MCP1 Antibody (YA4962)

MCP1 Antibody (YA4962) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to MCP1.

CCL2 protein functions as a ligand for C-C chemokine receptor CCR2, initiating a potent chemotactic response and intracellular calcium mobilization through the binding and activation of CCR2. It exhibits chemotactic activity for monocytes and basophils while remaining inactive towards neutrophils or eosinophils. Playing a crucial role in mediating neuropathic pain induced by peripheral nerve injury, CCL2 also enhances NMDA-mediated synaptic transmission in dopamine D1 and D2 receptor-containing neurons, possibly involving MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B. Existing as a monomer or homodimer in equilibrium, it is tethered to endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans and interacts with TNFAIP6 through its Link domain.

P13500

Predicted band size: 11 kDa; Observed band size: 11 kDa

affinity purified

Non-conjugated

Unmodified

Primary Antibody; Monoclonal Antibody

Monoclonal

Mouse

Human, Mouse, Rat, Monkey

WB: 1:500-1:1000; IHC-P: 1:100-1:200; ICC/IF: 1:50-1:200; FC: 1:50-1:100

WB, IHC-P, ICC/IF, FC

Liquid

Supplied in purified antibody in PBS with 0.05% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Endogenous

Purified recombinant fragment of human CCL2 expressed in E. Coli. The exact sequence is proprietary to MCE.