2. Others Immunology/Inflammation
  3. Biochemical Assay Reagents Interleukin Related
  4. Hydroxypropyl Cellulose

Hydroxypropyl Cellulose is an orally active cellulose ether and surfactant. Hydroxypropyl cellulose is divided into high-substituted HPC (HHPC) and low-substituted HPC (LHPC). Hydroxypropyl Cellulose reduces inflammatory mediators (IL-6, IL-1β). Hydroxypropyl Cellulose improves colitis and obesity. Hydroxypropyl Cellulose can be used as a pharmaceutical excipient, such as coating agent, emulsifier, suspension, tablet, thickener, viscosifier.

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Hydroxypropyl Cellulose Chemical Structure

Hydroxypropyl Cellulose Chemical Structure

CAS No. : 9004-64-2

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Based on 1 publication(s) in Google Scholar

Other Forms of Hydroxypropyl Cellulose:

Hydroxypropyl Cellulose Related Antibodies

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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Description

Hydroxypropyl Cellulose is an orally active cellulose ether and surfactant. Hydroxypropyl cellulose is divided into high-substituted HPC (HHPC) and low-substituted HPC (LHPC). Hydroxypropyl Cellulose reduces inflammatory mediators (IL-6, IL-1β). Hydroxypropyl Cellulose improves colitis and obesity. Hydroxypropyl Cellulose can be used as a pharmaceutical excipient, such as coating agent, emulsifier, suspension, tablet, thickener, viscosifier[1][2][3][4].

In Vitro

Hydroxypropyl methylcellulose (HHPC; 12.5-1600 μg/mL; 24 h) promotes the growth of RAW 264.7 cells and inhibits inflammation[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Hydroxypropyl Cellulose Related Antibodies
In Vivo

Hydroxypropyl methylcellulose (150-300 mg/kg; p.o.; 8 days) ameliorates DSS-induced colitis in Balb/c mice[3].
Hydroxypropyl methylcellulose (6% in diet; p.o.; 5 weeks) ameliorates the effects of a high-fat diet on intestinal permeability, insulin resistance, hepatic lipid accumulation, glucocorticoid related bile acid recycling, oxidative stress, and weight gain in DIO mice[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/c male mice (DSS-induced colitis model)[3]
Dosage: 150 mg/kg, 300 mg/kg (suspended in water)
Administration: Oral administration, 8 days
Result: Mitigated the pathological damage of colon tissue.
Suppressed spleen edema, preserved thymus index, reduced the serum level of inflammatory mediators (TNF-α, IL-6, IL-1β, and MPO).
Increased the secretion of sIgA in the colon, and restored the balance of the intestinal flora.
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CO[C@H]1C(O[R])[C@@H](O[R])[C@H](C)O[C@@H]1CO[R].[n].[R=H or CH2CH(OH)CH3]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (Need ultrasonic)

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This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥97.0%

SDS (393 KB)

COA (255 KB)

Handling Instructions (2659 KB)
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Hydroxypropyl Cellulose Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hydroxypropyl Cellulose9004-64-2Biochemical Assay ReagentsInterleukin RelatedILpharmaceutical excipientpharmaceutical auxiliariepharmaceutical ingredientsinactive ingredientsstabilitysolubilityprocessabilityabsorptiondistributionmetabolismand elimination (ADME)Inhibitorinhibitorinhibit

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