2. Metabolic Enzyme/Protease
  3. Apolipoprotein
  4. Volanesorsen sodium

Volanesorsen sodium  (Synonyms: ISIS 304801 sodium)

Cat. No.: HY-145727A Purity: 98.51%
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Volanesorsen (ISIS 304801) sodium is an antisense oligonucleotide inhibitor of apolipoprotein CIII (apo-CIII) mRNA that reduces triglyceride levels and improves insulin resistance. Volanesorsen sodium is being studied in the treatment of hypertriglyceridemia, familial chylosiderosis syndrome, and type 2 diabetes.

For research use only. We do not sell to patients.

DNA, d(P-thio)([2′-O-(2-methoxyethyl)]rA-[2′-O-(2-methoxyethyl)]rG-[2′-O-(2-methoxyethyl)]m5rC-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]m5rU-m5C-T-T-G-T-m5C-m5C-A-G-m5C-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]rA-[2′-O-(2-methoxyethyl)]m5rU), sodium salt

Volanesorsen sodium Chemical Structure

CAS No. : 1573402-50-2

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Based on 1 publication(s) in Google Scholar

Other Forms of Volanesorsen sodium:

Volanesorsen sodium Related Antibodies

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apoE apoB apoA1 apoA2 apoA4 apoC1 apoC2 apoC3

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Description

Volanesorsen (ISIS 304801) sodium is an antisense oligonucleotide inhibitor of apolipoprotein CIII (apo-CIII) mRNA that reduces triglyceride levels and improves insulin resistance. Volanesorsen sodium is being studied in the treatment of hypertriglyceridemia, familial chylosiderosis syndrome, and type 2 diabetes[1][2][3][4][5].

IC50 & Target[1]

apoC3

 

In Vivo

Volanesorsen (1.5-50 mg/kg; i.p.; once a week for 2 weeks) sodium dose-dependently reduces human apolipoprotein CIII (apo-CIII) mRNA, plasma apo-CIII protein and triglyceride (TG) levels in human apo-CIII transgenic mice[1].
Volanesorsen (4-40 mg/kg; s.c.; once a week for 13 weeks) sodium dose-responsively reduces apoC-III mRNA levels in the liver of cynomolgus monkeys[1].
Volanesorsen (10 mg/kg; s.c.; once weekly for 10 weeks) sodium reduces plasma triglyceride levels in hypertriglyceridemic rhesus monkeys[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Chow-Fed Cynomolgus[1]
Dosage: 4, 8, 12 and 40 mg/kg
Administration: Subcutaneous injection (s.c.) Once a week for 13 weeks
Result: Reduced apoC-III mRNA by 47%, 51%, 80%, and 89% in a dose-responsive manner.
Animal Model: Rhesus monkeys with hypertriglyceridemia after taking high fructose supplements[1]
Dosage: 10 mg/kg
Administration: Subcutaneous injection (s.c.) Once a week for 10 weeks
Result: Reduced plasma triglycerides, very low–density lipoprotein (VLDL)+chylomicron triglyceride, and decreased postprandial triglyceride excursion, while increasing high-density lipoprotein-cholesterol (HDL-C) in hypertriglyceridemic rhesus monkeys.
Clinical Trial
Molecular Weight

7165.00

Formula

C230H301N63Na19O125P19S19
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Volanesorsen (sodium)]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: 98.51%

SDS (252 KB)

COA (245 KB) LCMS (300 KB)

Handling Instructions (2659 KB)
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Volanesorsen sodium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Volanesorsen1573402-50-2ISIS 304801ISIS304801ISIS-304801Apolipoproteinapo-CIIImRNAhypertriglyceridemiafamilial chylosiderosis syndrometype 2 diabetesInhibitorinhibitorinhibit

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