulate bone formation and inhibit bone resorption .

HY-Y0921S3

(±)-1,2-Propanediol-13C3
(±)-1,2-Propanediol- ¹³C₃ is ¹³C labeled (±)-1,2-Propanediol (HY-Y0921). (±)-1, 2-propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol that is often used as an excipient in many active molecular preparations to increase the solubility and stability of the active molecule. (±)-1, 2-propanediol can affect the neurobehavior of zebrafish .

HY-Y0882S1

Hydroxylamine-d3 hydrochloride

Hydroxylamine-d₃ (hydrochloride) is the deuterium labeled Hydroxyamine hydrochloride. Hydroxylamine hydrochloride is a selective Monoamine oxidase (MAO) inhibitor used for inhibiting of platelet aggregation. Hydroxylamine hydrochloride is an intermediate of nitrogen cycle in aerobic ammonium oxidizers microorganisms, such as ammonium oxidizing bacteria (AOB), ammonium oxidizing archaea (AOA) and complete ammonium oxidizing bacteria (comammox). Hydroxylamine hydrochloride impacts NO and N₂O emissions by aerobic ammonium oxidizers microorganisms and inhibits nitrite oxidizing bacteria (NOB) activity .

HY-B0168AS

Milnacipran-d5 hydrochloride

Milnacipran-d₅ hydrochloride is deuterium labeled Milnacipran hydrochloride (HY-B0168A). Milnacipran hydrochloride is an orally active Serotonin (HY-B1473A) and Norepinephrine (HY-13715) reuptake inhibitor. Milnacipran hydrochloride inhibits monoamine transporters, especially the norepinephrine transporter and the serotonin transporter (K_i values of 31 and 8.5 nM, respectively). Milnacipran hydrochloride inhibits pERK1/2 activation. Milnacipran hydrochloride has antidepressant, anxiolytic and analgesic properties. Milnacipran hydrochloride inhibits biting behavior in mice. Milnacipran hydrochloride can be used in the study of major depressive disorder, anxiety disorders, and neuropathic pain (e.g., fibromyalgia) ^[5] .

HY-W585933S

Fructose-alanine-13C6

Fructose-alanine- ¹³C₆ is ¹³C labeled Fructose-alanine. Fructose-alanine, an amadori compound, is an aroma precursor that formed in the initial phase of the Maillard reaction (MR). Fructose-alanine can be isolated from tobacco, miso and white wine. Fructose-alanine significantly induces oxidative browning and correlates with Maillard product (furfuryl alcohol) with a roasted and sweet aroma. Fructose-alanine can be used for food industry and tobacco processing research .

HY-B2221S1

U-13C Cellulose from chicory

U- ¹³C Cellulose from chicory is the ¹³C labeled Cellulose (HY-B2221). Cellulose (Pectin glycosidase) is a natural high molecular weight polysaccharide found in many plants and organisms. It is widely used in manufacturing industries, such as in paper making, textiles, food and medicine, etc. As a renewable resource, Cellulose is biodegradable and sustainable, and can also be used to manufacture chemicals such as Cellulose Esters, Cellulose Acetate and Cellulose Nitrate. In addition, Cellulose is often used as a food additive to increase the stability and quality of food .

HY-B1234S

Octinoxate-13C,d3

Octinoxate-13C,d3 is the deuterium labeled Octinoxate (HY-W245806). Octinoxate (Octyl methoxycinnamate) is a thyroid hormone receptor agonist, reducing the levels of triiodothyronine (T3) and thyroxine (T4) and transcription levels of genes related to type II deiodinase (deio2) in Japanese Medaka. Octinoxate is commonly used as a safe ultraviolet (UV) filter used in the aquatic environment. Octinoxate inhibits CYP1A1 and CYP1B1 to regulate hyaluronan (HA) (HY-B0633A) metabolism in a PI3K pathway-dependent manner in human keratinocytes. Octinoxate also exhibits an anti-estrogenic and anti-androgenic effect in vitro and in vivo ^[5].

HY-B2221S

U-13C Cellulose high DP from potato

U- ¹³C Cellulose high DP from potato is the ¹³C labeled Cellulose (HY-B2221). Cellulose (Pectin glycosidase) is a natural high molecular weight polysaccharide found in many plants and organisms. It is widely used in manufacturing industries, such as in paper making, textiles, food and medicine, etc. As a renewable resource, Cellulose is biodegradable and sustainable, and can also be used to manufacture chemicals such as Cellulose Esters, Cellulose Acetate and Cellulose Nitrate. In addition, Cellulose is often used as a food additive to increase the stability and quality of food .

HY-B2221S3

U-13C Cellulose high DP from maize

U- ¹³C Cellulose high DP from maize is the ¹³C labeled Cellulose (HY-B2221). Cellulose (Pectin glycosidase) is a natural high molecular weight polysaccharide found in many plants and organisms. It is widely used in manufacturing industries, such as in paper making, textiles, food and medicine, etc. As a renewable resource, Cellulose is biodegradable and sustainable, and can also be used to manufacture chemicals such as Cellulose Esters, Cellulose Acetate and Cellulose Nitrate. In addition, Cellulose is often used as a food additive to increase the stability and quality of food .

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