2. Neuronal Signaling Stem Cell/Wnt Immunology/Inflammation NF-κB Protein Tyrosine Kinase/RTK
  3. Notch Interleukin Related NF-κB VEGFR FGFR NO Synthase
  4. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2)

Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) 

Cat. No.: HY-P990252
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Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) is an anti-mouse Delta-like protein 4/DLL4 IgG monoclonal antibody. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) can reduce angiogenesis and density by blocking the DLL4-Notch signaling pathway. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) reduces inflammatory response by decreasing NF-κB activity and pro-inflammatory factors (IL-1β, iNOS, IL-6) levels. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) can inhibit Th17 cell differentiation and IL-17A production. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) can reduce macrophage infiltration and alleviate insulin resistance. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) can be used for researches on inflammation, metabolic conditions and cancer such as atherosclerosis, pancreatic cancer and asthma.

For research use only. We do not sell to patients.

Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2)

Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) Chemical Structure

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Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) Related Antibodies

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Description

Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) is an anti-mouse Delta-like protein 4/DLL4 IgG monoclonal antibody. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) can reduce angiogenesis and density by blocking the DLL4-Notch signaling pathway. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) reduces inflammatory response by decreasing NF-κB activity and pro-inflammatory factors (IL-1β, iNOS, IL-6) levels. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) can inhibit Th17 cell differentiation and IL-17A production. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) can reduce macrophage infiltration and alleviate insulin resistance. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) can be used for researches on inflammation, metabolic conditions and cancer such as atherosclerosis, pancreatic cancer and asthma[1][2][3][4].

Isotype

Armenian hamster IgG
Recommend Isotype Controls
Species Reactivity

Mouse
IC50 & Target[1][3][4]

NF-κB

 

iNOS

 

FGFR1

 

IL-6

 

IL-1β

 

IL-17A

 

In Vivo

Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) (12.5 µg/kg, i.p., once every 2 days or every 3 days, for 15 days) changes the vascular structure of the bone marrow and promotes myeloid differentiation in Balb/c mice with a sub-lethally irradiation[1].
Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) (250 μg, i.p., twice a week, for 5 weeks) significantly inhibits tumor growth in male SCID mice bearing PK-1 tumors[2].
Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) (250 μg, i.p., twice a week, for 12 weeks) significantly improves atherosclerosis, insulin resistance, obesity and other metabolic abnormalities in Ldlr-/- mice and Lepob/Lepob mice with a high fat and high cholesterol diet[3].
Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) (250 μg, i.p., on day 15, 18 and 21) improves airway inflammation and asthma symptoms in female BALB/c mice with a toluene diisocyanate (TDI) induced asthma model[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/c mice with a sub-lethally irradiation (6-8 weeks)[1]
Dosage: 12.5 µg/kg
Administration: Intraperitoneal injection (i.p.), once every 2 days or every 3 days, for 15 days
Result: Increased CD31+, VE Cadherin+ and c-kit+ vascular density.
Increased megakaryocytes (CD41+) and myeloid cells (CD11b+).
Reduced B (B220+) and T (CD3+) lymphocytes.
Upregulated the mRNA levels of IGFbp2/3, Angpt2, DLL4, DHH, and VEGF-A.
Downregulated the levels of FGF1 and CSF2.
Animal Model: 1×107 PK-1 cells injected male SCID mice (6-8 weeks)[2]
Dosage: 250 μg
Administration: Intraperitoneal injection (i.p.), twice a week, for 5 weeks
Result: Significantly inhibited tumor volume.
Significantly reduced the generation and density of blood vessels.
Did not cause significant toxicity or tissue damage.
Animal Model: Ldlr-/- mice and Lepob/Lepob mice with a high fat and high cholesterol diet (8 weeks)[3]
Dosage: 250 μg
Administration: Intraperitoneal injection (i.p.), twice a week, for 12 weeks
Result: Reduced plaque area and MCP-1 and macrophage infiltration.
Increased collagen and reduced calcification.
Reduced fat weight and made fat cells smaller.
Reduced fasting insulin levels.
Decreased NF-κB activity and expression of pro-inflammatory cytokines (IL-1β, iNOS, IL-6).
Animal Model: TDI (0.3% ear application and 3% nebulized inhalation) induced female BALB/c mice (6-8 weeks)[4]
Dosage: 250 μg
Administration: Intraperitoneal injection (i.p.), on day 15, 18 and 21
Result: Significantly reduced airway hyperreactivity (AHR) and airway inflammation score.
Significantly improved epithelial damage.
Significantly reduced the total number of inflammatory cells in bronchoalveolar lavage fluid (BALF), collagen deposition and airway smooth muscle (α-SMA).
Significant decreased in the proportion of Th17 and Th1 cells.
Significant decreased in IL-17A and RORγt levels.
Gene ID

54485  [NCBI]

Accession
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

SMILES

[Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2)NotchInterleukin RelatedNF-κBVEGFRFGFRNO SynthaseILNuclear factor-κBNuclear factor-kappaBVascular endothelial growth factor receptorFibroblast growth factor receptorNitric oxide synthasesNOSDelta-like protein 4/DLL4IL-1βiNOSIL-6IL-17Avascular densitymacrophageatherosclerosisasthmaPK-1Inhibitorinhibitorinhibit

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Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2)
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