1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Enterostatin (rat)

Enterostatin (rat), an orally active activation peptide of procolipase, selectively reduces fat intake. Enterostatin (rat) reduces serum cholesterol levels by way of a CCK1 receptor-dependent mechanism.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Enterostatin (rat)

Enterostatin (rat) Chemical Structure

CAS No. : 117137-85-6

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Based on 1 publication(s) in Google Scholar

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Description

Enterostatin (rat), an orally active activation peptide of procolipase, selectively reduces fat intake. Enterostatin (rat) reduces serum cholesterol levels by way of a CCK1 receptor-dependent mechanism[1][2].

In Vivo

Enterostatin (rat) (50-100 mg/kg; p.o.) has a hypocholesterolemic effect mediated by CCK1 receptor in male ddY mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ddY mice[1]
Dosage: 50 and 100 mg/kg
Administration: Oral administration
Result: Reduced serum cholesterol levels after oral administration at a dose of 100 mg/kg.
Molecular Weight

582.65

Formula

C25H42N8O8

CAS No.
Appearance

Solid

Color

white

Sequence

Val-Pro-Asp-Pro-Arg

Sequence Shortening

VPDPR

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (42.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7163 mL 8.5815 mL 17.1630 mL
5 mM 0.3433 mL 1.7163 mL 3.4326 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7163 mL 8.5815 mL 17.1630 mL 42.9074 mL
5 mM 0.3433 mL 1.7163 mL 3.4326 mL 8.5815 mL
10 mM 0.1716 mL 0.8581 mL 1.7163 mL 4.2907 mL
15 mM 0.1144 mL 0.5721 mL 1.1442 mL 2.8605 mL
20 mM 0.0858 mL 0.4291 mL 0.8581 mL 2.1454 mL
25 mM 0.0687 mL 0.3433 mL 0.6865 mL 1.7163 mL
30 mM 0.0572 mL 0.2860 mL 0.5721 mL 1.4302 mL
40 mM 0.0429 mL 0.2145 mL 0.4291 mL 1.0727 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Enterostatin (rat)
Cat. No.:
HY-P3704
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