2. GPCR/G Protein Neuronal Signaling
  3. Cholecystokinin Receptor
  4. CHEMBL333994

CHEMBL333994 (FK-480) is a potent and orally active Cholecystokinin A receptor (CCK-A receptor) antagonist, with an IC50 of 0.67 nM. CHEMBL333994 selectively antagonizes peripheral CCK receptors. CHEMBL333994 increases CCK mRNA level. CHEMBL333994 can be used for research of chronic pancreatitis.

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CHEMBL333994

CHEMBL333994 Chemical Structure

CAS No. : 167820-10-2

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Based on 1 publication(s) in Google Scholar

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CHEMBL333994 Related Antibodies

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CCKAR CCKBR

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Description

CHEMBL333994 (FK-480) is a potent and orally active Cholecystokinin A receptor (CCK-A receptor) antagonist, with an IC50 of 0.67 nM. CHEMBL333994 selectively antagonizes peripheral CCK receptors. CHEMBL333994 increases CCK mRNA level. CHEMBL333994 can be used for research of chronic pancreatitis[1][2][3].

IC50 & Target

CCKAR

 

Cellular Effect
Cell Line Type Value Description References
U-937 IC50
> 100 μM
Compound: 2
Inhibition of phosphodiesterase 4 extracted from human U937 cells by using radioligands [3H]-cAMP or [3H]cGMP.
Inhibition of phosphodiesterase 4 extracted from human U937 cells by using radioligands [3H]-cAMP or [3H]cGMP.
[PMID: 10636238]
Molecular Weight

438.45

Formula

C26H19FN4O2
CAS No.
SMILES

O=C(C(N1)=CC2=C1C=CC=C2)N[C@H]3C(N4C5=C(CC4)C=CC=C5C(C6=CC=CC=C6F)=N3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CHEMBL333994 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CHEMBL333994167820-10-2FK-480CHEMBL 333994CHEMBL-333994FK480FK 480Cholecystokinin ReceptorCCK ReceptorpancreatitisCCKInhibitorinhibitorinhibit

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