Search Result

Results for "

Oral diseases

" in MedChemExpress (MCE) Product Catalog:

By Targets:	11β-HSD (4) 15-PGDH (1) 5-HT Receptor (51) AAK1 (1) Acetyl-CoA Carboxylase (2) Acyltransferase (10) Adenosine Receptor (11) Adenylate Cyclase (2) Adrenergic Receptor (68) Akt (40) Aldehyde Dehydrogenase (ALDH) (3) Amine N-methyltransferase (1) Amino Acid Derivatives (3) Amino acid Transporter (1) Aminopeptidase (1) Aminotransferases (Transaminases) (1) AMPK (17) Amyloid-β (50) Anaplastic lymphoma kinase (ALK) (3) Androgen Receptor (4) Angiotensin Receptor (8) Angiotensin-converting Enzyme (ACE) (14) Antibiotic (60) Antifolate (4) AP-1 (3) Apelin Receptor (APJ) (4) Apical Sodium-Dependent Bile Acid Transporter (1) Apolipoprotein (3) Apoptosis (224) Arenavirus (3) Arginase (1) Arp2/3 Complex (1) Arrestin (2) Aryl Hydrocarbon Receptor (1) ASCT (2) ASK1 (2) ATF6 (2) Atg8/LC3 (2) Autophagy (79) Bacterial (112) Bcl-2 Family (16) Bcr-Abl (4) BCRP (3) Beta-lactamase (8) Beta-secretase (20) Biochemical Assay Reagents (24) Bombesin Receptor (2) Bradykinin Receptor (1) Btk (10) c-Fms (2) c-Met/HGFR (5) Calcium Channel (45) CaMK (1) Cannabinoid Receptor (4) Carbonic Anhydrase (7) Casein Kinase (1) Caspase (36) CaSR (9) Cathepsin (6) CCR (12) CD276/B7-H3 (1) CD38 (1) CD47 (1) CDK (27) CETP (1) CFTR (4) Chemerin Receptor (1) Chloride Channel (3) Cholecystokinin Receptor (3) Cholinesterase (ChE) (53) Claudin (1) CMV (2) Collagen (2) Complement System (5) COMT (9) COX (41) CX3CR1 (2) CXCR (12) Cyclin G-associated Kinase (GAK) (1) Cyclophilin (1) Cytochrome P450 (35) Dengue Virus (2) DGK (2) Dihydroorotate Dehydrogenase (2) Dipeptidyl Peptidase (5) Discoidin Domain Receptor (1) DNA Alkylator/Crosslinker (8) DNA/RNA Synthesis (9) Dopamine Receptor (61) Dopamine Transporter (3) Dopamine β-hydroxylase (3) Drug Derivative (9) Drug Intermediate (2) Drug Isomer (3) Drug Metabolite (13) DYRK (2) E-Selectin (3) E1/E2/E3 Enzyme (1) EBI2/GPR183 (2) EGFR (7) Elastase (1) Endogenous Metabolite (120) Endothelin Receptor (1) Epigenetic Reader Domain (6) Epoxide Hydrolase (2) ERK (26) Estrogen Receptor/ERR (5) Eukaryotic Initiation Factor (eIF) (1) FABP (1) Factor Xa (10) FATP (1) Fatty Acid Synthase (FASN) (5) Ferrochelatase (1) Ferroptosis (12) FGFR (3) FLAP (2) Flavivirus (2) FLT3 (1) Formyl Peptide Receptor (FPR) (1) FOXO (3) Fungal (26) FXR (9) G protein-coupled Bile Acid Receptor 1 (4) G Protein-coupled Receptor Kinase (GRK) (2) GABA Receptor (7) Galectin (1) Gap Junction Protein (3) GCGR (2) GLP Receptor (3) Glucocorticoid Receptor (9) Glucosylceramide Synthase (GCS) (14) GLUT (1) Glutaminase (4) Glutathione Peroxidase (7) Glutathione S-transferase (1) Glycosidase (7) GlyT (2) GnRH Receptor (5) GPR6 (1) GPR84 (1) GSK-3 (17) Guanylate Cyclase (7) HBV (3) HCV (4) HDAC (15) Hedgehog (1) Heme Oxygenase (HO) (9) Herbicide (2) HIF/HIF Prolyl-Hydroxylase (16) Histamine Receptor (46) Histone Acetyltransferase (4) Histone Demethylase (5) Histone Methyltransferase (9) HIV (21) HIV Protease (1) HMG-CoA Reductase (HMGCR) (1) HPV (1) HSP (9) HSV (6) Huntingtin (1) IAP (1) IFNAR (4) iGluR (29) IKK (1) IKZF Family (1) Imidazoline Receptor (3) Indoleamine 2,3-Dioxygenase (IDO) (1) Influenza Virus (14) Insecticide (1) Insulin Receptor (2) Integrin (14) Interleukin Related (95) IPK Superfamily (1) IRAK (7) IRE1 (2) Isotope-Labeled Compounds (107) Itk (1) JAK (29) JNK (13) Keap1-Nrf2 (34) KLF (1) Lactate Dehydrogenase (1) Leukotriene Receptor (3) Ligands for E3 Ligase (1) LIM Kinase (LIMK) (1) Lipase (1) Liposome (1) Lipoxygenase (5) LPL Receptor (12) LRRK2 (9) LXR (4) mAChR (22) Malonyl-CoA Decarboxylase (1) MAP3K (6) MAPKAPK2 (MK2) (2) MARCKS (2) MDM-2/p53 (2) MEK (5) Melanocortin Receptor (2) METTL3 (1) mGluR (18) Microtubule/Tubulin (5) Mineralocorticoid Receptor (5) Mitochondrial Metabolism (15) Mitophagy (7) Mitosis (3) MMP (24) Molecular Glues (4) Monoamine Oxidase (34) mTOR (20) MyD88 (3) Myosin (1) N-myristoyltransferase (1) Na+/K+ ATPase (2) nAChR (14) NADPH Oxidase (1) Necroptosis (3) Neprilysin (3) Neurokinin Receptor (2) Neuropeptide Y Receptor (1) Neurotensin Receptor (1) NF-κB (81) NKCC (4) NO Synthase (31) NOD-like Receptor (NLR) (33) Notch (9) Nuclear Factor of activated T Cells (NFAT) (3) Nuclear Hormone Receptor 4A/NR4A (1) OAT (3) OGA (3) Orexin Receptor (OX Receptor) (1) Organoid (6) Orthopoxvirus (13) Oxidative Phosphorylation (1) P-glycoprotein (5) P2X Receptor (6) P2Y Receptor (5) p38 MAPK (38) p62 (2) PAI-1 (2) PAK (1) Palmitoyl Protein Thioesterase (PPT) (1) Parasite (40) PARP (4) PCSK9 (1) PD-1/PD-L1 (1) PDGFR (3) PDHK (1) Penicillin-binding protein (PBP) (3) PERK (9) PGE synthase (2) Phosphatase (10) Phosphodiesterase (PDE) (51) Phospholipase (3) Phosphorylase (1) PI3K (42) PIKfyve (1) Pim (1) PINK1/Parkin (1) PKA (6) PKC (5) Platelet-activating Factor Receptor (PAFR) (2) Potassium Channel (25) PPAR (18) Prion Protein (3) Procollagen C Proteinase (1) Prolyl Endopeptidase (PREP) (1) Prostaglandin Receptor (16) PROTACs (2) Protease Activated Receptor (PAR) (4) Proteasome (5) Protein Arginine Deiminase (1) Proton Pump (27) Pyroptosis (2) Pyruvate Kinase (5) Quinone Reductase (1) RAD51 (2) Raf (2) RAR/RXR (2) Reactive Oxygen Species (ROS) (66) Reference Standards (199) Renin (8) RET (3) RIP kinase (8) ROR (3) ROS Kinase (1) RSV (2) S100 Protein (2) Salt-inducible Kinase (SIK) (2) SARS-CoV (18) Ser/Thr Protease (3) Serotonin Transporter (1) SHP2 (2) Sigma Receptor (5) Sirtuin (9) SOD (10) Sodium Channel (11) Src (5) STAT (24) Stearoyl-CoA Desaturase (SCD) (6) STING (3) STK33 (1) Succinate Receptor 1 (1) Survivin (2) Syk (5) TAM Receptor (1) Tau Protein (14) TGF-beta/Smad (11) TGF-β Receptor (7) Thrombin (11) Thrombopoietin Receptor (5) Thyroid Hormone Receptor (7) TNF Receptor (35) TNK1 (1) Toll-like Receptor (TLR) (15) Topoisomerase (5) Trace Amine-associated Receptor (TAAR) (1) Transmembrane Glycoprotein (3) Transthyretin (TTR) (1) Trk Receptor (6) TRP Channel (7) Tyrosinase (3) Tyrosine Hydroxylase (2) ULK (1) URAT1 (1) Vasopressin Receptor (2) VD/VDR (1) VEGFR (10) Virus Protease (7) VSV (1) Wee1 (1) Wnt (8) Xanthine Oxidase (1) YAP (1) α-synuclein (13) β-catenin (7) γ-secretase (10)
By Research Areas:	Cancer (440) Cardiovascular Disease (348) Endocrinology (112) Infection (203) Inflammation/Immunology (667) Metabolic Disease (253) Neurological Disease (676)
Click Chemistry:	Azide (1) Alkynes (9)
Oligonucleotides:	Preservatives (1) Fillers (1) Antisense Oligonucleotides (2) Cholesterol (1)

1676

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

266

Natural
Products

136

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100411

MLi-2 5+ Cited Publications	LRRK2	Neurological Disease
MLi-2 is an orally active and highly selective LRRK2 inhibitor with an IC₅₀ of 0.76 nM. MLi-2 has the potential for Parkinson’s disease .

