2. Metabolic Enzyme/Protease Stem Cell/Wnt
  3. Microsomal Triglyceride Transfer Protein (MTP) Smo Hedgehog
  4. LAB687

LAB687 (Compound 2a) is a Microsomal triglyceride transfer protein (MTP) inhibitor with an IC50 of 0.9  nM for the secretion of apoB from HepG2 cells. LAB687 is also a Smoothened (Smo) antagonist with IC50s of 2.48 and 3.42 μM for mouse and human Smo receptor, respectively. LAB687 can lower the level of triglycerides and LDL cholesterol and inhibits the Hedgehog signaling pathway.

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LAB687

LAB687 Chemical Structure

CAS No. : 256397-11-2

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Description

LAB687 (Compound 2a) is a Microsomal triglyceride transfer protein (MTP) inhibitor with an IC50 of 0.9  nM for the secretion of apoB from HepG2 cells. LAB687 is also a Smoothened (Smo) antagonist with IC50s of 2.48 and 3.42 μM for mouse and human Smo receptor, respectively. LAB687 can lower the level of triglycerides and LDL cholesterol and inhibits the Hedgehog signaling pathway[1].

Molecular Weight

468.47

Formula

C26H23F3N2O3
CAS No.
SMILES

COC(N[C@@H]1CC2=CC=C(C=C2C1)NC(C(C=CC=C3C)=C3C4=CC=C(C(F)(F)F)C=C4)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LAB687 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LAB687256397-11-2LAB 687LAB-687Microsomal Triglyceride Transfer Protein (MTP)SmoHedgehogSmoothenedInhibitorMicrosomal triglyceride transfer proteinMTPAntagonistapoBHedgehog signaling pathwayHepG2 cellsinhibitorinhibit

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