Acyclovir triphosphate sodium  (Synonyms: AcycloGTP sodium)

Acyclovir triphosphate (Synonyms: AcycloGTP) sodium is a Acyclovir (HY-17422) derivative that competitively inhibits viral DNA polymerase by acting as an analog to deoxyguanosine triphosphate (dGTP). Acyclovir triphosphate sodium is an inhibitor of HIV-1 reverse transcriptase. Acyclovir triphosphate sodium causes termination of viral DNA synthesis^[1].

C₈H₁₄N₅O₁₂P₃.xNa

221119-43-3

Liquid

Colorless to light yellow

O=P(OP(OP(OCCOCN1C(N=C(N)NC2=O)=C2N=C1)(O)=O)(O)=O)(O)O.[x].[Na]

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Hirsch MS, et al. Drug therapy: antiviral agents (second of two parts). N Engl J Med. 1980 Apr 24;302(17):949-53.  [Content Brief]

  [2]. McMahon MA,et al. Consistent inhibition of HIV-1 replication in CD4+ T cells by acyclovir without detection of human herpesviruses. J Virol. 2011 May;85(9):4618-22.  [Content Brief]