HY-16743

Ibiglustat 3 Publications Verification Venglustat; SAR402671; GZ402671	Glucosylceramide Synthase (GCS)	Metabolic Disease
Ibiglustat (Venglustat) is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. Ibiglustat can be used for the research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease .

HY-16743B

Ibiglustat succinate 3 Publications Verification Venglustat succinate; SAR402671 succinate; GZ402671 succinate	Glucosylceramide Synthase (GCS)	Neurological Disease
Ibiglustat (Venglustat) succinate is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. Ibiglustat succinate can be used for the research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease .

HY-19490A

(S)-VQW-765 (S)-AQW-051	nAChR	Neurological Disease
(S)-VQW-765 ((S)-AQW-051) is an orally active, selective and effective α7 nicotinic ACh receptor (nAChR) partial agonist. (S)-VQW-765 has potential applications in cognitive disorders related to neurological diseases, such as Alzheimer's disease or schizophrenia .

HY-16743A

Ibiglustat (L-Malic acid) 3 Publications Verification Venglustat (L-Malic acid); SAR402671 (L-Malic acid); GZ402671 (L-Malic acid)	Glucosylceramide Synthase (GCS)	Metabolic Disease
Ibiglustat (Venglustat) L-Malic acid is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. Ibiglustat L-Malic acid can be used for the research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease .

HY-118284

Vicagrel 1 Publications Verification	P2Y Receptor	Cardiovascular Disease
Vicagrel is a potent, safe and orally active antiplatelet agent, which works by irreversibly inhibiting P2Y12 receptor. Vicagrel can be used for the research of blood clots in coronary artery disease, peripheral vascular disease, and cerebrovascular disease .

HY-138453

ACT-1016-0707 LPA1 receptor antagonist 2	LPL Receptor	Inflammation/Immunology
ACT-1016-0707 (Compound 49) is an orally active and selective LPA1 receptor antagonist. ACT-1016-0707 can be used for the research of fibrotic diseases .

HY-16743C

Ibiglustat hydrochloride Venglustat hydrochloride; SAR402671 hydrochloride; GZ402671 hydrochloride	Glucosylceramide Synthase (GCS)	Metabolic Disease
Ibiglustat hydrochloride is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. Ibiglustat hydrochloride can be used for the research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease .

HY-12995

BI 665915	FLAP	Cardiovascular Disease Inflammation/Immunology
BI 665915 is an orally active and potent 5-lipoxygenase-activating protein (FLAP) inhibitor. BI 665915 inhibits FLAP production that blocks LTB4 biosynthesis in mice. BI 665915 is promising for research of various inflammatory diseases, including respiratory and cardiovascular diseases .

HY-10594

Letaxaban TAK-442	Factor Xa	Cardiovascular Disease Inflammation/Immunology
Letaxaban (TAK-442) is an orally active and selective direct FXa inhibitor. Letaxaban is a drug with dual anticoagulant and anti-inflammatory activity that works by directly inhibiting FXa and by intervening in the PAR1 signaling pathway. Letaxaban can be used in the study of thrombotic diseases, cardiovascular diseases and inflammation-related diseases .

HY-128442

Phenyl sulfate Phenyl hydrogen sulfate	Endogenous Metabolite	Metabolic Disease
Phenyl sulfate is an orally active gut microbiota-derived metabolite. Phenyl sulfate induces albuminuria and podocyte damage in experimental models of diabetes. Phenyl sulfate can be used as a disease marker and future therapeutic target in diabetic kidney disease .

HY-122230

UR-3216	Integrin	Cardiovascular Disease
UR-3216 is a selective, and orally active platelet surface glycoprotein (GPIIb/IIIa) receptor antagonist. UR-3216 has the potential for cardiovascular diseases research .

HY-17020

Miglustat 5 Publications Verification N-Butyldeoxynojirimycin; NB-DNJ; OGT 918	Glucosylceramide Synthase (GCS)	Neurological Disease Inflammation/Immunology
Miglustat (N-Butyldeoxynojirimycin) is an orally active and reversible ceramide glucosyltransferase inhibitor. Miglustat can be used for the research of type I gaucher disease .

HY-N15719

Dipsacus saponin R	Others	Others
Dipsacus saponin R (Compound 1) is an orally active triterpenoid saponin found in Radix Dipsaci. Dipsacus saponin R promotes bone formation and repair by regulating osteoblast activity or inhibiting osteoclast function. Dipsacus saponin R is promising for research of bone diseases such as osteoporosis and fracture healing .

HY-17020A

Miglustat hydrochloride 5 Publications Verification N-Butyldeoxynojirimycin hydrochloride; NB-DNJ hydrochloride; OGT 918 hydrochloride	Glucosylceramide Synthase (GCS)	Neurological Disease Inflammation/Immunology
Miglustat (N-Butyldeoxynojirimycin) hydrochloride is an orally active and reversible ceramide glucosyltransferase inhibitor. Miglustat hydrochloride can be used for the research of type I gaucher disease .

HY-108287

Trithiozine	Others	Endocrinology
Trithiozine is an orally active antisecretory and antiulcer agent. Trithiozine can be used for the research of peptic ulcer disease and hypersecretory disorders .

HY-134661A

Solangepras 1 Publications Verification CVN424	GPR6	Neurological Disease
CVN424 is an orally active and selective GPR6 inverse agonist with a K_i of 9.4 nM and an EC₅₀ of 38 nM. CVN424 is brain-penetrant and has the potential for Parkinson disease research .

HY-113745

LX-6171	Amino acid Transporter	Neurological Disease
LX-6171 is an orally active SLC6A7 inhibitor. LX-6171 can be used to study diseases characterized by cognitive impairment, such as Alzheimer's disease, schizophrenia or vascular dementia .

HY-122164

LY-503430	iGluR	Neurological Disease
LY-503430 is an orally active AMPA receptor positive allosteric modulator (PAM). LY-503430 can be used for the study of Parkinson's disease .

HY-N7560

Safranal 5 Publications Verification	Keap1-Nrf2	Neurological Disease Inflammation/Immunology
Safranal is an orally active main component of Saffron (Crocus sativus) and is responsible for the unique aroma of this spice. Safranal has neuroprotective and anti-inflammatory effects and has the potential for Parkinson’s disease research .

HY-16747

Maralixibat chloride SHP625 chloride; LUM001 chloride; Lopixibat chloride	Apical Sodium-Dependent Bile Acid Transporter	Metabolic Disease
Maralixibat (SHP625) chloride is an orally active ileal bile acid transporter (IBAT) inhibitor. Maralixibat chloride can be used for the research of rare cholestatic liver diseases including Alagille syndrome (ALGS), progressive familial intrahepatic cholestasis (PFIC) and biliary atresia .

HY-125558

PT150 ORG-34517	Glucocorticoid Receptor	Neurological Disease
PT150 (ORG-34517) is a competitive and orally active glucocorticoid receptor antagonist. PT150 shows neuroprotective effects. PT150 has the potential for the research of Parkinson’s disease .

HY-177130S

Socrodeucitinib	JAK	Inflammation/Immunology
Socrodeucitinib (Compound Example 58) is an orally active and selective tyrosine kinase 2 (TYK2) inhibitor with an IC₅₀ value of 1.41 nM. Socrodeucitinib exerts anti-inflammatory activity by inhibiting TYK2-mediated cytokine signaling pathways and reducing the secretion of inflammatory factors. Socrodeucitinib is promising for research of autoimmune diseases such as psoriasis and inflammatory diseases .

HY-105003

ST 1535	Adenosine Receptor	Neurological Disease
ST 1535 is a potent and orally active A2A adenosine receptor antagonist. ST 1535 shows antiparkinsonian activity and antitremorigenic effects. ST 1535 has the potential for the research of Parkinson’s disease .

HY-16759B

Verubecestat tosylate MK-8931 tosylate	Beta-secretase	Neurological Disease
Verubecestat tosylate is an orally active, high-affinity BACE1 and BACE2 inhibitor with K_i values of 2.2 nM and 0.38 nM. Verubecestat tosylate effectively reduces Aβ40 and has the potential for Alzheimer's Disease .

HY-16748

Nelonicline ABT-126	nAChR	Neurological Disease
Nelonicline (ABT-126) is an orally active and selective α7 nicotinic receptor agonist with high affinity to α7 nAChRs in human brain (K_i=12.3 nM). Nelonicline is used for the research of shizophrenia and Alzheimer's disease .

HY-107002A

Lergotrile mesylate	Dopamine Receptor	Neurological Disease Endocrinology
Lergotrile mesylate is a potent and orally active dopamine agonist and a prolactin secretion inhibitor. Lergotrile mesylate inhibits prolactin release from pituitaries by activating an adenohypophyseal dopamine receptor. Lergotrile mesylate has the potential for the research of Parkinson's disease .

HY-111669

Zervimesine 1 Publications Verification CT1812; Sigma-2 receptor antagonist 1	Sigma Receptor	Neurological Disease
Zervimesine (CT1812) is an orally active and brain penetrant sigma-2 receptor antagonist with a K_i of 8.5 nM. Zervimesine can be used for the research of Alzheimer’s disease .

HY-174462

AChE-IN-90	Cholinesterase (ChE)	Neurological Disease
AChE-IN-90 (Compound 5b) is an orally active, brain-penetrant and potent acetylcholinesterase (AChE) inhibitor with an IC₅₀ value of 0.023 μM against human AChE and lower selectivity for butyrylcholinesterase (BuChE) (IC₅₀ 1.8 μM). AChE-IN-90 increases acetylcholine levels in the synaptic cleft. AChE-IN-90 is promising for research of neurodegenerative diseases such as Alzheimer's disease .

