2. Metabolic Enzyme/Protease
  3. ATP Citrate Lyase
  4. EVT0185

EVT0185 is an orally active ATP citrate lyase (ACLY) inhibitor. EVT0185 is converted to a CoA thioester in the liver by SLC27A2 and interacts with the CoA-binding site of ACLY. EVT0185-CoA inhibits ACLY activity with an IC50 of 2.5 μM. EVT0185 can phenocopy the immune and antitumour effects of genetic ACLY deletion. EVT0185 can increases tumour-infiltrating B cells and chemokine CXCL13 levels. EVT0185 can be used for the research of cancer, such as hepatocellular carcinoma (HCC).

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EVT0185

EVT0185 Chemical Structure

CAS No. : 2588489-03-4

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EVT0185 Related Antibodies

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Description

EVT0185 is an orally active ATP citrate lyase (ACLY) inhibitor. EVT0185 is converted to a CoA thioester in the liver by SLC27A2 and interacts with the CoA-binding site of ACLY. EVT0185-CoA inhibits ACLY activity with an IC50 of 2.5 μM. EVT0185 can phenocopy the immune and antitumour effects of genetic ACLY deletion. EVT0185 can increases tumour-infiltrating B cells and chemokine CXCL13 levels. EVT0185 can be used for the research of cancer, such as hepatocellular carcinoma (HCC)[1].

In Vitro

EVT0185 inhibits lipogenesis with an IC50 of 0.46 μM in hepatocytes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

EVT0185 Related Antibodies
In Vivo

EVT0185 (30-100 mg/kg, i.g., for 1 month) reduces tumour burden in MASH-HCC mice models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Metabolic dysfunction-associated steatohepatitis (MASH)-driven hepatocellular carcinoma (HCC) mice models[1]
Dosage: 30 and 100 mg/kg
Administration: Orally gavaged, 1 month
Result: Reduced tumor numbers in liver.
Reduced tumour surface area and lipid accumulation.
Elevated levels of AFP.
Increased B cells and B cell chemoattractant CXCL13 levels.
Increased cleaved caspase 3 levels and reduced Ki67 levels.
Molecular Weight

362.50

Formula

C22H34O4
CAS No.
SMILES

O=C(O)C(C)(C)CCCCC1=CC=C(CCCCC(C)(C(O)=O)C)C=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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EVT0185 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EVT01852588489-03-4EVT 0185EVT-0185ATP Citrate LyaseACLYHCCAFPB cellsCXCL13Inhibitorinhibitorinhibit

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