Pseudouridine 5'-triphosphate trisodium solution (100mM)  (Synonyms: Pseudo-UTP trisodium solution (100mM))

Pseudouridine 5'-triphosphate (Pseudo-UTP) trisodium solution (100 mM) is a modified ribonucleoside triphosphate. Pseudouridine 5'-triphosphate trisodium solution (100 mM) is substituted for UTP to improve the stability and translation efficiency of mRNA and reduce immunogenicity^[1][2][3][4].

Pseudouridine 5'-triphosphate (7.5 mM) trisodium is completely substituted for UTP to improve the stability and translation efficiency of mRNA and reduce immunogenicity^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

550.09

C₉H₁₂N₂Na₃O₁₅P₃

Liquid

Colorless to light yellow

O=P(O)(O[Na])OP(OP(OC[C@H]1O[C@@H](C(C(N2)=O)=CNC2=O)[C@H](O)[C@@H]1O)(O[Na])=O)(O[Na])=O

Room temperature in continental US; may vary elsewhere.

Solution, -20°C, 2 years

• [1]. Muthian Shanmugasundaram, et al. An Efficient Protection-Free One-Pot Chemical Synthesis of Modified Nucleoside-5'-Triphosphates. Nucleosides Nucleotides Nucleic Acids. 2016 Jul 2;35(7):356-62.  [Content Brief]

  [2]. Steinle H, et al. Incorporation of Synthetic mRNA in Injectable Chitosan-Alginate Hybrid Hydrogels for Local and Sustained Expression of Exogenous Proteins in Cells. Int J Mol Sci. 2018 Apr 27;19(5):1313.  [Content Brief]

  [3]. Golombek S, et al. Intradermal Delivery of Synthetic mRNA Using Hollow Microneedles for Efficient and Rapid Production of Exogenous Proteins in Skin. Mol Ther Nucleic Acids. 2018 Jun 1;11:382-392.  [Content Brief]

  [4]. Khan A, et al. Pseudouridine in RNA: enzymatic synthesis mechanisms and functional roles in molecular biology. Int. J. Environ. Agric. Biotechnol, 2023, 8: 284-300.