HY-16748A

Nelonicline citrate ABT-126 citrate	nAChR	Neurological Disease
Nelonicline (ABT-126) citrate is an orally active and selective α7 nicotinic receptor agonist with high affinity to α7 nAChRs in human brain (K_i=12.3 nM). Nelonicline citrate is used for the research of shizophrenia and Alzheimer's disease .

HY-128442R

Phenyl sulfate (Standard)	Endogenous Metabolite	Metabolic Disease
Phenyl sulfate (Standard) is the analytical standard of Phenyl sulfate. This product is intended for research and analytical applications. Phenyl sulfate is an orally active gut microbiota-derived metabolite. Phenyl sulfate induces albuminuria and podocyte damage in experimental models of diabetes. Phenyl sulfate can be used as a disease marker and future therapeutic target in diabetic kidney disease .

HY-16759

Verubecestat 4 Publications Verification MK-8931	Beta-secretase	Neurological Disease
Verubecestat (MK-8931) is an orally active, high-affinity BACE1 and BACE2 inhibitor with K_i values of 2.2 nM and 0.38 nM. Verubecestat effectively reduces Aβ40 and has the potential for Alzheimer's Disease .

HY-162076

AEP-IN-3	Cathepsin	Neurological Disease
AEP-IN-3 (compound 18) is an orally active, potent and brain penetrant asparagine endopeptidase (AEP) inhibitor, with an IC₅₀ of 7.8 ± 0.9 nM. AEP-IN-3 can be used for Alzheimer’s Disease (AD) research .

HY-16759A

Verubecestat TFA MK-8931 TFA	Beta-secretase	Neurological Disease
Verubecestat (MK-8931) TFA is an orally active, high-affinity BACE1 and BACE2 inhibitor with K_i values of 2.2 nM and 0.38 nM. Verubecestat TFA effectively reduces Aβ40 and has the potential for Alzheimer's Disease .

HY-N7560R

Safranal (Standard)	Keap1-Nrf2 Reference Standards	Neurological Disease Inflammation/Immunology
Safranal (Standard) is an analytical standard for Safranal. This product is intended for research and analytical applications. Safranal is the main component of saffron (Crocus sativus), is orally active, and is the source of the spice's unique aroma. Safranal has neuroprotective and anti-inflammatory effects and has research potential for Parkinson's disease.

HY-17020R

Miglustat (Standard)	Glucosylceramide Synthase (GCS)	Neurological Disease Inflammation/Immunology
Miglustat (Standard) is the analytical standard of Miglustat. This product is intended for research and analytical applications. Miglustat (N-Butyldeoxynojirimycin) is an orally active and reversible ceramide glucosyltransferase inhibitor. Miglustat can be used for the research of type I gaucher disease .

HY-117609

UE2343	11β-HSD	Neurological Disease
UE2343 is an orally available, brain-penetrant 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor. UE2343 is being investigated for the treatment of Alzheimer's disease .

HY-144619

TLR7/8 antagonist 2	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR7/8 antagonist 2 (Compound 15) is a potent and orally active agonist of TLR7/8 with IC₅₀s of 4.9 and 0.6 nM, respectively. Inappropriate activation of TLR7 and TLR8 is linked to several autoimmune diseases, such as lupus erythematosus. TLR7/8 antagonist 2 has the potential for the research of autoimmune diseases .

HY-17020AR

Miglustat hydrochloride (Standard)	Glucosylceramide Synthase (GCS)	Neurological Disease Inflammation/Immunology
Miglustat (hydrochloride) (Standard) is the analytical standard of Miglustat (hydrochloride). This product is intended for research and analytical applications. Miglustat (N-Butyldeoxynojirimycin) hydrochloride is an orally active and reversible ceramide glucosyltransferase inhibitor. Miglustat hydrochloride can be used for the research of type I gaucher disease .

HY-107355

Letosteine	Reactive Oxygen Species (ROS)	Inflammation/Immunology
Letosteine is an orally active, potent and safe expectorant. Letosteine has the effect of scavenging reactive oxygen species (ROS). Letosteine dissolves bronchial mucus and reduces respiratory inflammation symptoms, and restores gas exchanges and natural defense mechanisms in the lung. Letosteine can be used for acute or chronic respiratory diseases (such as bronchopneumopathies) research .

HY-135825

TFEB activator 1 5+ Cited Publications	Autophagy	Neurological Disease
TFEB activator 1 is an orally effective, mTOR-independent activator of TFEB. TFEB activator 1 significantly promotes the nuclear translocation of Flag-TFEB with an EC₅₀ of 2167 nM. TFEB activator 1 enhances autophagy without inhibiting the mTOR pathway and has the potential for neurodegenerative diseases treatment .

HY-124476

Cystamine 3 Publications Verification	Caspase Glutaminase Apoptosis	Cancer
Cystamine is the disulfide form of the free thiol, cysteamine. Cystamine is an orally active transglutaminase (Tgase) inhibitor. Cystamine also has inhibition activity for caspase-3 with an IC₅₀ value of 23.6 μM. Cystamine can be used for the research of severals diseases including Huntington's disease (HD) .

HY-W020050

Cystamine dihydrochloride 3 Publications Verification	Caspase Glutaminase Apoptosis	Neurological Disease Cancer
Cystamine (dihydrochloride) is the disulfide form of the free thiol, cysteamine. Cystamine is an orally active transglutaminase (Tgase) inhibitor. Cystamine also has inhibition activity for caspase-3 with an IC₅₀ value of 23.6 μM. Cystamine can be used for the research of severals diseases including Huntington's disease (HD) .

HY-157646

MZ-101 GYS1-IN-2	Others	Metabolic Disease
MZ-101 (GYS1-IN-2) is an orally active, potent and selective small-molecule glycogen synthase 1 (GYS1) inhibitor with with an IC₅₀ value of 0.041 µM. MZ-101 reduces glycogen concentrations in cells and in mice. MZ-101 can used to study GYS1 -mediated Pompe disease and other glycogen storage diseases .

HY-13764A

dl-Tetrandrine	Calcium Channel	Cardiovascular Disease Inflammation/Immunology Cancer
dl-Tetrandrine is an orally active and brain-penetrant calcium channel blocker that inhibits voltage-dependent calcium channels. dl-Tetrandrine selectively blocks Ca ²⁺ influx with an IC₅₀ value of approximately 1-10 μM. dl-Tetrandrine exerts anti-inflammatory, immunosuppressive, and anti-arrhythmic activities by inhibiting intracellular calcium overload, and can reverse multidrug resistance in tumor cells. dl-Tetrandrine is promising for research of autoimmune diseases (such as rheumatoid arthritis), cardiovascular diseases, and tumor drug resistance reversal .

HY-18039

WAY-361789 SEN15924	Cholinesterase (ChE)	Neurological Disease
WAY-361789 (SEN15924) is an orally active agonist for α7 nicotinic acetylcholine receptor (α7 nAChR) with an EC₅₀ of 0.18 μM. WAY-361789 improves the cognitive function, exhibits potential in ameliorating Alzheimer’s Disease and schizophrenia .

HY-108287R

Trithiozine (Standard)	Others	Endocrinology
Trithiozine (Standard) is the analytical standard of Trithiozine. This product is intended for research and analytical applications. Trithiozine is an orally active antisecretory and antiulcer agent. Trithiozine can be used for the research of peptic ulcer disease and hypersecretory disorders .

HY-101918

DS-1040 Tosylate	Thrombin	Cardiovascular Disease
DS-1040 Tosylate is an orally active, selective inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) with IC₅₀s of 5.92 nM and 8.01 nM for human and rat TAFIa. DS-1040 Tosylate is a fibrinolysis enhancer for thromboembolic diseases .

HY-145721A

Mongersen sodium GED-0301 sodium	TGF-beta/Smad	Inflammation/Immunology
Mongersen sodium is a specific and orally active SMAD7 antisense oligonucleotide. Mongersen sodium restores TGF-β1 activity leading to inhibition of inflammatory signals. Mongersen sodium can attenuate Crohn's disease-like experimental colitis in mice .

HY-B0203A

Nebivolol hydrochloride 3 Publications Verification R 065824 hydrochloride	Adrenergic Receptor	Cardiovascular Disease Endocrinology Cancer
Nebivolol (R 065824) hydrochloride is an orally active beta receptor blocker and has the high beta(1)-receptor affinity.Nebivolol hydrochloride has direct vasodilator properties and adrenergic blocking characteristics. Nebivolol hydrochloride can be used for the research of kinds of diseases such as hypertension, coronary artery disease, congestive heart failure and ischemic heart disease .

Cat. No.	Product Name

HY-L192

Dietary Supplement Library

70 compounds

Dietary supplement, also known as nutritional supplement or food supplement, include dietary components such as vitamins, minerals, and amino acids. The unique value of dietary supplement is particularly significant in the post-pandemic era. Compared to traditional medication, dietary supplement is often more readily accepted by the public due to their higher safety profile and the natural origin. By orally supplementing essential nutrients and bioactive substances, dietary supplement can help to enhance the body's health level and reduce the risk of diseases. For certain chronic conditions, proper dietary supplement can also serve as a powerful adjunct to conventional medical treatment, enhancing the effectiveness of medication.

MCE has included 70 dietary supplements, whose ingredients are all derived from the official lists published by authoritative organizations such as the FDA, EFSA, NMPA, etc. These compounds can be utilized in the development of health food products and for the mechanistic research of certain chronic diseases.

HY-L137

Molecular Glue Compound Library

73 compounds

Targeted protein degradation(TPD) is a novel and promising approach to new drug discovery and development. It shows great potential for treating diseases with “undruggable” pathogenic protein targets and for overcoming drug resistance. Molecular glues and PROTACs are both targeted protein degraders that have attracted the most attention.

