Argininosuccinic acid 

Argininosuccinic acid is an intermediate metabolite in the urea cycle, and its level is associated with argininosuccinic aciduria. Argininosuccinic acid can induce oxidative stress, leading to lipid and protein oxidation, reduction of glutathione, and decrease in antioxidant enzyme activity. Argininosuccinic acid can be converted into guanidinosuccinic acid, a nitric oxide mimic, under the action of nitric oxide-derived free radicals. Argininosuccinic acid can be used in the research of metabolic diseases, renal failure, nervous system diseases, etc^[1][2][3].

Argininosuccinic acid (250-1000 μM; 1 h) can reduce the concentration of reduced glutathione (GSH) and sulfhydryl content, increase the levels of malondialdehyde and carbonyl formation, induce protein oxidative damage, and promote the production of ROS in the cerebral cortex and striatum of rats in vitro^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Argininosuccinic acid (2 μM for 2 μL; intrastriatal administration; single dose) significantly induces oxidative stress in 30-day-old rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

290.27

C₁₀H₁₈N₄O₆

2387-71-5

OC([C@@H](N)CCCNC(N[C@H](C(O)=O)CC(O)=O)=N)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Seminotti B, et al. Free Radical Scavengers Prevent Argininosuccinic Acid-Induced Oxidative Stress in the Brain of Developing Rats: a New Adjuvant Therapy for Argininosuccinate Lyase Deficiency? Mol Neurobiol. 2020 Feb;57(2):1233-1244.  [Content Brief]

  [2]. Erez A, et al. Argininosuccinate lyase deficiency-argininosuccinic aciduria and beyond. Am J Med Genet C Semin Med Genet. 2011 Feb 15;157C(1):45-53.  [Content Brief]

  [3]. Aoyagi K, et al. Formation of guanidinosuccinic acid, a stable nitric oxide mimic, from argininosuccinic acid and nitric oxide-derived free radicals. Free Radic Res. 1999 Jul;31(1):59-65.  [Content Brief]