Cysteinylglycine

Name: Cysteinylglycine
Brand: MedChemExpress
SKU: HY-113110
Rating: 4.5 (1 reviews)

Cat. No.: HY-113110 Purity: 99.96%: Data Sheet
SDS

COA
Handling Instructions
FAQs
Technical Support

Cysteinylglycine is a dipeptide produced by the decomposition of extracellular glutathione catalyzed by γ-glutamyl transpeptidase. Cysteinylglycine is a highly reactive metabolite. Cysteinylglycine is currently mainly used in neurodegenerative diseases and breast cancer research.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Cysteinylglycine Chemical Structure

CAS No. : 19246-18-5

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Cysteinylglycine:

Cysteinylglycine TFA In-stock
Cysteinylglycine (Standard) Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Human Endogenous Metabolite

Cellular Effect

Cell Line	Type	Value	Description	References
KB 3-1	IC₅₀	9.42 mM Compound: Cys-Gly	Cytotoxicity against human KB-3-1 cells incubated for 72 hrs by MTT assay Cytotoxicity against human KB-3-1 cells incubated for 72 hrs by MTT assay	[PMID: 21657271]
KB-V1	IC₅₀	4.23 mM Compound: Cys-Gly	Cytotoxicity against drug-resistant human KBV1 cells expressing P-gp incubated for 72 hrs by MTT assay Cytotoxicity against drug-resistant human KBV1 cells expressing P-gp incubated for 72 hrs by MTT assay	[PMID: 21657271]

Molecular Weight

178.21

Formula

C₅H₁₀N₂O₃S

CAS No.

19246-18-5

Appearance

Solid

Color

White to off-white

Structure Classification

Others

Initial Source

Microorganisms

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light, under nitrogen

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility

In Vitro:

H₂O : 175 mg/mL (981.99 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.6114 mL	28.0568 mL	56.1136 mL
5 mM	1.1223 mL	5.6114 mL	11.2227 mL
10 mM	0.5611 mL	2.8057 mL	5.6114 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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mg/kg

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.96%

Select Batch:

Data Sheet (270 KB) SDS (761 KB)

COA (244 KB) HNMR (248 KB) RP-HPLC (246 KB) MS (68 KB)

Handling Instructions (2659 KB)

References

[1]. Houghton SC, et al. Plasma B-vitamin and one-carbon metabolites and risk of breast cancer before and after folicacid fortification in the United States. Int J Cancer. 2019 Apr 15;144(8):1929-1940. [Content Brief]

[2]. Steele M L, et al. Effect of Nrf2 activators on release of glutathione, cysteinylglycine and homocysteine by human U373 astroglial cells. Redox biology, 2013, 1(1): 441-445.

[3]. Mansoor MA, et al. Determination of the in vivo redox status of cysteine, cysteinylglycine, homocysteine, and glutathione in human plasma. Anal Biochem. 1992 Feb 1;200(2):218-29. [Content Brief]

[4]. Lin J, et al. Plasma cysteinylglycine levels and breast cancer risk in women. Cancer Res. 2007 Dec 1;67(23):11123-7. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	5.6114 mL	28.0568 mL	56.1136 mL	140.2839 mL
	5 mM	1.1223 mL	5.6114 mL	11.2227 mL	28.0568 mL
	10 mM	0.5611 mL	2.8057 mL	5.6114 mL	14.0284 mL
	15 mM	0.3741 mL	1.8705 mL	3.7409 mL	9.3523 mL
	20 mM	0.2806 mL	1.4028 mL	2.8057 mL	7.0142 mL
	25 mM	0.2245 mL	1.1223 mL	2.2445 mL	5.6114 mL
	30 mM	0.1870 mL	0.9352 mL	1.8705 mL	4.6761 mL
	40 mM	0.1403 mL	0.7014 mL	1.4028 mL	3.5071 mL
	50 mM	0.1122 mL	0.5611 mL	1.1223 mL	2.8057 mL
	60 mM	0.0935 mL	0.4676 mL	0.9352 mL	2.3381 mL
	80 mM	0.0701 mL	0.3507 mL	0.7014 mL	1.7535 mL
	100 mM	0.0561 mL	0.2806 mL	0.5611 mL	1.4028 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.