1. Apoptosis Immunology/Inflammation
  2. Caspase Interleukin Related
  3. Perfluorodecanoic acid

Perfluorodecanoic acid  (Synonyms: PFDA)

Cat. No.: HY-W269593 Purity: ≥98.0%
Handling Instructions Technical Support

Perfluorodecanoic acid (PFDA) is a perfluoroalkyl substance (PFAS). Perfluorodecanoic acid induces weight loss and increases liver weight and lipid content in mice. Perfluorodecanoic acid also reduces mRNA expression of the genes encoding IL-1β, IL-18, and cellular inhibitor of apoptosis 2 (cIAP2), as well as caspase-1, -3, and -7 in mouse liver.

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Perfluorodecanoic acid Chemical Structure

Perfluorodecanoic acid Chemical Structure

CAS No. : 335-76-2

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Description

Perfluorodecanoic acid (PFDA) is a perfluoroalkyl substance (PFAS). Perfluorodecanoic acid induces weight loss and increases liver weight and lipid content in mice. Perfluorodecanoic acid also reduces mRNA expression of the genes encoding IL-1β, IL-18, and cellular inhibitor of apoptosis 2 (cIAP2), as well as caspase-1, -3, and -7 in mouse liver[1][2].

IC50 & Target

Caspase-1

 

Caspase 3

 

Caspase-7

 

IL-1β

 

Molecular Weight

514.08

Synonyms

PFDA

Formula

C10HF19O2

CAS No.
Appearance

Solid

SMILES

C(=O)(C(C(C(C(C(C(C(C(C(F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature, keep dry and cool

In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

Ethanol : 100 mg/mL (194.52 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9452 mL 9.7261 mL 19.4522 mL
5 mM 0.3890 mL 1.9452 mL 3.8904 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 1.9452 mL 9.7261 mL 19.4522 mL 48.6306 mL
5 mM 0.3890 mL 1.9452 mL 3.8904 mL 9.7261 mL
10 mM 0.1945 mL 0.9726 mL 1.9452 mL 4.8631 mL
15 mM 0.1297 mL 0.6484 mL 1.2968 mL 3.2420 mL
20 mM 0.0973 mL 0.4863 mL 0.9726 mL 2.4315 mL
25 mM 0.0778 mL 0.3890 mL 0.7781 mL 1.9452 mL
30 mM 0.0648 mL 0.3242 mL 0.6484 mL 1.6210 mL
40 mM 0.0486 mL 0.2432 mL 0.4863 mL 1.2158 mL
50 mM 0.0389 mL 0.1945 mL 0.3890 mL 0.9726 mL
60 mM 0.0324 mL 0.1621 mL 0.3242 mL 0.8105 mL
80 mM 0.0243 mL 0.1216 mL 0.2432 mL 0.6079 mL
100 mM 0.0195 mL 0.0973 mL 0.1945 mL 0.4863 mL
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Perfluorodecanoic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Perfluorodecanoic acid
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