CCL2 Antibody (YA4962)

CCL2 Antibody (YA4962) is a mouse-derived and non-conjugated monoclonal antibody, targeting to CCL2. It can be applicated for WB, ELISA assays, in the background of human.

CCL2 protein functions as a ligand for C-C chemokine receptor CCR2, initiating a potent chemotactic response and intracellular calcium mobilization through the binding and activation of CCR2. It exhibits chemotactic activity for monocytes and basophils while remaining inactive towards neutrophils or eosinophils. Playing a crucial role in mediating neuropathic pain induced by peripheral nerve injury, CCL2 also enhances NMDA-mediated synaptic transmission in dopamine D1 and D2 receptor-containing neurons, possibly involving MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B. Existing as a monomer or homodimer in equilibrium, it is tethered to endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans and interacts with TNFAIP6 through its Link domain.

P13500

Predicted band size: 11 kDa;

affinity purified.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human

WB: 1:500-1:2000; ELISA: 1:10000

WB, ELISA

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant fragment of human MCP-1 expressed in E. Coli.