Molecular glues are small molecular degraders that mainly induce novel interaction between an E3 ligase and a target protein to form a ternary complex, leading to protein ubiquitination and subsequent proteasome degradation. Compared with PROTACs, molecular glues generally possess more favorable drug-like properties, such as lower MW, higher cell permeability, and better oral absorption. Molecular glues are emerging as a promising new therapeutic strategy.

MCE supplies a unique collection of 73 molecular glues which target various proteins. MCE Molecular Glue Compound Library is a useful tool to conduct scientific research and disease mechanism study.

Cat. No.	Product Name	Type

HY-19948

Leucomethylene blue mesylate 5+ Cited Publications TRx0237 mesylate; Methylene blue leuco base mesylate	Chromogenic Assays
Leucomethylene blue (TRx0237) mesylate, an orally active second-generation tau protein aggregation inhibitor (K_i of 0.12 μM), could be used for the study of Alzheimer's Disease. Leucomethylene blue mesylate is a common reduced form of Methylene Blue, Methylene Blue is a member of the thiazine class of dyes .

HY-114491

Rineterkib

Fluorescent Dyes/Probes

Rineterkib (compound B) is an orally available ERK1 and ERK2 inhibitor in the treatment of a proliferative disease characterized by activating mutations in the MAPK pathway. The activity is particularly related to the treatment of KRAS-mutant NSCLC, BRAF-mutant NSCLC, KRAS-mutant pancreatic cancer, KRAS-mutant colorectal cancer (CRC) and KRAS-mutant ovarian cancer. Rineterkib hydrochloride can also inhibit RAF .

HY-10585AG

Valproic acid sodium (GMP)

Sodium Valproate (GMP); VPA sodium (GMP); 2-Propylpentanoic acid sodium (GMP)

Fluorescent Dye

Valproic acid (Sodium Valproate) sodium is an orally active HDAC inhibitor, with IC₅₀ in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC₅₀, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium is used in the treatment of epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches .

Cat. No.	Product Name	Type

HY-15908

BCA 5+ Cited Publications Disodium bicinchoninate	Biochemical Assay Reagents
BCA (Disodium bicinchoninate) is an orally active and non-competitive Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC₅₀ value of 28 µM, a K_i value of 43 µM. BCA shows anticancer activity. BCA has the potential for the research of Alzheimer's disease (AD) .

HY-47030

Ferric citrate hydrate	Microbial Culture
Ferric citrate hydrate, an orally active iron supplement, is an efficacious phosphate binder. Ferric citrate hydrate can be used for iron deficiency anemia and chronic kidney disease (CKD) research .

HY-B1278B

(±)-α-Tocopherol acetate (±)-Vitamin E acetate	Biochemical Assay Reagents
(±)-α-Tocopherol acetate ((±)-Vitamin E acetate), is a orally active synthetic form of vitamin E. (±)-α-Tocopherol acetate is the ester of acetic acid and α-tocopherol. (±)-α-Tocopherol acetate can be used for the research of the susceptibility of farmed fish to infectious diseases .

HY-B0757A

(±)-α-Tocopherol nicotinate rel-Vitamin E Nicotinate	Biochemical Assay Reagents
(±)-α-Tocopherol nicotinate, vitamin E - nicotinate, is an orally active fat-soluble antioxidant that prevents lipid peroxidation in cell membranes. (±)-α-Tocopherol nicotinate is hydrolysed in the blood to α -tocopherol and niacin and may be used in studies of related vascular diseases .

HY-Y1147

Diethyl maleate

1 Publications Verification

Maleic acid diethyl ester

Biochemical Assay Reagents

Diethyl maleate (DEM) is an orally available, effective glutathione (GSH) depletor that crosses the blood-brain barrier. Diethyl maleate covalently binds irreversibly to GSH via glutathione S-transferase with an in vitro IC50 of 0.1-0.5 mM. Diethyl maleate selectively depletes GSH in liver, lung, and brain tissues, exacerbating oxidative stress and enhancing hyperbaric oxygen toxicity. Diethyl maleate promotes precursor amino acid uptake and in turn promotes GSH synthesis by upregulating the activity of the cystine-glutamate transporter X_{O ^-}. Diethyl maleate can be used to study redox homeostasis and GSH protection mechanisms in oxidative stress-related diseases such as hyperbaric oxygen injury and metabolic diseases[1][2][3].

HY-Y0262B

Sodium oxalate,ACS,99.5% Ethanedioic acid sodium,ACS, 99.5%	Chelators
Sodium oxalate is an orally active dispersant and coordination agent. Sodium oxalate causes mitochondrial dysfunction. Sodium oxalate has catalytic enhancing activity. Sodium oxalate induces stable chronic kidney disease. Sodium oxalate induces highly malignant and undifferentiated breast tumors .

HY-B1278BR

(±)-α-Tocopherol acetate (Standard)

(±)-Vitamin E acetate (Standard)

Biochemical Assay Reagents

(±)-α-Tocopherol acetate (Standard) is the analytical standard of (±)-α-Tocopherol acetate. This product is intended for research and analytical applications. (±)-α-Tocopherol acetate ((±)-Vitamin E acetate), is a orally active synthetic form of vitamin E. (±)-α-Tocopherol acetate is the ester of acetic acid and α-tocopherol. (±)-α-Tocopherol acetate can be used for the research of the susceptibility of farmed fish to infectious diseases .

HY-W354753

Homatropine hydrochloride	Biochemical Assay Reagents
Homatropine hydrochloride is an orally active anticholinergic agent that rapidly dilates pupils and has cycloplegic effects. Homatropine hydrochloride also has antitussive activity. Homatropine hydrochloride can be used in research on eye diseases and coughs .

HY-B0757AR

(±)-α-Tocopherol nicotinate (Standard)

rel-Vitamin E Nicotinate (Standard)

Biochemical Assay Reagents

(±)-α-Tocopherol nicotinate (Standard) is the analytical standard of (±)-α-Tocopherol nicotinate. This product is intended for research and analytical applications. (±)-α-Tocopherol nicotinate, vitamin E - nicotinate, is an orally active fat-soluble antioxidant that prevents lipid peroxidation in cell membranes. (±)-α-Tocopherol nicotinate is hydrolysed in the blood to α -tocopherol and niacin and may be used in studies of related vascular diseases[1][2].

HY-W354753R

Homatropine hydrochloride (Standard)

Biochemical Assay Reagents

Homatropine (hydrochloride) (Standard) is the analytical standard of Homatropine (hydrochloride). This product is intended for research and analytical applications. Homatropine hydrochloride is an orally active anticholinergic agent that rapidly dilates pupils and has cycloplegic effects. Homatropine hydrochloride also has antitussive activity. Homatropine hydrochloride can be used in research on eye diseases and coughs .

HY-B0617

S-Adenosyl-L-methionine Maximum Cited Publications 15 Publications Verification S-Adenosyl methionine; Ademetionine; AdoMet	Biochemical Assay Reagents
S-Adenosyl-L-methionine (S-Adenosyl methionine) is an orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine has the potential for, cancer, liver disease and osteoarthritis research .

HY-109521A

Manganese chloride (tetrahydrate), molecular biology grade,≥99.0% (KT)

Manganese(Ⅱ) chloride (tetrahydrate), molecular biology grade,≥99.0% (KT)

Buffer Reagents

Manganese chloride (tetrahydrate), molecular biology grade,≥99.0% (KT) is an orally active and a blood-brain barrier penetrant compound. It affects the activities of multiple enzymes in cells, such as regulating the activities of histone acetyltransferase (HAT) and histone deacetylase (HDAC), thereby affecting gene expression. It has multiple activities such as neurotoxicity, embryotoxicity, and reproductive toxicity. It is currently mainly used in neurodegenerative diseases and toxicology research.

HY-W014841

Sodium hippurate, 98%

N-Benzoylglycine sodium, 98%

Microbial Culture

Sodium hippurate, 98% is an orally active metabolite. Sodium hippurate, 98% can be produced by intestinal microorganisms from the metabolism of polyphenols, benzoic acid. Sodium hippurate, 98% decreases NRF2, MMP9 and leads to ROS accumulation. Sodium hippurate, 98% activates TGFβ/SMAD signaling. Sodium hippurate, 98% improves hyperuricemia and colitis. Sodium hippurate, 98% can also be used in cardiovascular disease research . .

HY-10585AG

Valproic acid sodium (GMP)

Sodium Valproate (GMP); VPA sodium (GMP); 2-Propylpentanoic acid sodium (GMP)

Biochemical Assay Reagents

HY-W015854

Ethyl methanesulfonate

Biochemical Assay Reagents

Ethyl methanesulfonate is an orally active biochemical agent. Ethyl methanesulfonate induces Apoptosis. Ethyl methanesulfonate acts on DNA, alkylating it and causing changes in DNA structure, which in turn triggers a series of biological effects such as mutation and cell death. Ethyl methanesulfonate induces kidney and nervous system tumors. Ethyl methanesulfonate is widely used in the field of genetic toxicology research and is often used to induce gene mutations in organisms to study gene function, the mechanism of genetic diseases, and the effects of environmental mutagenic factors, etc .

HY-W251428

Phosphatidylglycerols (egg) sodium salt

Egg PG

Drug Delivery

Phosphatidylglycerols (PG) is a selective inhibitor targeting the TLR4 accessory protein CD14/MD-2 complex, inhibiting LPS or virus (such as RSV)-mediated inflammatory signaling pathways through competitive binding. Phosphatidylglycerols directly bind to viral particles to block infection, inhibit COX-2 expression to reduce the release of inflammatory factors (IL-6, IL-8), and improve oxidative stress by regulating mitochondrial membrane phospholipid remodeling. Phosphatidylglycerols can be taken orally or by inhalation and can be used in the study of chronic inflammatory diseases (such as atherosclerosis) and respiratory viral infections (such as RSV) .

