2. Others Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Biochemical Assay Reagents Apoptosis Reactive Oxygen Species (ROS) Bcl-2 Family Caspase
  4. Carboxymethyl chitosan

Carboxymethyl chitosan is a derivative of chitosan. Carboxymethyl chitosan inhibits Apoptosis and ROS. Carboxymethyl chitosan increases the expression of Bcl-2 and reduces the expression of Bax, cytochrome c and caspase-3. Carboxymethyl chitosan inhibits the migration of various cells. Carboxymethyl chitosan exerts antitumor effects on Lewis tumors and hepatocarcinoma.

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Carboxymethyl chitosan Chemical Structure

Carboxymethyl chitosan Chemical Structure

CAS No. : 83512-85-0

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Carboxymethyl chitosan Related Antibodies

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Description

Carboxymethyl chitosan is a derivative of chitosan. Carboxymethyl chitosan inhibits Apoptosis and ROS. Carboxymethyl chitosan increases the expression of Bcl-2 and reduces the expression of Bax, cytochrome c and caspase-3. Carboxymethyl chitosan inhibits the migration of various cells. Carboxymethyl chitosan exerts antitumor effects on Lewis tumors and hepatocarcinoma[1][2][3][4][5][6][7][8].

IC50 & Target[1][2][3][4][5][6][7][8]

Bax

 

Bcl-2

 

Caspase-3

 

In Vitro

Carboxymethyl chitosan (100 μg/mL; 4 days) promotes the proliferation of normal skin fibroblasts but inhibits the proliferation of keloid fibroblasts[1].
Carboxymethyl chitosan hydrogels show enhanced cell migration compared with standard chitosan hydrogels[2].
Carboxymethylated chitosan (50-200 μg/mL; 8 h) increases the viability of Schwann cells exposed to H2O2 and decreases LDH release in a concentration-dependent manner[3].
Carboxymethyl chitosan (0.5-2.0 mg/mL; 24-48 h) significantly inhibits the migration of human umbilical vein endothelial cells (HUVECs)[4].
Carboxymethyl chitosan (50-200 μg/mL; 1 h) inhibits IL-1β-induced apoptosis of rabbit chondrocytes in a dose-dependent manner[5].
Carboxymethyl chitosan (4.0-5.0 mg/mL; 48 h) decreases viability of OS-RC-2, NCI-H1650, and HT-29 cells[6].
Carboxymethyl chitosan (1.0-5.0 mg/mL; 12-24 h) can significantly inhibit the two-dimensional migration of BEL-7402 cells in a dose-dependent manner[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Carboxymethyl chitosan Related Antibodies

Apoptosis Analysis[3]

Cell Line: Schwann cells
Concentration: 5, 100, 200 μg/mL
Incubation Time: 8 h
Result: Increased the expression of the anti-apoptotic protein Bcl-2 and decreased the expression of the pro-apoptotic proteins Bax, cytochrome c, and caspase-3.
Reduced cell apoptosis rates by 45.9%, 23.2%, and 9.3% at concentrations of 5 μg/mL, 100 μg/mL, and 200 μg/mL, respectively.
In Vivo

Carboxymethyl chitosan (75-300 mg/kg; i.p.; administered on days 1, 3, 5, 7, 9, 11, 13) represses tumor angiogenesis in a mouse hepatocarcinoma H22-bearing tumor model[4].
Carboxymethyl chitosan (20-120 mg/kg; i.v.; every other day; for seven times) can significantly inhibit the growth of Lewis tumor tissue, increase the spleen index of tumor-bearing mice, and make the liver and lung cells arrange more orderly, indicating its effectiveness in repressing Lewis tumor growth and metastasis[6].
Carboxymethyl chitosan (1350 mg/kg; i.p.) has no significant effects on the coagulation, anticoagulation, fibrinolysis, or hemorheology parameters of rats[8].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Kunming mice (female, 18-22 g, 6-8 weeks old); Mouse hepatocarcinoma H22-bearing tumor model[4]
Dosage: 75 mg/kg, 150 mg/kg, 300 mg/kg (dissolved in normal saline)
Administration: Intraperitoneal injection, administered on days 1, 3, 5, 7, 9, 11, 13
Result: Inhibited the growth of H22 tumor tissue.
Showed inhibition rates of 32.63%, 51.43% and 29.89% at doses of 75 mg/kg, 150 mg/kg and 300 mg/kg, respectively.
Decreased CD34, VEGF and increased TIMP-1.
Increased the thymus index and spleen index of the mice, and enhanced serum IFN-γ and TNF-α levels.
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Carboxymethyl chitosan]
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Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 10 mg/mL (Need ultrasonic)

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Purity & Documentation

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Carboxymethyl chitosan Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Carboxymethyl chitosan83512-85-0Biochemical Assay ReagentsApoptosisReactive Oxygen Species (ROS)Bcl-2 FamilyCaspaseBEL-7402SchwannOS-RC-2NCI-H1650and HT-29hepatocarcinomaLewis tumorInhibitorinhibitorinhibit

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