2. Membrane Transporter/Ion Channel Neuronal Signaling GPCR/G Protein Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. GABA Receptor 5-HT Receptor Reactive Oxygen Species (ROS)
  4. Aminochalcone 4AAF

Aminochalcone 4AAF is a neuroprotective agent that exerts anxiolytic effects through GABAA and 5-HT receptors. Aminochalcone 4AAF has high selectivity for 5-HT3A and 5-HT2C receptors, and stimulates allosteric behavior toward the 5-HT2A receptor. Aminochalcone 4AAF shows hypoglycemic effects and reduces the level of ROS in the liver. Aminochalcone 4AAF delays the clonic stage of the epileptic seizures . Aminochalcone 4AAF can be used in the study of anxiety, hyperglycemia, and seizures.

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Aminochalcone 4AAF

Aminochalcone 4AAF Chemical Structure

CAS No. : 38239-51-9

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Aminochalcone 4AAF Related Antibodies

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Description

Aminochalcone 4AAF is a neuroprotective agent that exerts anxiolytic effects through GABAA and 5-HT receptors. Aminochalcone 4AAF has high selectivity for 5-HT3A and 5-HT2C receptors, and stimulates allosteric behavior toward the 5-HT2A receptor. Aminochalcone 4AAF shows hypoglycemic effects and reduces the level of ROS in the liver. Aminochalcone 4AAF delays the clonic stage of the epileptic seizures . Aminochalcone 4AAF can be used in the study of anxiety, hyperglycemia, and seizures[1].

In Vivo

Aminochalcone 4AAF (20 uL of 0.1-10 mg/mL, p.o., single dose) shows anxiolytic and hypoglycemic effects, reversing sucrose-induced anxiety and hyperglycemia in adult zebrafish and delaying the clonic stage of the epileptic crisis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult zebrafish aged between 90 and 120 days, measuring approximately 3.5 cm in length and weighing approximately 0.4 g[1]
Dosage: 20 uL of 0.1, 0.5, or 10 mg/mL
Administration: p.o. for a single dose
Result: Showed not toxicity to adult zebrafish (LC50 > 1.0 mg/mL).
Exhibited anxiolytic behavior in novel tank test.
Caused a significant impairment of motor function in open field test and spinning task.
Altered the latency time and the number of crossings between the light and dark sides.
Restored the locomotor pattern when pretreated with Flumazenil (HY-B0009) (0.1 mg/mL).
Reduced the time the fish spent in the light area of the aquarium when pretreated with Cyproheptadine (HY-B1622), Pizotifen (HY-B0115), and Granisetron (HY-B0071).
Increased latency time and reduced the number of crossings from the light to the dark.
Prevented hyperglycemia-induced oxidative stress in liver and brain tissues of adult zebrafish (0.5 mg/mL).
Reversed PTZ-induced convulsive behavior in stage three (1.0 mg/mL).
Molecular Weight

223.27

Formula

C15H13NO
CAS No.
SMILES

NC1=CC=C(C=C1)C(/C=C/C2=CC=CC=C2)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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Aminochalcone 4AAF Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aminochalcone 4AAF38239-51-9GABA Receptor5-HT ReceptorReactive Oxygen Species (ROS)Gamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorSerotonin Receptor5-hydroxytryptamine ReceptoranxietyhyperglycemiaseizuresInhibitorinhibitorinhibit

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