2. Membrane Transporter/Ion Channel Neuronal Signaling GPCR/G Protein Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. GABA Receptor 5-HT Receptor Reactive Oxygen Species (ROS)
  4. Aminochalcone 4AAF

Aminochalcone 4AAF is a neuroprotective agent that exerts anxiolytic effects through GABAA and 5-HT receptors. Aminochalcone 4AAF has high selectivity for 5-HT3A and 5-HT2C receptors, and stimulates allosteric behavior toward the 5-HT2A receptor. Aminochalcone 4AAF shows hypoglycemic effects and reduces the level of ROS in the liver. Aminochalcone 4AAF delays the clonic stage of the epileptic seizures . Aminochalcone 4AAF can be used in the study of anxiety, hyperglycemia, and seizures.

For research use only. We do not sell to patients.

Aminochalcone 4AAF

Aminochalcone 4AAF Chemical Structure

CAS No. : 38239-51-9

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Aminochalcone 4AAF Related Antibodies

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Description

Aminochalcone 4AAF is a neuroprotective agent that exerts anxiolytic effects through GABAA and 5-HT receptors. Aminochalcone 4AAF has high selectivity for 5-HT3A and 5-HT2C receptors, and stimulates allosteric behavior toward the 5-HT2A receptor. Aminochalcone 4AAF shows hypoglycemic effects and reduces the level of ROS in the liver. Aminochalcone 4AAF delays the clonic stage of the epileptic seizures . Aminochalcone 4AAF can be used in the study of anxiety, hyperglycemia, and seizures[1].

Cellular Effect
Cell Line Type Value Description References
CCRF-CEM IC50
8.5 μM
Compound: 8a
Antiproliferative activity against human CEM cells after 48 hrs by Coulter counting analysis
Antiproliferative activity against human CEM cells after 48 hrs by Coulter counting analysis
[PMID: 19250822]
DLD-1 EC50
33 μM
Compound: 14
Cytotoxicity against human DLD-1 cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay
Cytotoxicity against human DLD-1 cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay
[PMID: 36356534]
FHC CC50
> 100 μM
Compound: 14
Cytotoxicity against human FHC cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay
Cytotoxicity against human FHC cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay
[PMID: 36356534]
FM3A IC50
34 μM
Compound: 8a
Antiproliferative activity against mouse FM3A cells after 48 hrs by Coulter counting analysis
Antiproliferative activity against mouse FM3A cells after 48 hrs by Coulter counting analysis
[PMID: 19250822]
HCT-116 EC50
23 μM
Compound: 14
Cytotoxicity against p53-/- human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay
Cytotoxicity against p53-/- human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay
[PMID: 36356534]
HCT-116 EC50
27 μM
Compound: 14
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay
[PMID: 36356534]
HCT-116 IC50
14.1 μM
Compound: 1
Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
10.1039/C4MD00371C
HL-60 IC50
6.4 μM
Compound: 1
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
10.1039/C4MD00371C
HT-29 EC50
35 μM
Compound: 14
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability incubated for 48 hrs by AlamarBlue-based assay
[PMID: 36356534]
HeLa IC50
7.7 μM
Compound: 8a
Antiproliferative activity against human HeLa cells after 48 hrs by Coulter counting analysis
Antiproliferative activity against human HeLa cells after 48 hrs by Coulter counting analysis
[PMID: 19250822]
L1210 IC50
14 μM
Compound: 8a
Antiproliferative activity against mouse L1210 cells after 48 hrs by Coulter counting analysis
Antiproliferative activity against mouse L1210 cells after 48 hrs by Coulter counting analysis
[PMID: 19250822]
MOLT-4 IC50
7.9 μM
Compound: 8a
Antiproliferative activity against human MOLT4 cells after 48 hrs by Coulter counting analysis
Antiproliferative activity against human MOLT4 cells after 48 hrs by Coulter counting analysis
[PMID: 19250822]
OVCAR-8 IC50
> 22.4 μM
Compound: 1
Cytotoxicity against human OVCAR8 cells after 72 hrs by MTT assay
Cytotoxicity against human OVCAR8 cells after 72 hrs by MTT assay
10.1039/C4MD00371C
PBMC IC50
20.2 μM
Compound: 1
Cytotoxicity against human PBMC cells after 72 hrs by MTT assay
Cytotoxicity against human PBMC cells after 72 hrs by MTT assay
10.1039/C4MD00371C
SF-295 IC50
> 22.4 μM
Compound: 1
Cytotoxicity against human SF295 cells after 72 hrs by MTT assay
Cytotoxicity against human SF295 cells after 72 hrs by MTT assay
10.1039/C4MD00371C
In Vivo

Aminochalcone 4AAF (20 μL of 0.1-10 mg/mL, p.o., single dose) shows anxiolytic and hypoglycemic effects, reversing sucrose-induced anxiety and hyperglycemia in adult zebrafish and delaying the clonic stage of the epileptic crisis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult zebrafish aged between 90 and 120 days, measuring approximately 3.5 cm in length and weighing approximately 0.4 g[1]
Dosage: 20 μL of 0.1, 0.5, or 10 mg/mL
Administration: p.o. for a single dose
Result: Showed not toxicity to adult zebrafish (LC50 > 1.0 mg/mL).
Exhibited anxiolytic behavior in novel tank test.
Caused a significant impairment of motor function in open field test and spinning task.
Altered the latency time and the number of crossings between the light and dark sides.
Restored the locomotor pattern when pretreated with Flumazenil (HY-B0009) (0.1 mg/mL).
Reduced the time the fish spent in the light area of the aquarium when pretreated with Cyproheptadine (HY-B1622), Pizotifen (HY-B0115), and Granisetron (HY-B0071).
Increased latency time and reduced the number of crossings from the light to the dark.
Prevented hyperglycemia-induced oxidative stress in liver and brain tissues of adult zebrafish (0.5 mg/mL).
Reversed PTZ-induced convulsive behavior in stage three (1.0 mg/mL).
Molecular Weight

223.27

Formula

C15H13NO
CAS No.
SMILES

NC1=CC=C(C=C1)C(/C=C/C2=CC=CC=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Aminochalcone 4AAF Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aminochalcone 4AAF38239-51-9GABA Receptor5-HT ReceptorReactive Oxygen Species (ROS)Gamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorSerotonin Receptor5-hydroxytryptamine ReceptoranxietyhyperglycemiaseizuresInhibitorinhibitorinhibit

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