Argininosuccinic acid disodium

Name: Argininosuccinic acid disodium
Brand: MedChemExpress
SKU: HY-113149A
Rating: 4.5 (1 reviews)

Cat. No.: HY-113149A Purity: 96.93%: Data Sheet
SDS

COA
Handling Instructions
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Argininosuccinic acid disodium is an intermediate metabolite in the urea cycle, and its level is associated with argininosuccinic aciduria. Argininosuccinic acid disodium can induce oxidative stress, leading to lipid and protein oxidation, reduction of glutathione, and decrease in antioxidant enzyme activity. Argininosuccinic acid disodium can be converted into guanidinosuccinic acid, a nitric oxide mimic, under the action of nitric oxide-derived free radicals. Argininosuccinic acid disodium can be used in the research of metabolic diseases, renal failure, nervous system diseases, etc.

For research use only. We do not sell to patients.

Argininosuccinic acid disodium Chemical Structure

CAS No. : 918149-29-8

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Argininosuccinic acid disodium:

Argininosuccinic acid Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Argininosuccinic acid (250-1000 μM; 1 h) disodium can reduce the concentration of reduced glutathione (GSH) and sulfhydryl content, increase the levels of malondialdehyde and carbonyl formation, induce protein oxidative damage, and promote the production of ROS in the cerebral cortex and striatum of rats in vitro^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Argininosuccinic acid (2 μM in 2 μL; intrastriatal administration; single dose) disodium significantly induces oxidative stress in 30-day-old rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	30-day-old male Wistar rats^[1]
Dosage:	2 μL of a 1.0 M concentration (2 μM in 2 μL)
Administration:	Intrastriatal administration; single dose
Result:	Significantly induced lipid oxidation (MDA levels) and protein oxidation (carbonyl formation), increased ROS and RNS generation (DCFH oxidation). Significantly decreased GSH concentrations.

Molecular Weight

334.24

Formula

C₁₀H₁₆N₄Na₂O₆

CAS No.

918149-29-8

Appearance

Solid

Color

White to off-white

SMILES

OC([C@@H](N)CCCNC(N[C@H](C(O[Na])=O)CC(O[Na])=O)=N)=O

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (149.59 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9919 mL	14.9593 mL	29.9186 mL
5 mM	0.5984 mL	2.9919 mL	5.9837 mL
10 mM	0.2992 mL	1.4959 mL	2.9919 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 96.93%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (245 KB) Elemental Analysis Report (104 KB)

Handling Instructions (2659 KB)

References

[1]. Seminotti B, et al. Free Radical Scavengers Prevent Argininosuccinic Acid-Induced Oxidative Stress in the Brain of Developing Rats: a New Adjuvant Therapy for Argininosuccinate Lyase Deficiency? Mol Neurobiol. 2020 Feb;57(2):1233-1244. [Content Brief]

[2]. Erez A, et al. Argininosuccinate lyase deficiency-argininosuccinic aciduria and beyond. Am J Med Genet C Semin Med Genet. 2011 Feb 15;157C(1):45-53. [Content Brief]

[3]. Aoyagi K, et al. Formation of guanidinosuccinic acid, a stable nitric oxide mimic, from argininosuccinic acid and nitric oxide-derived free radicals. Free Radic Res. 1999 Jul;31(1):59-65. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.9919 mL	14.9593 mL	29.9186 mL	74.7966 mL
	5 mM	0.5984 mL	2.9919 mL	5.9837 mL	14.9593 mL
	10 mM	0.2992 mL	1.4959 mL	2.9919 mL	7.4797 mL
	15 mM	0.1995 mL	0.9973 mL	1.9946 mL	4.9864 mL
	20 mM	0.1496 mL	0.7480 mL	1.4959 mL	3.7398 mL
	25 mM	0.1197 mL	0.5984 mL	1.1967 mL	2.9919 mL
	30 mM	0.0997 mL	0.4986 mL	0.9973 mL	2.4932 mL
	40 mM	0.0748 mL	0.3740 mL	0.7480 mL	1.8699 mL
	50 mM	0.0598 mL	0.2992 mL	0.5984 mL	1.4959 mL
	60 mM	0.0499 mL	0.2493 mL	0.4986 mL	1.2466 mL
	80 mM	0.0374 mL	0.1870 mL	0.3740 mL	0.9350 mL
	100 mM	0.0299 mL	0.1496 mL	0.2992 mL	0.7480 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.