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2308

Inhibitors & Agonists

7

Screening Libraries

26

Fluorescent Dye

50

Biochemical Assay Reagents

130

Peptides

4

MCE Kits

29

Inhibitory Antibodies

377

Natural
Products

109

Isotope-Labeled Compounds

10

Click Chemistry

44

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-119648A
    (E/Z)-CCR-11

    		CD38 Inflammation/Immunology
    (E/Z)-CCR-11 (Comp 12) is a selective CD38 inhibitor, with an IC50 of 20.8 μM against CD38 cyclase. (E/Z)-CCR-11 promotes increases in cellular NAD+ levels and interferon γ .
    (E/Z)-CCR-11
  • HY-12839
    p38 MAPK-IN-1
    10+ Cited Publications

    		 p38 MAPK Autophagy Inflammation/Immunology
    p38 MAPK-IN-1 (Compound 4) is a novel potent and selective inhibitor of p38 MAPK with IC50 of 68 nM. p38 MAPK-IN-1 shows sustained levels, low clearance and good bioavailability.
    p38 MAPK-IN-1
  • HY-119855
    Aildenafil

    Methisosildenafil

    		 Phosphodiesterase (PDE) Cardiovascular Disease
    Aildenafil (Methisosildenafil) is a PDE-5 inhibitor that can induce vasodilation by increasing NO levels .
    Aildenafil
  • HY-118570
    5-Oxoprolyltryptophan

    		Biochemical Assay Reagents Neurological Disease
    5-Oxoprolyltryptophan is a model substrate for investigating the increase of serotonin at the cerebral level .
    5-Oxoprolyltryptophan
  • HY-121122
    A778317

    		TRP Channel Others
    A778317 is a TRPV1 antagonists. A778317 can block changes in intracellular calcium levels mediated by TRPV1 receptors, with a pIC50 value of 8.31. A-778317 can also block the activation of natural rat TRPV1 receptors in dorsal root ganglion neurons by capsaicin and acid .
    A778317
  • HY-122083
    T2384

    		PPAR Metabolic Disease
    T2384 is a peroxisome proliferator-activated receptor γ (PPARγ) ligand. T2384 also is an orally active antidiabetic agent. T2384 reduces the fasting plasma glucose levels and plasma insulin levels .
    T2384
  • HY-116150
    Xymedon

    		Others Cardiovascular Disease
    Xymedon is a pyrimidine derivative with anti-atherosclerotic effects. Xymedon reducts plasma cholesterol levels and cholesterol esterification in blood vascular cells .
    Xymedon
  • HY-148617
    ALDH2 modulator 1

    		Aldehyde Dehydrogenase (ALDH) Metabolic Disease
    ALDH2 modulator 1 is a potent and orally active aldehyde dehydrogenase-2 (ALDH2) modulator. ALDH2 modulator 1 reduces blood alcohol levels in mice .
    ALDH2 modulator 1
  • HY-123171
    ASP8497

    		Dipeptidyl Peptidase Metabolic Disease
    ASP8497 is a competitive dipeptidyl peptidase IV (DPP-IV) inhibitor that reduces blood glucose levels and increases plasma active GLP-1 and insulin levels without causing hypoglycemia in fasted normal mice. ASP8497 can be utilized for antihyperglycemic research .
    ASP8497
  • HY-D1616
    5-Bromo-5'-methyl BAPTA tetramethyl ester

    		Fluorescent Dye Others
    5-Bromo-5'-methyl BAPTA tetramethyl ester is a derivative of BAPTA, which is a calcium indicator suitable for measurement of relatively high level of calcium .
    5-Bromo-5'-methyl BAPTA tetramethyl ester
  • HY-D1713
    CM-H2DCFDA
    5 Publications Verification

    		 Reactive Oxygen Species (ROS) Others
    CM-H2DCFDA is a derivative of H2DCFDA (HY-D0940). CM-H2DCFDA can be used to determine cellular oxidant levels (Ex/Em: 495/530 nm). CM-H2DCFDA is light-sensitive .
    CM-H2DCFDA
  • HY-P2273
    Calcitonin (human)

    		CGRP Receptor Metabolic Disease
    Calcitonin (human) is a hypocalcemic hormone. Calcitonin can lower blood calcium levels and inhibit bone resorption. Calcitonin can be used in hypercalcemia or osteoporosis research .
    Calcitonin (human)
  • HY-158161
    SLC6A19-IN-1

