EphA8 Antibody (YA4836)

EphA8 Antibody (YA4836) is a mouse-derived and non-conjugated monoclonal antibody, targeting to EphA8. It can be applicated for WB, ELISA assays, in the background of human.

The EphA8 protein, a receptor tyrosine kinase, engages in promiscuous binding to GPI-anchored ephrin-A family ligands on adjacent cells, initiating contact-dependent bidirectional signaling. The downstream pathway originating from the receptor is termed forward signaling, while the pathway downstream of the ephrin ligand is referred to as reverse signaling. GPI-anchored ephrin-A ligands, including EFNA2, EFNA3, and EFNA5, demonstrate the ability to activate EPHA8 through phosphorylation. EPHA8, in conjunction with EFNA5, may regulate integrin-mediated cell adhesion and migration on fibronectin substrates, as well as neurite outgrowth. In the development of the nervous system, EPHA8 also plays a crucial role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN, which promotes cell adhesion upon activation by EPHA8, and the MAP kinases, contributing to the stimulation of neurite outgrowth.

P29322

Predicted band size: 111 kDa;

affinity purified.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human

WB: 1:500-1:2000; ELISA: 1:10000

WB, ELISA

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant fragment of EphA8 (aa70-150) expressed in E. Coli.