2. Apoptosis Immunology/Inflammation
  3. TNF Receptor IFNAR
  4. Anti-Mouse CD40L/CD154 Antibody (MR-1)

Anti-Mouse CD40L/CD154 Antibody (MR-1) 

Cat. No.: HY-P990134 Purity: 99.62%
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Anti-Mouse CD40L/CD154 Antibody (MR-1) is an anti-mouse CD40L/CD154 IgG monoclonal antibody. Anti-Mouse CD40L/CD154 Antibody (MR-1) reduces the expression of IFN signaling pathway and lowers the level of IFN-β. Anti-Mouse CD40L/CD154 Antibody (MR-1) can prolong the survival time of transplants. Anti-Mouse CD40L/CD154 Antibody (MR-1) can be used for research on cancer, inflammation conditions and xenotransplantation such as pancreatic cancer and autoimmune cholangitis.

For research use only. We do not sell to patients.

Anti-Mouse CD40L/CD154 Antibody (MR-1) Chemical Structure

Anti-Mouse CD40L/CD154 Antibody (MR-1) Chemical Structure

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Description

Anti-Mouse CD40L/CD154 Antibody (MR-1) is an anti-mouse CD40L/CD154 IgG monoclonal antibody. Anti-Mouse CD40L/CD154 Antibody (MR-1) reduces the expression of IFN signaling pathway and lowers the level of IFN-β. Anti-Mouse CD40L/CD154 Antibody (MR-1) can prolong the survival time of transplants. Anti-Mouse CD40L/CD154 Antibody (MR-1) can be used for research on cancer, inflammation conditions and xenotransplantation such as pancreatic cancer and autoimmune cholangitis[1][2][3].

IC50 & Target

CD40L/CD154
In Vitro

Anti-Mouse CD40L/CD154 Antibody (MR-1) (200 μg/mL, 48 h) significantly inhibits the production of IFN-β in natural killer T (NKT) cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse CD40L/CD154 Antibody (MR-1) Related Antibodies

ELISA Assay[1]

Cell Line: NKT cells, co-cultivation with peritoneal macrophages
Concentration: 200 μg/mL
Incubation Time: 48 h
Result: Reduced the level of IFN-β.
In Vivo

Anti-Mouse CD40L/CD154 Antibody (MR-1) (500 μg, i.p., once every 2 days, from 2 days before tumor inoculation to 12 days after inoculation) significantly reduces the expression of type I IFN signaling pathway related genes in male C57BL/6J mice bearing KPC1242 tumors[1].
Anti-Mouse CD40L/CD154 Antibody (MR-1) (20 mg/kg, i.p., once daily for 4 days at 1 day before surgery, once a week until the end of the experiment) extends the survival time of human neural stem cells (hNSCs) in 5XFAD transgenic mice[2].
Anti-Mouse CD40L/CD154 Antibody (MR-1) (25 mg/kg, i.p., on day 0, 2, 4 and 7 for initial stage, once weekly for maintenance stage) can temporarily delay the progression of cholangitis in dnTGFβRII mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 1×104 KPC1242 cells injected male C57BL/6J mice (8-12 weeks)[1]
Dosage: 500 μg
Administration: Intraperitoneal injection (i.p.), once every 2 days, from 2 days before tumor inoculation to 12 days after inoculation
Result: Significantly reduced the expression of IFN signaling pathway.
Animal Model: 5XFAD transgenic mice[2]
Dosage: 20 mg/kg
Administration: Intraperitoneal injection (i.p.), once daily for 4 days at 1 day before surgery, once a week until the end of the experiment
Result: Extended the survival time of hNSCs to 34 weeks.
Significantly suppressed transplant rejection reaction.
Animal Model: dnTGFβRII mice (3-4 weeks)[3]
Dosage: 25 mg/kg
Administration: Intraperitoneal injection (i.p.), on day 0, 2, 4 and 7 for initial stage, once weekly for maintenance stage
Result: Significantly reduced portal vein inflammation and bile duct injury scores for short-term treatment.
Reduced intrahepatic NKT cells and effector T cells in short-term treatment.
Reduced the level of IFN-γ, IL-4 and IL-17A for short-term treatment.
Gene ID

21947  [NCBI]

Accession
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse CD40L/CD154 Antibody (MR-1)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 99.62%

SDS (251 KB)

COA (232 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Anti-Mouse CD40L/CD154 Antibody (MR-1) Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD40L/CD154 Antibody (MR-1)TNF ReceptorIFNARTumor Necrosis Factor ReceptorTNFRInterferon-α/β receptorInterferon-alpha/beta receptorCD40L/CD154IFNtransplantsKPC1242Inhibitorinhibitorinhibit

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