2. Immunology/Inflammation
  3. NO Synthase
  4. AVE-9488

AVE-9488 is an eNOS enhancer with the activity of protecting the heart from ischemia-reperfusion injury. AVE-9488 can upregulate eNOS expression, increase NO production, reduce myocardial ischemia-reperfusion injury, and reduce the level of reactive oxygen species.

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AVE-9488

AVE-9488 Chemical Structure

CAS No. : 291756-32-6

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Based on 1 publication(s) in Google Scholar

AVE-9488 Related Antibodies

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nNOS iNOS eNOS

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Description

AVE-9488 is an eNOS enhancer with the activity of protecting the heart from ischemia-reperfusion injury. AVE-9488 can upregulate eNOS expression, increase NO production, reduce myocardial ischemia-reperfusion injury, and reduce the level of reactive oxygen species[1].

IC50 & Target

eNOS

 

Molecular Weight

255.29

Formula

C16H14FNO
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1CC2=C(C=CC=C2)C1)C3=CC=C(F)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (97.93 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9171 mL 19.5856 mL 39.1711 mL
5 mM 0.7834 mL 3.9171 mL 7.8342 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.9171 mL 19.5856 mL 39.1711 mL 97.9278 mL
5 mM 0.7834 mL 3.9171 mL 7.8342 mL 19.5856 mL
10 mM 0.3917 mL 1.9586 mL 3.9171 mL 9.7928 mL
15 mM 0.2611 mL 1.3057 mL 2.6114 mL 6.5285 mL
20 mM 0.1959 mL 0.9793 mL 1.9586 mL 4.8964 mL
25 mM 0.1567 mL 0.7834 mL 1.5668 mL 3.9171 mL
30 mM 0.1306 mL 0.6529 mL 1.3057 mL 3.2643 mL
40 mM 0.0979 mL 0.4896 mL 0.9793 mL 2.4482 mL
50 mM 0.0783 mL 0.3917 mL 0.7834 mL 1.9586 mL
60 mM 0.0653 mL 0.3264 mL 0.6529 mL 1.6321 mL
80 mM 0.0490 mL 0.2448 mL 0.4896 mL 1.2241 mL
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AVE-9488 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AVE-9488291756-32-6AVE9488AVE 9488NO SynthaseNitric oxide synthasesNOSInhibitorinhibitorinhibit

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