    		Amino acid Transporter Metabolic Disease
    SLC6A19-IN-1 (Compound 16) is a SLC6A19 inhibitor. SLC6A19-IN-1 can be used to study diseases with abnormal amino acid levels, such as phenylketonuria (PKU) .
    SLC6A19-IN-1
  • HY-N0857
    Deoxyandrographolide
    1 Publications Verification

    		 Interleukin Related Neurological Disease Inflammation/Immunology
    Deoxyandrographolide suppresses LPS induced increase in mRNA levels of iNOS as well as production of proinflammatory mediators TNF-α and IL-6. Deoxyandrographolide potentiates NGF-induced neurite outgrowth .
    Deoxyandrographolide
  • HY-113646
    Shield-2

    		FKBP Others
    Shield-2 is an efficient stabilizing ligand binding to the FKBP (F36V) protein with a dissociation constant of 29 nM. Shield-2 binds tightly to the FKBP mutants destabilizing domains and prevents degradation, thus providing small molecule regulation over intracellular protein levels .
    Shield-2
  • HY-161429
    Antidiabetic agent 5

    		Amylases Glycosidase Metabolic Disease
    Antidiabetic agent 5 (compound S1) is a antidiabetic agent. Antidiabetic agent 5 inhibits the activity of α-glucosidase and α-amylase with IC50 values of 3.91，8.89 μM，respectively. Antidiabetic agent 5 decreases sugar levels. Antidiabetic agent 5 has the potential for the research of type-II diabetes .
    Antidiabetic agent 5
  • HY-108618
    BC11-38
    2 Publications Verification

    		 Phosphodiesterase (PDE) Endocrinology
    BC11-38 is a potent, selective, and biologically active PDE11 inhibitor, with IC50s of 0.28 µM and >100 µM for PDE11 and PDE1-10, respectively. BC11-38 elevates cAMP levels, PKA-mediated ATF-1 phosphorylation, and cortisol production in H295R cells .
    BC11-38
  • HY-108288
    Sulbactam pivoxil

    CP 47904

    		 Beta-lactamase Antibiotic Bacterial Infection
    Sulbactam pivoxil is a proagent of sulbactam. Sulbactam is a β-lactamase inhibitor which poorly adsorbed from gastrointestinal tract. Sulbactam pivoxil has a better absorption than the parent agent and provides high serum levels after oral administration .
    Sulbactam pivoxil
  • HY-172602
    ROS inducer 9

    		Antibiotic Bacterial Reactive Oxygen Species (ROS) Infection
    ROS inducer 9 (compound 4e) is an antibacterial agent with a MIC value of 0.25 μg/mL against E. coli. ROS inducer 9 kills bacteria by inhibiting GSH activity and increasing ROS levels. ROS inducer 9 shows low toxicity to erythrocytes and RAW 264.7 cells .
    ROS inducer 9
  • HY-110173
    TC-G 1005

    		G protein-coupled Bile Acid Receptor 1 Metabolic Disease
    TC-G 1005 is a potent, selective and orally active agonist of the BA receptor Takeda G protein-coupled receptor 5 (TGR5), with EC50s of 0.72 and 6.2 nM for hTGR5 and mTGR5, respectively. TC-G 1005 can reduce glucose levels in vivo .
    TC-G 1005
  • HY-N0686
    Pseudoprotodioscin
    1 Publications Verification

    		 Fatty Acid Synthase (FASN) MicroRNA Metabolic Disease
    Pseudoprotodioscin, a furostanoside, inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides .
    Pseudoprotodioscin
  • HY-164369
    Antibiofilm agent-10

    		Bacterial Infection
    Antibiofilm agent-10 is an antibiofilm agent, which reduces bacterial levels and improves wound healing in recalcitrant pressure ulcers (PUs) in combination with negative pressure wound therapy (NPWT). Antibiofilm agent-10 enhances pathogen killing efficacy of antimicrobials .
    Antibiofilm agent-10
  • HY-120765
    BRD2879

    		Isocitrate Dehydrogenase (IDH) Cancer
    BRD2879 is a potent IDH1-R132H inhibitor with IC50 values of 0.05, 2.5, >20, >20 µM for IDH1-R132H, IDH1-R132C, IDH1-WT, IDH2-R140Q, respectively. BRD2879 reduces (R)-2-hydroxyglutarate (R-2HG) levels .
    BRD2879
  • HY-108288R
    Sulbactam pivoxil (Standard)

    CP 47904 (Standard)