HY-W013636C

2-Ketoglutaric acid potassium

5 Publications Verification

Alpha-Ketoglutaric acid potassium

Biochemical Assay Reagents

2-Ketoglutaric acid (Alpha-Ketoglutaric acid) (potassium) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid potassium is a reversible and orally active inhibitor of tyrosinase with an IC₅₀ value of 15 mM. 2-Ketoglutaric acid potassium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid potassium significantly suppresses abnormal intestinal permeability, delocalization of tight junction proteins from the intestinal cells, expression of TNFα in vitro and in vivo. 2-Ketoglutaric acid potassium directly binds to TAK1, and inhibits the TRAF6-TAK1 interaction. 2-Ketoglutaric acid potassium also alleviates inflammatory bowel disease (IBD) symptoms and gut microbiota dysbiosis, evident by the improvements in the intestine length .

Cat. No.	Product Name	Target	Research Area

HY-P4153

Enlicitide chloride MK-0616 chloride	PCSK9	Cardiovascular Disease
Enlicitide chloride is an orally active inhibitor for PCSK9 that blocks the interaction between LPL receptor and PSCK9, with an IC₅₀ of 2.5 nM. Enlicitide chloride can be used in the study of cardiovascular diseases such as atherosclerosis, hypercholesterolemia, coronary heart disease, metabolic syndrome, acute coronary syndrome or related cardiovascular and cardiometabolic disorders .

HY-P3499

Dolcanatide	Guanylate Cyclase	Inflammation/Immunology
Dolcanatide is an orally active GC-C (guanylate cyclase-C) agonist. Dolcanatide shows laxative, anti-nociceptive and anti-inflammatory activity. Dolcanatide can be used in inflammatory bowel disease research .

HY-P10587

Icotrokinra JNJ-77242113; JNJ-2113; PN-235	Interleukin Related STAT	Inflammation/Immunology
Icotrokinra (JNJ-77242113) is an orally available, selective antagonist of the IL-23 receptor. Icotrokinra inhibits IL-23-induced STAT3 phosphorylation in peripheral blood mononuclear cells (IC₅₀=5.6 pM) and inhibits IL-23-induced interferon IFN-γ production in NK cells with an IC₅₀ of 18.4 pM. In addition, Icotrokinra exhibits anti-inflammatory activity in a rat TNBS-induced colitis model. Icotrokinra can be used in the study of psoriasis, psoriatic arthritis, and inflammatory bowel disease .

HY-P10935A

Amilo-5MER TFA 5-MP TFA	Amyloid-β Interleukin Related	Inflammation/Immunology
Amilo-5MER (5-MP) TFA is an orally active and selective Serum Amyloid A (SAA) inhibitor. Amilo-5MER TFA specifically inhibits the release of pro-inflammatory cytokines IL-6 and IL-1β from SAA-activated cells. Amilo-5MER TFA reduces chronic inflammation and relieves symptoms of diseases such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and multiple sclerosis (MS). Amilo-5MER TFA is promising for research of autoimmune diseases and chronic inflammatory diseases .

HY-106268A

Larazotide acetate 4 Publications Verification	Gap Junction Protein	Inflammation/Immunology
Larazotide acetate is a peptide which is an orally active zonulin antagonist. Larazotide acetate shows antiviral activity to varicella-zoster virus (VZV) with EC₅₀s of 44.14 and 59.06 μM for strain OKA and 07-1, respectively. Larazotide acetate can be used for the research of celiac disease and infection.

HY-106268

Larazotide 4 Publications Verification	Gap Junction Protein	Infection Inflammation/Immunology
Larazotideis a peptide which is an orally active zonulin antagonist. Larazotide shows antiviral activity to varicella-zoster virus (VZV) with EC₅₀s of 44.14 and 59.06 μM for strain OKA and 07-1, respectively. Larazotide can be used for the research of celiac disease and infection .

HY-148195

Ercanetide NNZ-2591	Biochemical Assay Reagents	Neurological Disease
Ercanetide (NNZ 2591) is a synthetic analogue of a small peptide of cyclic glycine proline (cGP). Ercanetide shows orally active and cross the blood-brain barrier. Ercanetide shows neuroprotective after ischemic brain injury. NNZ 2591 improves motor function in a rat model of Parkinson's disease. Ercanetide has the potential for the research of ischemic brain injury and angelman syndrome .

HY-P11111

QP5	Drug Derivative	Others
QP5 is an Amelogenin (HY-P71627)-derived peptide. QP5 binds on the hydroxyapatite and demineralized tooth enamel surfaces, transitorily stabilize the amorphous calcium phosphate (ACP), control the crystallization of hydroxyapatite and promote the remineralization of caries lesions. QP5 promotes remineralization in rat caries models. QP5 can be used for oral diseases like dental caries research .

HY-P10935

Amilo-5MER 5-MP	Amyloid-β Interleukin Related	Inflammation/Immunology
Amilo-5MER (5-MP) is an orally active and selective Serum Amyloid A (SAA) inhibitor. Amilo-5MER specifically inhibits the release of pro-inflammatory cytokines IL-6 and IL-1β from SAA-activated cells. Amilo-5MER reduces chronic inflammation and relieves symptoms of diseases such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and multiple sclerosis (MS). Amilo-5MER is promising for research of autoimmune diseases and chronic inflammatory diseases .

HY-P10861

RI-AG03	Tau Protein	Neurological Disease
RI-AG03 is an orally active and a BBB-penetrable Tau aggregation peptide inhibitor. RI-AG03 inhibits Tau aggregation and improves associated neurodegeneration and behavioral phenotypes in both in vivo and in vitro models. RI-AG03 can be used in the study of tauopathies such as Alzheimer's disease .

HY-14614D

S-Adenosyl-L-methionine iodide Maximum Cited Publications 13 Publications Verification S-Adenosyl methionine iodide; Ademetionine iodide; AdoMet iodide	Endogenous Metabolite Apoptosis	Neurological Disease Inflammation/Immunology Cancer
S-Adenosyl-L-methionine (S-Adenosyl methionine) iodide is an orally active methyl group donor. S-Adenosyl-L-methionine iodide is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine iodide also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine iodide has the potential for, cancer, liver disease and osteoarthritis research .

HY-121705

Propionyl-L-carnitine	Endogenous Metabolite Apoptosis Bcl-2 Family NF-κB Survivin Src Akt AMPK NO Synthase	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Propionyl-L-carnitine is an orally active L-carnitine derivative. Propionyl-L-carnitine has a high affinity for muscle L-carnitine transferase. Propionyl-L-carnitine increases Apoptosis, Bax, and reduces NF-κB, VCAM-1, MCP-1, and survivin. Propionyl-L-carnitine activates Src kinase, Akt, induces p-AMPK and nitric oxide synthesis. Propionyl-L-carnitine alleviates cardiovascular disease, obesity, and colitis .

HY-P10056

HEP-1 Human ezrin peptide (324-337)	HIV HCV HPV Influenza Virus Interleukin Related	Infection Inflammation/Immunology
HEP-1 (Human ezrin peptide (324 - 337)) is an orally active peptide with antiviral, anti-inflammatory, and immunomodulatory activities. HEP-1 is effective against infections by various viruses such as HIV, HCV, herpes viruses, HPV, and influenza viruses. As an immunomodulator, HEP-1 can enhance the adaptive immunity mediated by B cells and T cells. HEP-1 can also increase the antibody titers after hepatitis B vaccination. HEP-1 can be used in the research of viral infections and inflammation-related diseases .

HY-P1633

Protegrin-1 PG1	Bacterial ERK COX NF-κB Apoptosis NO Synthase Dengue Virus	Infection Inflammation/Immunology
Protegrin-1 is an orally active antibacterial peptide. Protegrin-1 activates ERK, COX2, NFκB, inhibits Apoptosis, and NO production. Protegrin-1 has antibacterial activity against S. aureus, E. faecium, E. coli, P. aeruginosa and K. Pneumoniae, with MBC values between 10 and 20 µM. Protegrin-1 has antiviral activity against dengue NS2B-NS3. Protegrin-1 has anti-inflammatory activity. Protegrin-1 is used in the study of inflammatory diseases and infections .

HY-P1130

M871 Galanin-(2-13)-Glu-His-(Pro)3-(Ala-Leu)2-Ala-amide	Neuropeptide Y Receptor	Cardiovascular Disease Neurological Disease Inflammation/Immunology Endocrinology Cancer
M871 (Galanin-(2-13)-Glu-His-(Pro)3-(Ala-Leu)2-Ala-amide) is an orally active and selective galanin receptor type 2 (GalR2) antagonist. M871 exhibits K_i values of 13.1 nM, 420 nM and >10 μM for GalR2, GalR1 and GalR3 respectively. M871 relieves the mice allergic rhinitis by reducing IgE production, as well as the number of B cells in tissues. M871 can inhibit the nerve invasion of salivary adenoid cystic carcinoma (SACC) and alleviate myocardial ischemia-reperfusion injury. M871 can be used for research on GalR2-related diseases (such as epilepsy, pain) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-128442

Phenyl sulfate Phenyl hydrogen sulfate	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Phenyl sulfate is an orally active gut microbiota-derived metabolite. Phenyl sulfate induces albuminuria and podocyte damage in experimental models of diabetes. Phenyl sulfate can be used as a disease marker and future therapeutic target in diabetic kidney disease .

HY-N7560

Safranal 5 Publications Verification	Structural Classification Ketones, Aldehydes, Acids Source classification Lridaceae Plants Crocus sativus L.	Keap1-Nrf2
Safranal is an orally active main component of Saffron (Crocus sativus) and is responsible for the unique aroma of this spice. Safranal has neuroprotective and anti-inflammatory effects and has the potential for Parkinson’s disease research .

