3′-Oxolutein  (Synonyms: 3'-Dehydrolutein; Philosamiaxanthin)

3′-Oxolutein, a metabolite of dietary lutein, is an anti-inflammatory agent and antioxidant, 3′-Oxolutein mitigates the effects of glutamate-induced ROS production and proinflammatory cytokine secretions in SH-SY5Y cells. 3'-Oxolutein reduces glutamate-induced iron content and increases thiol levels. 3′-Oxolutein can be used for the study of inflammation^[1].

3'-Oxolutein (10 ng/μL, 10-30 min) significantly reduces glutamate-induced ROS production in SH-SY5Y cells^[1].
3'-Oxolutein (10 ng/μL, 24-72 h) increases small molecule antioxidants level at 48 h but fails to modify TAC levels in glutamate-treated SH-SY5Y cells^[1].
3'-Oxolutein (10 ng/μL, 24-72 h) alone does not alter SOD activity and cannot inhibit the decrease in SOD in glutamate-treated SH-SY5Y cells^[1].
3'-Oxolutein (10 ng/μL, 24-72 h) reduces glutamate-induced iron content in SH-SY5Y cells^[1].
3'-Oxolutein (10 ng/μL, 24-72 h) reduces glutamate-induced relative mRNA expressions of ALOX5, ALOX15, and ACSL4 genes in SH-SY5Y cells^[1].
3'-Oxolutein (10 ng/μL, 24-72 h) significantly increases thiol levels after 48 and 72 h ^[1].
3'-Oxolutein (10 ng/μL, 24-72 h) does not induce alteration in IL-6 secretion in SH-SY5Y cells but reduces glutamate-induced IL-8 secretions and diminishes TNFα levels^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

566.86

C₄₀H₅₄O₂

23984-55-6

CC1(C)C(/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/[C@@H]2C(C)(CC(C=C2C)=O)C)=C(C)C[C@@H](O)C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Pap R, et al. Protective Effects of 3'-Epilutein and 3'-Oxolutein against Glutamate-Induced Neuronal Damage. Int J Mol Sci. 2023 Jul 26;24(15):12008.