ZIP9 Antibody (YA5479)

ZIP9 Antibody (YA5479) is a mouse-derived and non-conjugated monoclonal antibody, targeting to ZIP9. It can be applicated for WB, IHC-P assays, in the background of human, mouse, rat.

ZIP9 is a transmembrane transporter protein primarily responsible for transporting zinc ions across cell and organelle membranes into the cytoplasm and regulating intracellular zinc homeostasis. It participates in the efflux of zinc ions from secretory compartments and enhances AKT1 and MAPK3/MAPK1 (Erk1/2) phosphorylation in response to BCR activation by modulating intracellular zinc levels. Additionally, ZIP9 functions as a membrane androgen receptor, mediating a non-classical androgen signaling pathway via a G protein, which activates MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1 (by similar), thereby promoting CLDN1 and CLDN5 expression and tight junction formation between adjacent Sertoli cells (by similar). ZIP9 also mediates androgen-induced vascular endothelial cell proliferation by activating an inhibitory G protein (Gi), leading to AKT1 and MAPK3/MAPK1 (Erk1/2) activation, which in turn modulates GSK3B phosphorylation and CCND1 transcriptional inhibition. Furthermore, ZIP9 has dual roles as a membrane-bound androgen receptor and an androgen-dependent zinc transporter, both mediated through an inhibitory G protein (Gi) that orchestrates MAP kinase and zinc signaling, ultimately driving androgen-dependent apoptosis.

Q9NUM3

Observed band size: 33 kDa

affinity chromatography.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human, Mouse, Rat

WB: 1:500-2000; IHC: 1:50-200

WB, IHC-P

Liquid

Supplied in PBS containing 50% glycerol, and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Synthesized peptide derived from human Zip9