2. Metabolic Enzyme/Protease Cell Cycle/DNA Damage Autophagy Apoptosis
  3. Endogenous Metabolite PERK Atg8/LC3 Autophagy Bcl-2 Family Apoptosis Eukaryotic Initiation Factor (eIF) ATF6
  4. L-Azetidine-2-carboxylic acid (Standard)

L-Azetidine-2-carboxylic acid (Standard) 

Cat. No.: HY-W050044R
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L-Azetidine-2-carboxylic acid is a proline analog. L-Azetidine-2-carboxylic acid upregulates the lipid autophagy marker LC3-II via activation of the PERK pathway. L-Azetidine-2-carboxylic acid increases pro-apoptotic BAX protein. L-Azetidine-2-carboxylic acid induces ATF6 cleavage and upregulates phosphorylated eIF2α levels. L-Azetidine-2-carboxylic acid induces ER stress, inducing protein misfolding and aggregation. L-Azetidine-2-carboxylic acid shows teratogenic, pro-inflammatory and pro-apoptotic effects.

For research use only. We do not sell to patients.

L-Azetidine-2-carboxylic acid (Standard)

L-Azetidine-2-carboxylic acid (Standard) Chemical Structure

CAS No. : 2133-34-8

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SMILES

O=C([C@H]1NCC1)O
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L-Azetidine-2-carboxylic acid (Standard) Related Classifications

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  • Do most proteins show cross-species activity?

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Keywords:

L-Azetidine-2-carboxylic acid (Standard)2133-34-8Endogenous MetabolitePERKAtg8/LC3AutophagyBcl-2 FamilyApoptosisEukaryotic Initiation Factor (eIF)ATF6Protein kinase R-like endoplasmic reticulum kinasePKR-like endoplasmic reticulum kinaseAutophagy-related 8Activating transcription factor 6HeLahamsterratsBV2teratogenic pro-inflammatory and pro-apoptoticInhibitorinhibitorinhibit

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