2. Stem Cell/Wnt
  3. β-catenin
  4. S118

S118 is an orally active sphingosine-1-phosphate receptor 2 (S1P2 receptor) inhibitor. S118 prevents the binding of the S1P2 receptor to dapper1 (Dpr1), reduces the accumulation of β-catenin and blocks the nuclear translocation of the S1P2 receptor, thereby inhibiting inflammation, fibrosis, and epithelial-mesenchymal transition (EMT) and exerting anti-idiopathic pulmonary fibrosis (IPF) activity. S118 is promising for research of idiopathic pulmonary fibrosis.

For research use only. We do not sell to patients.

S118 Chemical Structure

S118 Chemical Structure

CAS No. : 2677041-36-8

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Description

S118 is an orally active sphingosine-1-phosphate receptor 2 (S1P2 receptor) inhibitor. S118 prevents the binding of the S1P2 receptor to dapper1 (Dpr1), reduces the accumulation of β-catenin and blocks the nuclear translocation of the S1P2 receptor, thereby inhibiting inflammation, fibrosis, and epithelial-mesenchymal transition (EMT) and exerting anti-idiopathic pulmonary fibrosis (IPF) activity. S118 is promising for research of idiopathic pulmonary fibrosis[1].

Molecular Weight

446.27

Formula

C19H14Cl2FN7O
CAS No.
SMILES

CN1N=CC2=C1N=C(C=C2C3=CC=C(C=C3)F)NNC(NC4=CC(Cl)=NC(Cl)=C4)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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S118 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

S1182677041-36-8S 118S-118β-cateninBeta cateninS1P2 receptorinflammationfibrosisand epithelial-mesenchymal transitionInhibitorinhibitorinhibit

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