    		 Beta-lactamase Reference Standards Antibiotic Bacterial Infection
    Sulbactam pivoxil (Standard) is the analytical standard of Sulbactam pivoxil. This product is intended for research and analytical applications. Sulbactam pivoxil is a proagent of sulbactam. Sulbactam is a β-lactamase inhibitor which poorly adsorbed from gastrointestinal tract. Sulbactam pivoxil has a better absorption than the parent agent and provides high serum levels after oral administration[1].
    Sulbactam pivoxil (Standard)
  • HY-106110
    OP-2507

    		Prostaglandin Receptor Metabolic Disease
    OP-2507 is a prostacyclin analog. OP-2507 can increase brain glucose levels in mice, suppress the breakdown of energy metabolism under hypoxic conditions, and has a protective effect against changes in cyclic nucleotides in hypoxic brain tissue (specifically, an increase in cyclic AMP and a decrease in cyclic GMP). OP-2507 provides protective effects against brain hypoxia and edema .
    OP-2507
  • HY-N0686R
    Pseudoprotodioscin (Standard)

    		Reference Standards Fatty Acid Synthase (FASN) MicroRNA Metabolic Disease
    Pseudoprotodioscin (Standard) is the analytical standard of Pseudoprotodioscin. This product is intended for research and analytical applications. Pseudoprotodioscin, a furostanoside, inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides .
    Pseudoprotodioscin (Standard)
  • HY-162319
    Tubulin/HDAC-IN-4

    		Apoptosis HDAC Microtubule/Tubulin Reactive Oxygen Species (ROS) Cancer
    Tubulin/HDAC-IN-4 (compound 9n) is a dual Tubulin and HDAC inhibitor with IC50 values of 0.73, 0.43, 0.62, 2.34 µM for HDAC1, HDAC2, HDAC6, HDAC7, respectively. Tubulin/HDAC-IN-4 inhibits the tubulin polymerization by targeting the colchicine binding site. Tubulin/HDAC-IN-4 induces apoptosis and cell cycle arrest at G2/M phase. Tubulin/HDAC-IN-4 induces a significant elevation of intracellular ROS levels. Tubulin/HDAC-IN-4 shows anti-angiogenesis activity and anticancer activity .
    Tubulin/HDAC-IN-4
  • HY-172158
    ALKBH5-IN-5

    		Anaplastic lymphoma kinase (ALK) Cancer
    ALKBH5-IN-5 (compound 18l) is an ALKBH5 inhibitor, exhibiting highly selective inhibitory effect on ALKBH5 with an IC50 of 0.62 μM. ALKBH5-IN-5 exerts a strong antiproliferative effect on NB4 cells with an IC50 of 0.63 μM. ALKBH5-IN-5 binds with ALKBH5 with a Kd of 804 nM. ALKBH5-IN-5 directly targets ALKBH5 in cells and alters m 6A levels on mRNA, blocks the related downstream signal pathways, promotes differentiation, and induces Apoptosis. ALKBH5-IN-5 exerts excellent in vivo antitumor activity with TGITV values of 66.3% .
    ALKBH5-IN-5
  • HY-163654
    Ferroptosis-IN-8

    		Ferroptosis Cancer
    Ferroptosis-IN-8 is a potent ferroptosis inhibitor with an EC50 of 40.49 nM. Ferroptosis-IN-8 effectively reduces lipid ROS levels in cells. Ferroptosis-IN-8 act as an antioxidant by capturing lipid radicals, leading to a reduction in the accumulation of harmful lipid peroxides and, ultimately, inhibiting ferroptosis .
    Ferroptosis-IN-8
  • HY-169004
    CBT-295

    		TGF-beta/Smad Interleukin Related Neurological Disease Inflammation/Immunology
    CBT-295 is an orally active autotaxin (ATX) inhibitor. CBT-295 exhibits a significant reduction in inflammatory cytokines like TGF-β, TNF-α and IL-6 levels, also reduced bile duct proliferation marker CK-19 and lowered liver fibrosis. The reversal of liver fibrosis with CBT-295 led to a reduction in blood and brain ammonia levels. CBT-295 also reduced neuroinflammation induced by ammonia. CBT-295 is promising for research of liver cirrhosis and associated encephalopathy .
    CBT-295
  • HY-109556
    Insulin Detemir

    		Akt ERK Metabolic Disease
    Insulin Detemir is an artificial insulin, shows effect on controlling blood sugar levels. Insulin Detemir stimulates GLP-1 secretion as a consequence of enhanced Gcg expression by a mechanism involving activation of Akt- and/or extracellular signal-regulated kinase (ERK)-dependent-cat and CREB signaling pathways. Insulin Detemir can be used for type 2 diabetes research .
    Insulin Detemir
  • HY-163530
    GPR41 modulator 1

