2. Neuronal Signaling Stem Cell/Wnt
  3. Notch
  4. Yhhu-3792 hydrochloride

Yhhu-3792 hydrochloride is a Notch activator. Yhhu-3792 hydrochloride enhances the self-renewal capability of neural stem cells (NSCs). Yhhu-3792 hydrochloride promotes the expression of Hes3 and Hes5. Yhhu-3792 hydrochloride increases the spatial and episodic memory abilities of mice. Thhu-3792 can be used for the treatment of neurodegenerative diseases (such as Alzheimer's disease) or for neural regeneration after brain injury .

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Yhhu-3792 hydrochloride

Yhhu-3792 hydrochloride Chemical Structure

CAS No. : 2624336-93-0

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Yhhu-3792 hydrochloride Related Antibodies

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Description

Yhhu-3792 hydrochloride is a Notch activator. Yhhu-3792 hydrochloride enhances the self-renewal capability of neural stem cells (NSCs). Yhhu-3792 hydrochloride promotes the expression of Hes3 and Hes5. Yhhu-3792 hydrochloride increases the spatial and episodic memory abilities of mice. Thhu-3792 can be used for the treatment of neurodegenerative diseases (such as Alzheimer's disease) or for neural regeneration after brain injury[1] [2].

In Vitro

Yhhu-3792 (0.63-2.5 μM, 8 d) hydrochloride increases the number of embryonic hippocampal neural stem cells (NSCs)[1].
Yhhu-3792 (0.63-2.5 μM, 2 d) hydrochloride activates the Notch signaling pathway and promotes the expression of Hes5 and Hes3 in neuro-spheres[1].
Yhhu-3792 (2.5 μM, 7-14 d) hydrochloride fails to significantly increase the proportion or purity of natural killer (NK) cell[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Yhhu-3792 hydrochloride Related Antibodies

Western Blot Analysis[1]

Cell Line: Rats neuro-spheres
Concentration: 0.63, 1.25, 2.5 μM
Incubation Time: 2 d
Result: Increased the expression of Notch1 receptor, nuclear NICD, DLL1 and Jagged2.
Significantly increased the expression of Hes5 and Hes3 proteins.

RT-PCR[1]

Cell Line: Rats neuro-spheres
Concentration: 0.63, 1.25, 2.5 μM
Incubation Time: 2 d
Result: Increased the transcription levels of Hes5 and Hes3.
Significantly enhanced the binding of NICD to the promoters of Hes5 and Hes3.
In Vivo

Yhhu-3792 (10-20 mg/kg, i.p., once daily for 3 weeks) hydrochloride enhances the self-renewal of the hippocampal NSCs and promotes the hippocampal neuro-genesis and improves the spatial learning and memory ability of mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Morris water maze (MWM) assay and fear conditioning (FC) assay established in eight-week-old male C57BL/6 mice[1]
Dosage: 10 and 20 mg/kg
Administration: Intraperitoneal injection (i.p.), once daily for 3 weeks
Result: Expanded the NSCs pool and promoted endogenous neurogenesis in the hippocampal dentate gyrus.
Decreased the escape latency of C57BL/6 mice in the MWM test.
increased the freezing time of mice in the Fear conditioning test.
Molecular Weight

436.93

Formula

C24H25ClN4O2
CAS No.
SMILES

[H]Cl.NC1=C2C(OC3=CC=CC(OC)=C3)=CC=CC2=NC(NC4=CC=C(C(C)C)C=C4)=N1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Yhhu-3792 hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Yhhu-37922624336-93-0Yhhu3792Yhhu 3792NotchNSCsHes3Hes5Dentate gyrusSpatial and episodic memorySelf-renewalInhibitorinhibitorinhibit

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