Fibulin-5 Antibody (YA4858)

Fibulin-5 Antibody (YA4858) is a mouse-derived and non-conjugated monoclonal antibody, targeting to Fibulin-5. It can be applicated for WB, IHC-P, ICC/IF, ELISA assays, in the background of human.

Fibulin-5 plays a pivotal role in elastic fiber formation, acting as a crucial contributor to the assembly of continuous elastin (ELN) polymers and facilitating the interaction between microfibrils and ELN. This protein is integral to stabilizing and organizing elastic fibers in various tissues such as the skin, lung, and vasculature, demonstrating its significance in maintaining structural integrity. Additionally, Fibulin-5 serves as a vascular ligand for integrin receptors, suggesting its involvement in vascular development and remodeling. By interacting with ELN, integrins, and forming a ternary complex with FBN1, Fibulin-5 acts as an adapter, orchestrating essential molecular interactions that contribute to the proper assembly and function of elastic fibers. The ability of Fibulin-5 to homodimerize in the presence of Ca(2+) further highlights its structural versatility and functional importance in maintaining tissue integrity and elasticity.

Q9UBX5

Predicted band size: 50 kDa;

affinity purified.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human

WB: 1:500-1:2000; IHC: 1:200-1:1000; ELISA: 1:10000; ICC/IF: 1:50-200

WB, IHC-P, ICC/IF, ELISA

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant fragment of Fibulin-5 expressed in E. Coli.