2. Metabolic Enzyme/Protease
  3. HMG-CoA Reductase (HMGCR)
  4. Bemfivastatin hemicalcium

Bemfivastatin hemicalcium  (Synonyms: PPD 10558 hemicalcium)

Cat. No.: HY-106281A Purity: 98.00%
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Bemfivastatin (PPD 10558) hemicalcium is an orally active HMG-CoA Reductase (HMGCR) inhibitor. Bemfivastatin hemicalcium enhances the activity of liver extraction and reduces blood lipid levels. Bemfivastatin hemicalcium can be used for research of metabolic disease, such as hypercholesterolemia.

For research use only. We do not sell to patients.

Bemfivastatin hemicalcium

Bemfivastatin hemicalcium Chemical Structure

CAS No. : 805241-64-9

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Based on 1 publication(s) in Google Scholar

Other Forms of Bemfivastatin hemicalcium:

Bemfivastatin hemicalcium Related Antibodies

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Description

Bemfivastatin (PPD 10558) hemicalcium is an orally active HMG-CoA Reductase (HMGCR) inhibitor. Bemfivastatin hemicalcium enhances the activity of liver extraction and reduces blood lipid levels. Bemfivastatin hemicalcium can be used for research of metabolic disease, such as hypercholesterolemia[1][2].

In Vivo

Bemfivastatin hemicalcium (20-320 mg/kg, p.o., daily from day 6 to 17) shows no maternal and developmental toxicity in pregnant rats[1].
Bemfivastatin hemicalcium (12.5-50 mg/kg, p.o., daily from day 6 to 18) causes mortality, abortions and body weight reduction in pregnant rabbits[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Pregnant rabbits[1]
Dosage: 12.5, 25 and 50 mg/kg
Administration: Orally administration, daily from day 6 to 18
Result: Showed 1 rabbit death at 25 mg/kg and 7 at 50 mg/kg.
Showed 2 rabbit abortions 25 mg/kg and 6 at 50 mg/kg.
Showed reduction in gestation body weight and decreased food consumption.
Molecular Weight

607.74

Formula

C34H37FN2O6.1/2Ca
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[O-]C(C[C@H](O)C[C@H](O)CCN1C(C2=CC=C(F)C=C2)=C(C3=CC=CC=C3)C(C(NC4=CC=C(CO)C=C4)=O)=C1C(C)C)=O.[Ca+2].[1/2]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : < 1 mg/mL (insoluble or slightly soluble)

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
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Bemfivastatin hemicalcium Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bemfivastatin hemicalcium805241-64-9PPD 10558 hemicalciumHMG-CoA Reductase (HMGCR)HMG-CoAHMGCRBlood lipidHypercholesterolemiaDyslipidaemiaInhibitorinhibitorinhibit

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