    		Free Fatty Acid Receptor Metabolic Disease Inflammation/Immunology
    GPR41 modulator 1 (compound 10ak) is a potent GPR41 modulator with an EC50 value of 0.679 µM. GPR41 modulator 1 shows agonistic modulator activity .
    GPR41 modulator 1
  • HY-120553
    B-355252

    		Apoptosis Neurological Disease
    B355252, a phenoxy thiophene sulfonamide small molecule, is a potent NGF receptor agonist. B355252 potentiates NGF-induced neurite outgrowth. B355252 protects ischemic neurons from neuronal loss by attenuating DNA damage, reducing ROS production and the LDH level, and preventing neuronal apoptosis. B355252 has anti-apoptotic effects in glutamate-induced excitotoxicity, as well as in a murine hippocampal cell line (HT22) model of Parkinson disease (PD) .
    B-355252
  • HY-162927
    p53-MDM2-IN-6

    		MDM-2/p53 Apoptosis Cancer
    p53-MDM2-IN-6 (Compound 10a), a LSM-83177 hydrazone analog, is a potent p53-MDM2 inhibitor with an IC50 value of 11.08 µg/mL. p53-MDM2-IN-6 arrests the cell cycle in the S phase and induces early and late Apoptosis with antiproliferative activity against HT29 cell lines with an IC50 value of 10.44 µg/mL. p53-MDM2-IN-6 inhibits p53-MDM2 interaction with increment in p-53 level and decrease the expression of GST enzymes. p53-MDM2-IN-6 is promising for research of colorectal cancer .
    p53-MDM2-IN-6
  • HY-D2377
    F8

    		Fluorescent Dye Others
    F8 is a small molecule GPR84 fluorescent probe that can visualize and detect GPR84 protein levels at the cellular and tissue levels .
    F8
  • HY-167654
    Treloxinate

    		Others Cardiovascular Disease
    Treloxinate is an effective hypolipidemic agent. Treloxinate affects only triglyceride levels in Sprague-Dawley rats, but affects both triglyceride and cholesterol levels in Wistar rats .
    Treloxinate
  • HY-151094
    FTEAA

    		Monoamine Oxidase Neurological Disease
    FTEAA is a 4-styrylpiperidine inhibitor. FTEAA exhibits potent inhibitory effect towards both monoamine oxidase with IC50s of 0.52 μM (MAO-A), 1.02 μM (MAO-B), respectively. MAO inhibitors can be used for cardiovascular, neurological and oncological disorders research .
    FTEAA
  • HY-B2243D
    Anhydrous sodium dihydrogen phosphate, for cell culture
    1 Publications Verification

    Sodium phosphate monobasic, for cell culture; Monosodium dihydrogen orthophosphate, for cell culture; Monosodium phosphate, for cell culture

    		 Biochemical Assay Reagents Others
    Anhydrous sodium dihydrogen phosphate, for cell culture is an inorganic salt compound that can be used as a buffer and nutritional supplement. Anhydrous sodium dihydrogen phosphate, for cell culture can be used in cell culture .
    Anhydrous sodium dihydrogen phosphate, for cell culture
  • HY-N8196
    Isorhamnetin 3,7-di-O-β-D-glucopyranoside

    Isorhamnetin-3,7-diglucoside; Isorhamnetin diglucoside

    		 Mitochondrial Metabolism Metabolic Disease
    Isorhamnetin 3,7-di-O-β-D-glucopyranoside, a major flavonoid compound, is metabolized in vivo by intestinal bacteria to isorhamnetin and that isorhamnetin plays an important role as an antioxidant .
    Isorhamnetin 3,7-di-O-β-D-glucopyranoside
  • HY-B2243BR
    Anhydrous sodium dihydrogen phosphate, for molecular biology (Standard)

    Sodium phosphate monobasic for molecular biology (Standard); Monosodium dihydrogen orthophosphate for molecular biology (Standard); Monosodium phosphate for molecular biology (Standard)

    		 Biochemical Assay Reagents Reference Standards Others
    Anhydrous sodium dihydrogen phosphate, for molecular biology (Standard) is the analytical standard of Anhydrous sodium dihydrogen phosphate, for molecular biology. This product is intended for research and analytical applications. Anhydrous sodium dihydrogen phosphate, for molecular biology is an inorganic salt compound that can be used as a buffer and nutritional supplement. Anhydrous sodium dihydrogen phosphate, for molecular biology can be used in molecular biology experiments .
    Anhydrous sodium dihydrogen phosphate, for molecular biology (Standard)
  • HY-14899
    Taprenepag
    4 Publications Verification

