2. Academic Validation
  3. Carboxymethyl chitosan represses tumor angiogenesis in vitro and in vivo

Carboxymethyl chitosan represses tumor angiogenesis in vitro and in vivo

  • Carbohydr Polym. 2015 Sep 20:129:1-8. doi: 10.1016/j.carbpol.2015.04.040.
Zhiwen Jiang 1,  Baoqin Han 2,  Hui Li 1,  Yan Yang 1,  Wanshun Liu 1
Affiliations

Affiliations

  • 1 Biochemistry Laboratory, College of Marine Life Sciences, Ocean University of China, No. 5 Yushan Road, Qingdao 266003, Shandong, PR China.
  • 2 Biochemistry Laboratory, College of Marine Life Sciences, Ocean University of China, No. 5 Yushan Road, Qingdao 266003, Shandong, PR China. Electronic address: baoqinh@ouc.edu.cn.
PMID: 26050881 DOI: 10.1016/j.carbpol.2015.04.040
Abstract

Carboxymethyl chitosan (CMCS), with potent water solubility, biocompatibility, and non-toxicity, has emerged as a promising candidate for biomedical applications. In this study, the anti-tumor angiogenesis effects of CMCS were evaluated in vitro and in vivo. Our results showed that CMCS could inhibit the 2-dimensional and 3-dimensional migration of human umbilical vein endothelial cells (HUVECs) in vitro. CMCS significantly inhibited the growth of mouse hepatocarcinoma 22 tissues and could promote tumor cell necrosis as suggested by pathological observations. The CD34 expression in H22 tumor tissue, the levels of vascular endothelial growth factor and tissue inhibitor of metalloproteinase 1 in serum was regulated by CMCS treatment. CMCS could significantly improve thymus index, spleen index, tumor necrosis factor α and interferon γ level. In a conclusion, CMCS possessed potent anti-tumor effects by inhibiting tumor angiogenesis, stimulating immune functions. Our date provide more foundation for application of CMCS in biomedicine or biomaterials for targeted Anticancer drugs delivery.

Keywords

Angiogenesis; Anti-tumor; Carboxymethyl chitosan; In vitro; In vivo.

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