2. Metabolic Enzyme/Protease Anti-infection
  3. Endogenous Metabolite Bacterial
  4. D-Cysteine

D-Cysteine, the D-isomer of cysteine, is an orally active antibacterial agent and a regulator of neural progenitor cell proliferation. D-Cysteine can inhibit Escherichia coli, Streptococcus mutans, and Streptococcus sanguinis. The no-observed-adverse-effect level of D-Cysteine in rats should be less than 500 mg/kg/day.

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D-Cysteine Chemical Structure

D-Cysteine Chemical Structure

CAS No. : 921-01-7

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Other Forms of D-Cysteine:

D-Cysteine Related Antibodies

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Description

D-Cysteine, the D-isomer of cysteine, is an orally active antibacterial agent and a regulator of neural progenitor cell proliferation. D-Cysteine can inhibit Escherichia coli, Streptococcus mutans, and Streptococcus sanguinis. The no-observed-adverse-effect level of D-Cysteine in rats should be less than 500 mg/kg/day[1][2][3][4].

In Vitro

D-Cysteine (0-60 mM; 24 h) inhibits the growth and cariogenic virulence of dual-species biofilms formed by S. mutans and S. sanguinis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

D-Cysteine Related Antibodies
In Vivo

D-Cysteine (oral gavage; 500-2000 mg/kg; 28 days) is potentially toxic to the kidney, epididymis and stomach of rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Crl:CD(SD)IGS rats[2]
Dosage: 500, 1,000 and 2,000 mg/kg
Administration: Oral gavage (i.g.); 28 days
Result: Caused anemia and renal injuries such as basophilic tubules with eosinophilic material in the lumen, increased numbers of basophilic tubules, and crystal deposition in the medulla in the 2,000 mg/kg/day-treated group.
Caused sperm granuloma in the epididymis, necropsy findings suggestive of focal erosion in the stomach mucosa, and salivation in the 1,000 or 2,000 mg/kg/day-treated groups. One rat in the 2,000 mg/kg/day-treated group died due to renal failure.
Molecular Weight

121.16

Formula

C3H7NO2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N[C@H](CS)C(O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 4 mg/mL (33.01 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 8.2535 mL 41.2674 mL 82.5348 mL
5 mM 1.6507 mL 8.2535 mL 16.5070 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Purity & Documentation

Purity: ≥98.0%

SDS (392 KB)

COA (245 KB) HNMR (110 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 8.2535 mL 41.2674 mL 82.5348 mL 206.3370 mL
5 mM 1.6507 mL 8.2535 mL 16.5070 mL 41.2674 mL
10 mM 0.8253 mL 4.1267 mL 8.2535 mL 20.6337 mL
15 mM 0.5502 mL 2.7512 mL 5.5023 mL 13.7558 mL
20 mM 0.4127 mL 2.0634 mL 4.1267 mL 10.3169 mL
25 mM 0.3301 mL 1.6507 mL 3.3014 mL 8.2535 mL
30 mM 0.2751 mL 1.3756 mL 2.7512 mL 6.8779 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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D-Cysteine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

D-Cysteine921-01-7Endogenous MetaboliteBacterialEscherichia coliStreptococcus mutansStreptococcus sanguinisInhibitorinhibitorinhibit

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