HY-A0027

Fenspiride hydrochloride	Classification of Application Fields Disease Research Fields Endocrinology	Histamine Receptor Phosphodiesterase (PDE)
Fenspiride, an orally active non-steroidal antiinflammatory agent, is an antagonist of H1-histamine receptor. Fenspiride inhibites phosphodiesterase 3 (PDE3), phosphodiesterase 4 (PDE4) and phosphodiesterase 5 (PDE5) activities with -log IC₅₀ values of 3.44, 4.16 and approximately 3.8, respectively. Fenspiride can be used for the research of respiratory diseases .

HY-124344

Avenanthramide C	Structural Classification Simple Phenylpropanols Avena sativa Linn. Gramineae Source classification Phenylpropanoids Plants	Interleukin Related
Avenanthramide C is an orally active avenanthramide that can be isolated from oat seeds. Avenanthramide C decreases the protein expression of cleaved caspase-3 and increases the expression of p-GSK3β(Ser9) and IL-10 levels. Avenanthramide C has the potential for the research of Alzheimer’s disease .

HY-B1804

Tricaprilin Trioctanoin; Glyceryl trioctanoate	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Tricaprilin (Trioctanoin) is an orally active and well tolerated ketogenic agent that safely induces ketosis. Tricaprilin restores brain electrical activity and metabolism to help counteract neuroinflammation in migraine. Tricaprilin is promising for research of migraine prevention and Alzheimer’s disease (AD). Tricaprilin is a pure C8 medium chain triglyceride (MCT) .

HY-N15719

Dipsacus saponin R	Triterpenes Structural Classification Polysaccharides Terpenoids Dipsacaceae Source classification Dipsacus asper Plants Saccharides	Others
Dipsacus saponin R (Compound 1) is an orally active triterpenoid saponin found in Radix Dipsaci. Dipsacus saponin R promotes bone formation and repair by regulating osteoblast activity or inhibiting osteoclast function. Dipsacus saponin R is promising for research of bone diseases such as osteoporosis and fracture healing .

HY-128442R

Phenyl sulfate (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Source classification Endogenous metabolite	Endogenous Metabolite
Phenyl sulfate (Standard) is the analytical standard of Phenyl sulfate. This product is intended for research and analytical applications. Phenyl sulfate is an orally active gut microbiota-derived metabolite. Phenyl sulfate induces albuminuria and podocyte damage in experimental models of diabetes. Phenyl sulfate can be used as a disease marker and future therapeutic target in diabetic kidney disease .

HY-N7560R

Safranal (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Lridaceae Plants Crocus sativus L.	Keap1-Nrf2 Reference Standards
Safranal (Standard) is an analytical standard for Safranal. This product is intended for research and analytical applications. Safranal is the main component of saffron (Crocus sativus), is orally active, and is the source of the spice's unique aroma. Safranal has neuroprotective and anti-inflammatory effects and has research potential for Parkinson's disease.

HY-13764A

dl-Tetrandrine	Structural Classification Alkaloids Source classification Stephania japonica var. discolor (Blume) Forman Plants Menispermaceae Alkaloid Dimers	Calcium Channel
dl-Tetrandrine is an orally active and brain-penetrant calcium channel blocker that inhibits voltage-dependent calcium channels. dl-Tetrandrine selectively blocks Ca ²⁺ influx with an IC₅₀ value of approximately 1-10 μM. dl-Tetrandrine exerts anti-inflammatory, immunosuppressive, and anti-arrhythmic activities by inhibiting intracellular calcium overload, and can reverse multidrug resistance in tumor cells. dl-Tetrandrine is promising for research of autoimmune diseases (such as rheumatoid arthritis), cardiovascular diseases, and tumor drug resistance reversal .

HY-N8563

Masticadienonic acid	Triterpenes Structural Classification Terpenoids Source classification Pistacia terebinthus L. Plants Anacardiaceae	p38 MAPK NF-κB Keap1-Nrf2
Masticadienonic acid is an orally active and selective inhibitor of MAPK (p38, ERK, JNK) and NF-κB pathways and an agonist of the Nrf2 pathway. Masticadienonic acid reduces the release of pro-inflammatory cytokines such as TNFα, IL-1β, and IL-6, restores the expression of intestinal tight junction proteins (ZO-1, occludin), and modulates gut microbiota. Masticadienonic acid is promising for research of inflammatory bowel disease .

HY-N15727

2,5-Dimethylchromone-7-O-β-D-glucopyranoside	Structural Classification Rheum australe D. Don Polygonaceae Source classification Plants Saccharides Monosaccharides	Others
2,5-Dimethylchromone-7-O-β-D-glucopyranoside is an orally active chromone glycoside found in the underground parts of Rheum australe. 2,5-Dimethylchromone-7-O-β-D-glucopyranoside shows a DPPH radical scavenging activity with an IC₅₀ value of 66.9 μM. 2,5-Dimethylchromone-7-O-β-D-glucopyranoside scavenges free radicals by providing hydrogen atoms through phenolic hydroxyl groups, inhibiting lipid peroxidation. 2,5-Dimethylchromone-7-O-β-D-glucopyranoside is promising for research of oxidative stress-related diseases such as inflammation and skin diseases .

HY-126382

Hesperidin methylchalcone 1 Publications Verification	Chalcones Flavonoids Source classification Rutaceae Plants Citrus Inflammation/Immunology Disease Research Fields	NF-κB
Hesperidin methylchalcone (Hesperidin methyl chalcone) is an orally active flavonoid that has analgesic, anti-inflammatory and antioxidant properties. Hesperidin methylchalcone exhibits vasoprotective activity. Hesperidin methylchalcone inhibits oxidative stress, cytokine production and NF-κB activation. Hesperidin methylchalcone can be used for the research of gout disease .

HY-N15190

Sesaminol	Structural Classification Acanthaceae Source classification Lignans Justicia procumbens Linnaeus Phenylpropanoids Plants	Quinone Reductase Keap1-Nrf2 Reactive Oxygen Species (ROS)
Sesaminol is an orally active activator for Nrf2-ARE pathway, that promotes the the nuclear translocation of Nrf2 and enhances the NQO1 expression, thereby enhances the cell's defense against oxidative stress. Sesaminol inhibits 6-OHDA (HY-B1081)-induced ROS production and apoptosis in cell SH-SY5Y. Sesaminol exhibits neuroprotective efficacy against Rotenone (HY-B1756)-induced Parkinson's disease .

HY-126382R

Hesperidin methylchalcone (Standard)	Chalcones Flavonoids Source classification Rutaceae Plants Citrus	NF-κB
Hesperidin methylchalcone (Standard) is the analytical standard of Hesperidin methylchalcone. This product is intended for research and analytical applications. Hesperidin methylchalcone (Hesperidin methyl chalcone) is an orally active flavonoid that has analgesic, anti-inflammatory and antioxidant properties. Hesperidin methylchalcone exhibits vasoprotective activity. Hesperidin methylchalcone inhibits oxidative stress, cytokine production and NF-κB activation. Hesperidin methylchalcone can be used for the research of gout disease .

HY-13771A

Ursodeoxycholic acid sodium 15+ Cited Publications Ursodeoxycholate sodium; Ursodiol sodium; UCDA sodium	Structural Classification Microorganisms Classification of Application Fields Source classification Metabolic Disease Inflammation/Immunology Disease Research Fields Steroids	G protein-coupled Bile Acid Receptor 1 FXR Endogenous Metabolite
Ursodeoxycholic acid (Ursodeoxycholate) sodium is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid sodium acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid sodium can be used for the research of a variety of hepatic and gastrointestinal diseases. Orally active .

HY-13771

Ursodeoxycholic acid 15+ Cited Publications Ursodeoxycholate; Ursodiol; UDCA	Structural Classification Human Gut Microbiota Metabolites Other disease Classification of Application Fields Source classification Disease markers Endogenous metabolite Disease Research Fields Steroids Cancer	G protein-coupled Bile Acid Receptor 1 FXR Angiotensin-converting Enzyme (ACE) Endogenous Metabolite
Ursodeoxycholic acid (Ursodeoxycholate) is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid can be used for the research of a variety of hepatic and gastrointestinal diseases. Ursodeoxycholic acid also reduces ACE2 expression and is beneficial for reducing SARS-CoV-2 infection. Orally active .

HY-13771R

Ursodeoxycholic acid (Standard) Ursodeoxycholate (Standard); Ursodiol (Standard); UDCA (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Other disease Source classification Disease markers Endogenous metabolite Steroids	Reference Standards G protein-coupled Bile Acid Receptor 1 FXR Angiotensin-converting Enzyme (ACE) Endogenous Metabolite
Ursodeoxycholic acid (Standard) is the analytical standard of Ursodeoxycholic acid. This product is intended for research and analytical applications. Ursodeoxycholic acid (Ursodeoxycholate) is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid can be used for the research of a variety of hepatic and gastrointestinal diseases. Ursodeoxycholic acid also reduces ACE2 expression and is beneficial for reducing SARS-CoV-2 infection. Orally active .

HY-N11286

Tridocosahexaenoylglycerol TG-DHA; Meganol D	Structural Classification Natural Products Animals Source classification	Others
Tridocosahexaenoylglycerol (TG-DHA) is an orally active dietary supplement that improves autoimmune encephalomyelitis in mice. Tridocosahexaenoylglycerol shows beneficial effects on neurodegenerative diseases and also improves macular function in diabetic retinopathy. Tridocosahexaenoylglycerol can be used for research on neurological diseases, inflammatory immune diseases, and metabolic diseases .

