2. Neuronal Signaling NF-κB Metabolic Enzyme/Protease Immunology/Inflammation Apoptosis
  3. Monoamine Oxidase Reactive Oxygen Species (ROS) NF-κB Bcl-2 Family Cholinesterase (ChE)
  4. TFSeB

TFSeB is a neuroprotective agent. TFSeB can reduce Streptozotocin (STZ) (HY-13753) induced MAO-B and AChE activity. TFSeB exerts neuroprotective effects by increasing the expression of BCL-2, BDNF, NRF2, and decreasing the expression of BAX. TFSeB can reduce lipid peroxidation (TBARS) and reactive oxygen species (ROS) levels. TFSeB can reduce neuroinflammation. TFSeB can be used for research on Alzheimer’s disease.

For research use only. We do not sell to patients.

TFSeB Chemical Structure

TFSeB Chemical Structure

CAS No. : 3017240-62-6

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TFSeB Related Antibodies

Top Publications Citing Use of Products

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MAO-A MAO-B

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

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AChE BChE

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Description

TFSeB is a neuroprotective agent. TFSeB can reduce Streptozotocin (STZ) (HY-13753) induced MAO-B and AChE activity. TFSeB exerts neuroprotective effects by increasing the expression of BCL-2, BDNF, NRF2, and decreasing the expression of BAX. TFSeB can reduce lipid peroxidation (TBARS) and reactive oxygen species (ROS) levels. TFSeB can reduce neuroinflammation. TFSeB can be used for research on Alzheimer’s disease[1].

IC50 & Target

Bcl-2

 

AChE

 

Bax

 

In Vivo

TFSeB (1 mg/kg or 5 mg/kg; i.g.; once daily; for 20 days) can exert neuroprotective effects, improve cognitive impairment, reduce oxidative stress and neuroinflammation, and regulate the activity of neurotransmitter related enzymes in the Male Swiss mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss mice (25-35 g) received intracerebroventricular injections of Streptozotocin (STZ) (HY-13753) (3 mg/kg)[1]
Dosage: 1 mg/kg or 5 mg/kg
Administration: Oral gavage (i.g.); once daily for 20 days
Result: Significantly improved STZ-induced spatial working memory deficits.
Restored short-term and long-term recognition memory in the mice with an Alzheimer’s disease.
Significantly reduced MAO-B activity as a MAO-B modulator.
Significantly reversed AChE activity in the STZ mice.
Improved oxidative stress levels, including a reduction in TBARS, ROS, NOx, and NPSH levels.
Upregulated the levels of BDNF, NRF2 and BCL-2 and downregulated the levels of NF-κB, IL-6, CAT, SOD, GSk3B and BAX.
Did not cause liver, kidney toxicity or metabolic abnormalities.
Molecular Weight

357.23

Formula

C16H13F3OSe
CAS No.
SMILES

FC(F)(C1=CC=CC([Se]CC2CC3=C(O2)C=CC=C3)=C1)F
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TFSeB Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TFSeB3017240-62-6Monoamine OxidaseReactive Oxygen Species (ROS)NF-κBBcl-2 FamilyCholinesterase (ChE)MAONuclear factor-κBNuclear factor-kappaBMAO-BAChEBCL-2ROSneuroinflammationInhibitorinhibitorinhibit

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