2. Academic Validation
  3. The potential therapeutic effects of hydroxypropyl cellulose on acute murine colitis induced by DSS

The potential therapeutic effects of hydroxypropyl cellulose on acute murine colitis induced by DSS

  • Carbohydr Polym. 2022 Aug 1:289:119430. doi: 10.1016/j.carbpol.2022.119430.
Xuefeng Li 1,  Huixia Lv 2,  Fanli Shi 2,  Jie Song 3,  Zhenhai Zhang 4
Affiliations

Affiliations

  • 1 Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, 211198 Nanjing, China. Electronic address: 3319010363@stu.cpu.edu.cn.
  • 2 Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, 211198 Nanjing, China.
  • 3 Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, 210023 Nanjing, China; Jiangsu Province Academy of Traditional Chinese Medicine, 210028 Nanjing, China. Electronic address: songjie_pharmacy@163.com.
  • 4 Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, 210023 Nanjing, China; Jiangsu Province Academy of Traditional Chinese Medicine, 210028 Nanjing, China. Electronic address: david23932@163.com.
PMID: 35483843 DOI: 10.1016/j.carbpol.2022.119430
Abstract

In this study, high-substituted hydroxypropyl cellulose (HHPC) and low-substituted hydroxypropyl cellulose (LHPC) were orally administered (150 or 300 mg/kg) to investigate the inflammation inhibitory effects on DSS-induced colitis mice. In addition, the anti-inflammatory potential of HHPC in-vitro (RAW 264.7 cells) was evaluated. The result showed that HHPC could inhibit the excessive secretion of TNF-α, IL-6, and NO in RAW 264.7 cells induced by lipopolysaccharide. Oral administration of HHPC and LHPC could dose-dependently mitigate the pathological damage of colon tissue, suppressed spleen edema, preserved thymus index, reduced the serum level of inflammatory mediators (TNF-α, IL-6, IL-1β, and MPO), increased the secretion of sIgA in the colon, and restored the balance of the intestinal flora such as Rikenellaceae_RC9_gut_group, Lachnospiraceae_UCG-006, and Blautia. Overall, this study elucidated the therapeutic potential of LHPC and HHPC as a prebiotic to treat acute ulcerative colitis.

Keywords

Anti-inflammatory; Cytokines; Hydroxypropyl cellulose; Intestinal flora; RAW264.7 cells; Ulcerative colitis.

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