HY-N7204

4-Hydroxyderricin 1 Publications Verification	Structural Classification Chalcones Monophenols Flavonoids Phenols Umbelliferae Plants Ondetia linearis Benth.	Monoamine Oxidase Dopamine β-hydroxylase Apoptosis
4-Hydroxyderricin, the major active ingredients of Angelica keiskei Koidzumi, is an orally active, potent selective MAO-B (Monoamine oxidase inhibitors) inhibitor with an IC₅₀ of 3.43 μM. 4-Hydroxyderricin also mildly inhibits dopamine β (DBH)-hydroxylase activity. 4-Hydroxyderricin has antidepressant activity, anti-allergic, anti-diabetic, anti-oxidant, and antitumor effects. 4-Hydroxyderricin promotes apoptosis and cell cycle arrest through regulating PI3K/AKT/mTOR pathway in hepatocellular cells. 4-Hydroxyderricin inhibits osteoclast formation and accelerates osteoblast differentiation . 4-Hydroxyderricin is promising for research of inflammatory diseases .

HY-70037

Cinacalcet 15+ Cited Publications AMG 073	Cardiovascular Disease Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	CaSR Endogenous Metabolite
Cinacalcet (AMG 073) is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease research.

HY-70037A

Cinacalcet hydrochloride 15+ Cited Publications AMG-073 hydrochloride	Cardiovascular Disease Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	CaSR Endogenous Metabolite
Cinacalcet hydrochloride (AMG-073 hydrochloride) is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease treatment.

HY-59291

Levacetylleucine N-Acetyl-L-leucine	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Amino Acid Derivatives
Levacetylleucine (N-acetyl-L-leucine), an orally bioavailable and brain-penetrant compound, is an acetylated derivative of amino acid Leucine. Levacetylleucine is the active form of N-acetyl-leucine (NAL). Levacetylleucine attenuates neuronal death and neuroinflammation in the cortical tissue of mice. Levacetylleucine also potentially improves ameliorates lysosomal and metabolic dysfunction. Levacetylleucine improves compensation of postural symptoms after unilateral chemical labyrinthectomy (UL) in rats. Levacetylleucine is promising for research of neurological manifestations of Niemann-Pick disease type C, traumatic brain injury and neurodegeneration prevention .

HY-124073

Dihydrocapsiate	Structural Classification Monophenols Capsicum annuum L. Classification of Application Fields Source classification Phenols Metabolic Disease Plants Solanaceae Disease Research Fields	TRP Channel
Dihydrocapsiate, as a compound of capsinoid family, is an orally active TRPV1 agonist. Dihydrocapsiate can be used for the research of metabolism disease .

HY-N11286R

Tridocosahexaenoylglycerol (Standard) TG-DHA (Standard); Meganol D (Standard)	Structural Classification Natural Products Animals Source classification	Reference Standards Others
Tridocosahexaenoylglycerol (Standard) is the analytical standard of Tridocosahexaenoylglycerol. This product is intended for research and analytical applications. Tridocosahexaenoylglycerol (TG-DHA) is an orally active dietary supplement that improves autoimmune encephalomyelitis in mice. Tridocosahexaenoylglycerol shows beneficial effects on neurodegenerative diseases and also improves macular function in diabetic retinopathy. Tridocosahexaenoylglycerol can be used for research on neurological diseases, inflammatory immune diseases, and metabolic diseases .

HY-N4173

8-Oxoepiberberine	Structural Classification other families Stilbenes Classification of Application Fields Source classification Metabolic Disease Plants Disease Research Fields	Drug Metabolite
8-Oxoepiberberine is an alkaloid metabolite in the plasma after oral administration of Zuojin formula, a traditional chinese medicine used to treat gastrointestinal disease .

HY-N2526R

Nervonic acid (Standard) Selacholeic acid (Standard); cis-15-Tetracosenoic acid (Standard)	Structural Classification Microorganisms other families Ketones, Aldehydes, Acids Source classification Disease markers Endocrine diseases Plants Endogenous metabolite	Reference Standards Endogenous Metabolite NF-κB
Nervonic acid (Standard) is the analytical standard of Nervonic acid. This product is intended for research and analytical applications. Nervonic acid is a monounsaturated fatty acid with oral activity. Nervonic acid exerts anti-inflammatory activity by inhibiting NF-κB signaling. Nervonic acid can be used in the study of neurodegenerative diseases[1][2][3].

HY-N2518

Agnuside Agnoside	Structural Classification Monophenols other families Iridoids Classification of Application Fields Terpenoids Source classification Phenols Plants Disease Research Fields Endocrinology	NO Synthase COX Caspase HIF/HIF Prolyl-Hydroxylase ASCT
Agnuside is used in the study of asthma, inflammation, and angiogenic diseases. Agnuside is an orally active compound that can be extracted from Vitex negundo .

HY-W004284

Heptadecanoic acid 2 Publications Verification	Cardiovascular Disease Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Apoptosis PI3K Akt
Heptadecanoic acid is an odd-chain saturated fatty acid (OCS-FA) with oral activity. Heptadecanoic acid can inhibit cell proliferation and induce Apoptosis. Heptadecanoic acid has antitumor activity. Heptadecanoic acid is associated with a number of diseases, including coronary heart disease, pre-diabetes and type 2 diabetes, and multiple sclerosis .

HY-W006405

Isoflavone	Structural Classification Flavonoids Classification of Application Fields Leguminosae Glycine max (L.) merr Source classification Other Diseases Plants Disease Research Fields Isoflavones	Estrogen Receptor/ERR
Isoflavone is an orally available bioactive component of soy phytoestrogen with lipid-lowering and antioxidant activities. Isoflavone prevents a variety of chronic diseases by regulating fatty acid oxidation in the liver and gene expression in adipose tissue. In addition, isoflavone has important value in the research of cancer and cardiovascular diseases .

HY-N8630

Oleacein	Structural Classification Oleaceae Source classification Phenols Polyphenols Jasminum azoricum L. Plants	Angiotensin-converting Enzyme (ACE)
Oleacein (Compound 9) is an ACE inhibitor that can be isolated from J. grandiflorum. Oleacein is orally active and can be used in the study of metabolic and cardiovascular diseases .

HY-130750

Phycocyanobilin	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Reactive Oxygen Species (ROS)
Phycocyanobilin, an orally active antioxidative agent, is an effective scavenger for various reactive oxygen species. Phycocyanobilin can be used for the research of Alzheimer’s disease .

HY-N2440

Gypenoside A 1 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Cucurbitaceae Metabolic Disease Plants Gynostemma pentaphyllum (Thunb.) Makino Disease Research Fields	Interleukin Related Reactive Oxygen Species (ROS) AMPK FOXO COX Apoptosis
Gypenoside A is an orally active triterpenoid compound that can be isolated from Gynostemma pentaphyllum. Gypenoside A has anti-inflammatory and antioxidant activities. Gypenoside A also has a certain protective effect on cardiomyocytes and can inhibit apoptosis. Gypenoside A can be used in the research of cardiovascular diseases and inflammation-related diseases .

HY-N2526

Nervonic acid 5 Publications Verification Selacholeic acid; cis-15-Tetracosenoic acid	Structural Classification Microorganisms other families Ketones, Aldehydes, Acids Source classification Disease markers Endocrine diseases Plants Endogenous metabolite	Endogenous Metabolite NF-κB
Nervonic acid is a monounsaturated fatty acid with oral activity. Nervonic acid exerts anti-inflammatory activity by inhibiting NF-κB signaling. Nervonic acid can be used in the study of neurodegenerative diseases .

HY-N0568

Madecassoside 1 Publications Verification Asiaticoside A	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Other Diseases Tagetes lucida Cav. Umbelliferae Plants Endogenous metabolite Disease Research Fields	Endogenous Metabolite Apoptosis Autophagy Keap1-Nrf2 p38 MAPK Caspase
Madecassoside is a pentacyclic triterpene isolated from Centella asiatica and has anti-inflammatory properties. Antioxidant and anti-aging effects. Madecassoside is a pentacyclic triterpene isolated from Centella asiatica. Madecassoside is orally active and has inhibitory properties against inflammation, oxidation, apoptosis and autophagy. Madecassosid inhibits activities of p38 MAPK and NF-kB ^[5][6], exhibits an anti-apopototic property, activates Nrf2 expression to reduce the neurotoxicity . Madecassoside can be used in endocrine diseases, cardiovascular diseases, skin diseases and other diseases.

HY-70037R

Cinacalcet (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	CaSR Endogenous Metabolite
Cinacalcet (Standard) is the analytical standard of Cinacalcet. This product is intended for research and analytical applications. Cinacalcet (AMG 073) is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease research.

HY-D0803

Thymoquinone 5+ Cited Publications	Quinones Structural Classification Classification of Application Fields Nigella sativa L. Ranunculaceae Benzene Quinones Plants Inflammation/Immunology Disease Research Fields	Apoptosis VEGFR PI3K Akt
Thymoquinone is an orally active natural product isolated from N. sativa Thymoquinone down-regulates the VEGFR2-PI3K-Akt pathway. Thymoquinone has antioxidant, anti-inflammatory, anticancer, antiviral, anticonvulsant, antifungal, antiviral, antiangiogenic activity and hepatoprotective effects. Thymoquinone can be used to study Alzheimer's disease, cancer, cardiovascular disease, infectious disease and inflammation .

HY-B0715

Pentoxifylline 5+ Cited Publications BL-191; PTX; Oxpentifylline	Classification of Application Fields Disease Research Fields Cancer	Phosphodiesterase (PDE) Autophagy HIV
Pentoxifylline (BL-191), a haemorheological agent, is an orally active non-selective phosphodiesterase (PDE) inhibitor, with immune modulation, anti-inflammatory, hemorheological, anti-fibrinolytic and anti-proliferation effects. Pentoxifylline can be used for the research of peripheral vascular disease, cerebrovascular disease and a number of other conditions involving a defective regional microcirculation .

