2. Cell Cycle/DNA Damage Apoptosis
  3. CDK Apoptosis
  4. Avotaciclib sulfate

Avotaciclib sulfate  (Synonyms: BEY1107 sulfate)

Cat. No.: HY-137432D
Handling Instructions Technical Support

Avotaciclib (BEY1107) sulfate is an orally active cyclin-dependent kinase 1 (CDK1) inhibitor. Avotaciclib sulfate can inhibit the proliferation and induce apoptosis of tumor cells. Avotaciclib sulfate can be used in the research of cancer such as pancreatic cancer and lung cancer.

For research use only. We do not sell to patients.

Avotaciclib sulfate Chemical Structure

Avotaciclib sulfate Chemical Structure

CAS No. : 1983984-04-8

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Other Forms of Avotaciclib sulfate:

Avotaciclib sulfate Related Antibodies

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

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Description

Avotaciclib (BEY1107) sulfate is an orally active cyclin-dependent kinase 1 (CDK1) inhibitor. Avotaciclib sulfate can inhibit the proliferation and induce apoptosis of tumor cells. Avotaciclib sulfate can be used in the research of cancer such as pancreatic cancer and lung cancer[1][2].

IC50 & Target[1]

CDK1

 

In Vitro

Avotaciclib (0-64 μM; 48 h) sulfate can inhibit cell proliferation and promote apoptosis in radiotherapy-resistant non-small cell lung cancer cell lines, and the effect is better when combined with PV-1019 (HY-125203)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Avotaciclib sulfate Related Antibodies

Cell Viability Assay[2]

Cell Line: Non-small cell lung cancer cells (H1437R, H1568R, H1703R and H1869R)
Concentration: 0, 0.1, 1, 2, 4, 8, 16, 32 and 64 μM
Incubation Time: 48 h
Result: Inhibited the cell viability, with EC50 values of 0.918, 0.580, 0.735 and 0.662 μM for H1437R, H1568R, H1703R and H1869R, respectively.
Clinical Trial
Molecular Weight

379.35

Formula

C13H13N7O5S
CAS No.
SMILES

OC1=CC=C(C2=NC(N)=NC=C2)N=C1C3=NC(N)=NC=C3.O=S(O)(O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Avotaciclib sulfate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Avotaciclib1983984-04-8BEY1107BEY 1107BEY-1107CDKApoptosisCyclin dependent kinaseorallyactivecyclindependentkinasecancerNon-small cell lung cancer cells (H1437RH1568RH1703R and H1869R)Inhibitorinhibitorinhibit

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