    CP-544326

    		 Prostaglandin Receptor Endocrinology
    Taprenepag (CP-544326) is a potent and selective prostaglandin EP(2) agonist with IC50s of 10 and 15 nM for human and rat EP2, respectively. Taprenepag shows selectivity for EP2 over other EP receptors (IC50s>3200 nM for EP1, EP3, and EP4) and a panel of 37 G protein-coupled receptors .
    Taprenepag
  • HY-157561
    K2-B4-3e

    		PROTACs Epigenetic Reader Domain Cancer
    K2-B4-3e is a potent BRD4 PROTAC. K2-B4-3e induces BRD4 degradation with a DC50 value of 66 nM .
    K2-B4-3e
  • HY-B2243B
    Anhydrous sodium dihydrogen phosphate, for molecular biology
    1 Publications Verification

    Sodium phosphate monobasic for molecular biology; Monosodium dihydrogen orthophosphate for molecular biology; Monosodium phosphate for molecular biology

    		 Biochemical Assay Reagents Others
    Anhydrous sodium dihydrogen phosphate, for molecular biology is an inorganic salt compound that can be used as a buffer and nutritional supplement. Anhydrous sodium dihydrogen phosphate, for molecular biology can be used in molecular biology experiments .
    Anhydrous sodium dihydrogen phosphate, for molecular biology
  • HY-19061
    CGP 28014

    		COMT Neurological Disease
    CGP 28014 is a catechol-O-methyltransferase inhibitor. CGP 28014 can lower HVA levels and increase DOPAC levels in the striatum of rats, making it useful for research on Parkinson's disease .
    CGP 28014
  • HY-118113
    BVT-116429

    		11β-HSD Others
    BVT-116429 is an 11βHSD1 inhibitor with the activity of increasing adiponectin concentration and improving glucose homeostasis in diabetic mice. BVT-116429 can increase plasma adiponectin levels in diabetic KKAy mice, reduce basal insulin levels, and reduce fasting blood glucose levels after 10 days of inhibition, similar to the effect of rosiglitazone.
    BVT-116429
  • HY-N1967
    Dihydrocurcumin

    		Fatty Acid Synthase (FASN) Metabolic Disease
    Dihydrocurcumin, a major metabolites of curcumin, reduces lipid accumulation and oxidative stress. Dihydrocurcumin regulates mRNA and protein expression levels of SREBP-1C, PNPLA3 and PPARα, increases protein expression levels of pAKT and PI3K, and reduced the levels of cellular NO and ROS via Nrf2 signaling pathways .
    Dihydrocurcumin
  • HY-23119
    Sodium thiocyanate, GR, 99%

    Thiocyanate sodium

    		 Interleukin Related Reactive Oxygen Species (ROS) Inflammation/Immunology
    Sodium thiocyanate reduces plasma levels of the pro-inflammatory cytokine IL-6, and increases the anti-inflammatory cytokine IL-10 levels. Sodium thiocyanate also significantly reduces of ROS formation .
    Sodium thiocyanate, GR, 99%
  • HY-N8063
    γ-Glutamylornithine

    		Endogenous Metabolite Others
    γ-Glutamylornithine is the urine excreta of patients with HHH syndrome (hyperuricemia, hyperaminemia, and hypercitrullinuria) and rotary atrophy associated with hyperuricemia. Increased levels of endogenous ornithine increase levels of γ-Glutamylornithine in the urine .
    γ-Glutamylornithine
  • HY-N15293
    Sesamolinol

    		Others Metabolic Disease
    Sesamolinol is a lignin. Sesamolinol is found in sesame seeds. Sesame seed lignans are considered responsible for a number of beneficial health effects including lowering of plasma cholesterol levels and elevation of γ-tocopherol levels .
    Sesamolinol
  • HY-115449
    Chromeceptin
    1 Publications Verification

    94G6

    		 IGF-1R Akt mTOR Cancer
    Chromeceptin (94G6) is an IGF signaling pathway inhibitor. Chromeceptin suppresses IGF2 expression at mRNA and protein levels in hepatocyte and HCC cells. Chromeceptin inhibits the phosphorylation levels of AKT and mTOR .
    Chromeceptin

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