STAT5B Antibody (YA5880)

STAT5B Antibody (YA5880) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Stat5b. It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human, mouse, rat.

STAT5B, a multifunctional protein, orchestrates signal transduction and transcriptional activation, playing a pivotal role in cellular responses to various stimuli, including the cytokine KITLG/SCF and other growth factors. Functioning as a transcription factor, STAT5B binds to the GAS element and facilitates PRL-induced transcription, positively regulating hematopoietic/erythroid differentiation. Upon activation, it forms homodimers and heterodimers with related family members, contributing to its diverse functional roles. Additionally, STAT5B engages in protein-protein interactions, including binding to NR3C1 and forming complexes with NCOA1, NMI, and SOCS7. Notably, its interaction with INSR, facilitated by the SH2 domain, highlights its involvement in insulin signaling. Moreover, the interaction with CPEB3 serves to inhibit STAT5B-mediated transcriptional activation, adding a layer of regulatory complexity to its diverse cellular functions.

P51692

Predicted band size: 90 kDa; Observed band size: 90 kDa

Protein A

Non-conjugated

Unmodified

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Monoclonal

Rabbit

Human, Mouse, Rat

IHC: 1:1000-1:5000; WB: 1:2000-1:10000; ICC/IF: 1:200-1:1000; ELISA: 1:5000-1:20000; IP: 1:50-1:200;

WB, IHC-P, ICC/IF, IP, ELISA

Liquid

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG