2. Metabolic Enzyme/Protease Apoptosis Immunology/Inflammation Neuronal Signaling
  3. ELOVL Apoptosis NOD-like Receptor (NLR) Caspase Tau Protein
  4. Mouse Serum Albumin

Mouse Serum Albumin is most abundant protein in plasma, which leaks into the brain parenchyma when the blood-brain barrier (BBB) is impaired. Mouse Serum Albumin induces astrocytes to A1 phenotype to remarkably increase levels of Elovl1. Mouse Serum Albumin promotes VLSFAs secretion and causes neuronal lippoapoptosis through endoplasmic reticulum stress response pathway. MSA-activated microglia triggeres remarkable tau phosphorylation at multiple sites (Ser202/Thr205) through NLRP3 inflammasome pathway. Mouse Serum Albumin decreases the spatial learning and memory abilities in mice. Mouse Serum Albumin can be used for the study of neurodegenerative diseases like Alzheimer’s disease (AD) and frontotemporal dementia (FTD).

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Mouse Serum Albumin

Mouse Serum Albumin Chemical Structure

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Mouse Serum Albumin Related Antibodies

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Description

Mouse Serum Albumin is most abundant protein in plasma, which leaks into the brain parenchyma when the blood-brain barrier (BBB) is impaired. Mouse Serum Albumin induces astrocytes to A1 phenotype to remarkably increase levels of Elovl1. Mouse Serum Albumin promotes VLSFAs secretion and causes neuronal lippoapoptosis through endoplasmic reticulum stress response pathway. MSA-activated microglia triggeres remarkable tau phosphorylation at multiple sites (Ser202/Thr205) through NLRP3 inflammasome pathway. Mouse Serum Albumin decreases the spatial learning and memory abilities in mice. Mouse Serum Albumin can be used for the study of neurodegenerative diseases like Alzheimer’s disease (AD) and frontotemporal dementia (FTD)[1].

In Vitro

Mouse Serum Albumin (7 uM, 48 h) significantly reduces average branch length, number of end-point voxels and branches of primary neurons[1].
Mouse Serum Albumin (7 uM, 24 h) upregulates Elovl1 mRNA and protein levels in primary astrocyte [1].
Mouse Serum Albumin (7 uM, 48 h) induces significant neuronal apoptosis, with increased Tunel-positive cells in primary neurons[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mouse Serum Albumin Related Antibodies
In Vivo

Mouse Serum Albumin (1 μL per injection, intracerebroventricular injection, every 4 days for 16 days) impairs spatial learning and memory in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 2-month-old female C57BL/6J mice[1]
Dosage: 1 μL per injection
Administration: Intracerebroventricular injection every 4 days for 16 days
Result: Achieved impaired spatial learning and memory.
Induced increased neuronal apoptosis in hippocampus and neuroinflammation (enhanced microgliosis/astrogliosis, upregulated brain levels of IL-1β, IL-6 and TNF-α).
Promoted tau phosphorylation (increased p-tau at Ser202/Thr205) via activating NLRP3 inflammasome (upregulated NLRP3, ASC, cleaved caspase-1) and downstream IL-1β/IL-18-GSK3β/CaMKIIα pathway.
Downregulated M0 phenotype and phagocytosis-related genes and upregulated MGnD and inflammation-related genes in microglia.
Upregulated A1 astrocyte and inflammation genes and activated VLSFAs elongation pathway in astrocytes.
Downregulated mitochondrial β-oxidation, electron transport and GABA transmission-related genes in neurons.
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[Mouse Serum Albumin]
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Mouse Serum Albumin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mouse Serum AlbuminELOVLApoptosisNOD-like Receptor (NLR)CaspaseTau ProteinElongation of Very Long-chain Fatty AcidsElongaseMouse serum albuminNeuroinflammationTau phosphorylationInhibitorinhibitorinhibit

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