2. Apoptosis
  3. Apoptosis
  4. Olsalazine Disodium

Olsalazine Disodium is an orally active prodrug of 5-ASA (HY-15027). Olsalazine Disodium can inhibit cells proliferation and induce apoptosis. Olsalazine Disodium can reduce DAI and MPO activity and inhibit inflammatory cytokines levels. Olsalazine Disodium can be used for the researches of cancer, inflammation and metabolic disease, such as colorectal cancer, inflammatory bowel disease (IBD) and hyperuricemic.

For research use only. We do not sell to patients.

Olsalazine Disodium

Olsalazine Disodium Chemical Structure

CAS No. : 6054-98-4

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
500 mg In-stock
1 g In-stock
5 g In-stock
10 g In-stock
50 g   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Olsalazine Disodium:

Olsalazine Disodium Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Olsalazine Disodium

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Olsalazine Disodium is an orally active prodrug of 5-ASA (HY-15027). Olsalazine Disodium can inhibit cells proliferation and induce apoptosis. Olsalazine Disodium can reduce DAI and MPO activity and inhibit inflammatory cytokines levels. Olsalazine Disodium can be used for the researches of cancer, inflammation and metabolic disease, such as colorectal cancer, inflammatory bowel disease (IBD) and hyperuricemic[1][2][3][4].

In Vitro

Olsalazine Disodium (0-30 μM, 48 h) reduces cell viability in canine lymphoid tumor cell[4].
Olsalazine Disodium (0.19-1.64 μM, 24 h) induces apoptosis in canine lymphoid tumor cell[4].
Olsalazine Disodium (0.03 μM, 48 h) increases 5-mC levels of genomic DNA in canine lymphoid tumor cell lines[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Olsalazine Disodium Related Antibodies
In Vivo

Olsalazine Disodium (25 mg/kg, i.g., daily for 3 weeks) inhibits tumor growth in colorectal cancer rats models[1].
Olsalazine Disodium (50 mg/kg, p.o., daily for 11 days) ameliorates colitis companied with Cannabidiol in dextran sulphate sodium (DSS)-induced acute and chronic colitis mice models[2].
Olsalazine Disodium (5-20 mg/kg) decreases the levels of serum urate in hyperuricemic rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Colorectal cancer rats models[1]
Dosage: 25 mg/kg
Administration: Orally gavage, daily for 3 weeks
Result: Reduced the numbers of ACF and tumors.
Increased apoptotic cells and inhibited proliferation of tumor.
Animal Model: Dextran sulphate sodium (DSS)-induced acute and chronic colitis mice models[2]
Dosage: 50 mg/kg, companied with Cannabidiol (10 mg/kg)
Administration: Orally administration, daily for 11 days
Result: Reduced DAI, MPO activity, and inflammatory cytokines.
Restored colon length and GLP-1 levels.
Animal Model: Hyperuricemic rats[3]
Dosage: 5, 10 and 20 mg/kg
Administration: Intraperitoneally injection
Result: Reduced the levels of serum urate.
Reduced GLUT9, OAT3, OAT1 and NPT1 levels.
Clinical Trial
Molecular Weight

346.20

Formula

C14H8N2Na2O6
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(O[Na])C1=C(O)C=CC(/N=N/C2=CC(C(O[Na])=O)=C(O)C=C2)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (144.43 mM; Need ultrasonic)

DMSO : 20 mg/mL (57.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8885 mL 14.4425 mL 28.8850 mL
5 mM 0.5777 mL 2.8885 mL 5.7770 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 15 mg/mL (43.33 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.82%

SDS (393 KB)

COA (247 KB) HNMR (264 KB) LCMS (95 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 2.8885 mL 14.4425 mL 28.8850 mL 72.2126 mL
5 mM 0.5777 mL 2.8885 mL 5.7770 mL 14.4425 mL
10 mM 0.2889 mL 1.4443 mL 2.8885 mL 7.2213 mL
15 mM 0.1926 mL 0.9628 mL 1.9257 mL 4.8142 mL
20 mM 0.1444 mL 0.7221 mL 1.4443 mL 3.6106 mL
25 mM 0.1155 mL 0.5777 mL 1.1554 mL 2.8885 mL
30 mM 0.0963 mL 0.4814 mL 0.9628 mL 2.4071 mL
40 mM 0.0722 mL 0.3611 mL 0.7221 mL 1.8053 mL
50 mM 0.0578 mL 0.2889 mL 0.5777 mL 1.4443 mL
H2O 60 mM 0.0481 mL 0.2407 mL 0.4814 mL 1.2035 mL
80 mM 0.0361 mL 0.1805 mL 0.3611 mL 0.9027 mL
100 mM 0.0289 mL 0.1444 mL 0.2889 mL 0.7221 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Olsalazine Disodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Olsalazine Disodium6054-98-4Apoptosis5-ASADAIMPOColorectal cancerIBDHyperuricemicInhibitorinhibitorinhibit

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