2. Academic Validation
  3. Preparation and anti-tumor metastasis of carboxymethyl chitosan

Preparation and anti-tumor metastasis of carboxymethyl chitosan

  • Carbohydr Polym. 2015 Jul 10:125:53-60. doi: 10.1016/j.carbpol.2015.02.039.
Zhiwen Jiang 1,  Baoqin Han 2,  Hui Li 1,  Xiuhua Li 1,  Yan Yang 1,  Wanshun Liu 1
Affiliations

Affiliations

  • 1 Biochemistry Laboratory, College of Marine Life Sciences, Ocean University of China, 5 No. Yushan Road, Qingdao 266003, PR China.
  • 2 Biochemistry Laboratory, College of Marine Life Sciences, Ocean University of China, 5 No. Yushan Road, Qingdao 266003, PR China. Electronic address: baoqinh@ouc.edu.cn.
PMID: 25857959 DOI: 10.1016/j.carbpol.2015.02.039
Abstract

Carboxymethyl chitosan (CMCS), one of the most important water soluble chitosan derivatives, has great potentials in biomedical applications due to its excellent water solubility, biodegradability, biocompatibility, and non-toxicity. In the present study, the anti-tumor metastasis effect of CMCS on hepatic tumors was evaluated using human hepatic Cancer cell BEL-7402 and mouse hepatoma 22 cells. The results suggested that CMCS could significantly inhibit tumor cell migration in vitro, and reduce the expression of matrix metalloproteinase-9 in BEL-7402 cells in a dose-dependent manner (P<0.05). Furthermore, CMCS significantly inhibited the lung metastasis of hepatoma-22 in Kunming mice (P<0.05). Significant improvement of the lung injury caused by the metastasis of H22 was also observed. The results suggested that the inhibitory effect of CMCS could be attributed in part to the decreased levels of vascular endothelial growth factor and E-Selectin in CMCS treated mice.

Keywords

Anti-tumor; Carboxymethyl chitosan; Hepatic; Metastasis.

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