HY-16482

Teglicar 3 Publications Verification	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Other Alkaloids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Teglicar is a selective and reversible orally active liver isoform of carnitine palmitoyl-transferase 1 (L-CPT1) inhibitor with an IC₅₀ value of 0.68 μM and a K_i value of 0.36 μM. Teglicar has a potential antihyperglycemic propert. Teglicar can be used for the research of diabetes and neurodegenerative disease including Huntington's disease (HD) .

HY-B1028

Pantethine 3 Publications Verification D-Pantethine; LBF disulfide	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite SARS-CoV
Pantethine is an orally active lipid-lowering agent. Pantethine has anti-tumor, anti-inflammatory and anti-SARS-COV virus activities. Pantethine is also a neuroprotective agent. Pantethine can be used in the study of Alzheimer's disease, Parkinson's disease, major depression, systemic sclerosis and pantothenate kinase-related neurodegeneration .

HY-N4195

Resveratroloside 2 Publications Verification Resveratrol glycoside; trans-Resveratrol 4'-O-β-D-glucopyranoside	Cardiovascular Disease Structural Classification Stilbenes Classification of Application Fields Polygonaceae Reynoutria japonica Houtt. Source classification Phenols Polyphenols Plants Disease Research Fields	Glycosidase
Resveratroloside (Resveratrol glycoside) is an orally active competitive inhibitor of α-glucosidase. Resveratroloside has hypoglycemic and cardioprotective effects. Resveratroloside can be used for the research of diabetes and heart system diseases .

HY-70037AR

Cinacalcet hydrochloride (Standard) AMG-073 hydrochloride (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Reference Standards CaSR Endogenous Metabolite
Cinacalcet (hydrochloride) (Standard) is the analytical standard of Cinacalcet (hydrochloride). This product is intended for research and analytical applications. Cinacalcet hydrochloride (AMG-073 hydrochloride) is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease treatment.

HY-W327449

Feruloylputrescine	Structural Classification Monophenols Gramineae Source classification Phenols Oryza sativa L. Plants	Cytochrome P450
Feruloylputrescine is an oral active phenolamide found in citrus plants and formed through the decarboxylation of L-Arginine. Feruloylputrescine inhibits monooxygenase (cntA) and reductase (cntB) and trimethylamine production. Feruloylputrescine can be used for cardiovascular diseases research .

HY-N2905

Aurantiamide acetate 1 Publications Verification Asperglaucide	Structural Classification Natural Products Portulacaceae Classification of Application Fields Source classification Portulaca oleracea Linn. Plants Inflammation/Immunology Disease Research Fields	Cathepsin
Aurantiamide acetate (TMC-58A) is a selective and orally active cathepsin inhibitor isolated from Portulaca oleracea L. Aurantiamide acetate has anti-inflammatory activities and can be used for the study of inflammatory diseases .

HY-124073R

Dihydrocapsiate (Standard)	Structural Classification Monophenols Capsicum annuum L. Source classification Phenols Solanaceae Plants	Reference Standards TRP Channel
Dihydrocapsiate (Standard) is the analytical standard of Dihydrocapsiate. This product is intended for research and analytical applications. Dihydrocapsiate, as a compound of capsinoid family, is an orally active TRPV1 agonist. Dihydrocapsiate can be used for the research of metabolism disease .

HY-N2127

Pinostrobin 1 Publications Verification	Structural Classification Monophenols Flavonoids other families Classification of Application Fields Flavonones Source classification Phenols Plants Inflammation/Immunology Disease Research Fields	Amyloid-β Apoptosis Ser/Thr Protease HSV Interleukin Related
Pinostrobin is a flavonoid with anti-cancer, antioxidant, antiviral and neuroprotective activities. Pinostrobin has oral activity. Pinostrobin is a potent PCSK9 inhibitor that inhibits the catalytic activity of PCSK9. Pinostrobin can be used in the research of viral infections, cancer, leukemia, cardiovascular and cerebrovascular diseases, cirrhosis, inflammation and neurological diseases .

HY-32350

Ercalcitriol 3 Publications Verification 1α,25-Dihydroxy Vitamin D2	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	VD/VDR Drug Metabolite Endogenous Metabolite
Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is a vitamin D receptor (VDR) agonist with high binding affinity. After binding to VDR, Ercalcitriol forms a complex with retinoid X receptor (RXR) to regulate target gene transcription. For example, Ercalcitriol induces human gingival/oral epithelial cells to produce human cat antimicrobial peptide (hCAP-18/LL-37), which has antimicrobial activity against periodontal pathogens such as Porphyromonas gingivalis. Ercalcitriol enhances the innate immune defense of the oral mucosa by promoting the expression of antimicrobial peptides, and is mainly used in the study of periodontal diseases and immune-related oral diseases .

HY-N1132R

D-(+)-Trehalose (Standard) D-Trehalose (Standard); α,α-Trehalose (Standard)	Structural Classification Polysaccharides Source classification Endogenous metabolite Saccharides	Reference Standards Endogenous Metabolite
Etamivan (Standard) is the analytical standard of Etamivan. This product is intended for research and analytical applications. Etamivan (Ethamivan), an orally active respiratory stimulant, is mainly used in the research of barbiturate overdose and chronic obstructive pulmonary disease .

HY-W010041

Scyllo-Inositol	Structural Classification Natural Products Source classification Endogenous metabolite	α-synuclein Amyloid-β
Scyllo-Inositol is an inhibitor that targets the aggregation of misfolded proteins (such as α-synuclein and Amyloid-β), is orally effective, and can cross the blood-brain barrier. Scyllo-Inositol can selectively bind to and stabilize non-toxic oligomers, preventing them from converting into toxic fibers, exerting protein homeostasis regulation and neuroprotective activity. Scyllo-Inositol binds to the hydrophobic region of pathogenic proteins, inhibits protein aggregation, and promotes lysosome- and proteasome-mediated degradation pathways, thereby reducing neurotoxicity. Scyllo-Inositol can be used in the study of neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, and Huntington's disease .

HY-N2581

Phytic acid sodium salt 1 Publications Verification myo-Inositol, hexakis(dihydrogen phosphate) sodium salt; Inositol hexaphosphate sodium salt	Structural Classification Natural Products Zea mays L. Classification of Application Fields Gramineae Source classification Other Diseases Plants Disease Research Fields	Endogenous Metabolite Amyloid-β Autophagy
Phytic acid sodium salt (myo-Inositol; hexakis dihydrogen phosphate; Inositol hexaphosphate) is an orally active compound derived from the seeds of legumes. Phytic acid sodium salt is a [PO4] ³- storage depot and precursor for other inositol phosphates and pyrophosphates. phytic acid is hydrolyzed by phytases in a stepwise manner in the plant. Phytic acid sodium salt attenuates Aβ oligomers and upregulates autophagy protein. Phytic acid sodium salt can be used in cardiovascular disease, metabolic disease, nervous system disease and cancer research .

HY-W004284R

Heptadecanoic acid (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Reference Standards Apoptosis PI3K Akt
Heptadecanoic acid (Standard) is the analytical standard of Heptadecanoic acid. This product is intended for research and analytical applications. Heptadecanoic acid is an odd-chain saturated fatty acid (OCS-FA) with oral activity. Heptadecanoic acid can inhibit cell proliferation and induce Apoptosis. Heptadecanoic acid has antitumor activity. Heptadecanoic acid is associated with a number of diseases, including coronary heart disease, pre-diabetes and type 2 diabetes, and multiple sclerosis[1].

Cat. No.	Product Name	Chemical Structure

HY-19883S

Lusutrombopag-d13
Lusutrombopag-d₁₃ is deuterium labeled Lusutrombopag. Lusutrombopag is an orally bioavailable thrombopoietin (TPO) receptor agonist, used for treatment of chronic liver disease.

HY-70037AS

Cinacalcet-d3 hydrochloride
Cinacalcet-d₃ (hydrochloride) is the deuterium labeled Cinacalcet (hydrochloride). Cinacalcet hydrochloride (AMG-073 hydrochloride) is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease treatment.

HY-B0715S

Pentoxifylline-d6

Pentoxifylline-d₆ is the deuterium labeled Pentoxifylline. Pentoxifylline (BL-191), a haemorheological agent, is an orally active non-selective phosphodiesterase (PDE) inhibitor, with immune modulation, anti-inflammatory, hemorheological, anti-fibrinolytic and anti-proliferation effects. Pentoxifylline can be used for the research of peripheral vascular disease, cerebrovascular disease and a number of other conditions involving a defective regional microcirculation .

HY-B0715S2

Pentoxifylline-d5

Pentoxifylline-d₅ is the deuterium labeled Pentoxifylline. Pentoxifylline (BL-191), a haemorheological agent, is an orally active non-selective phosphodiesterase (PDE) inhibitor, with immune modulation, anti-inflammatory, hemorheological, anti-fibrinolytic and anti-proliferation effects. Pentoxifylline can be used for the research of peripheral vascular disease, cerebrovascular disease and a number of other conditions involving a defective regional microcirculation .

HY-177130S

Socrodeucitinib

Socrodeucitinib (Compound Example 58) is an orally active and selective tyrosine kinase 2 (TYK2) inhibitor with an IC₅₀ value of 1.41 nM. Socrodeucitinib exerts anti-inflammatory activity by inhibiting TYK2-mediated cytokine signaling pathways and reducing the secretion of inflammatory factors. Socrodeucitinib is promising for research of autoimmune diseases such as psoriasis and inflammatory diseases .

HY-17368S2

Rivastigmine-d3 hydrochloride

Rivastigmine-d₃ hydrochloride is deuterated labeled Rivastigmine (HY-17368). Rivastigmine (ENA 713 free base) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC₅₀s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease .

HY-70037S

Cinacalcet-D3
Cinacalcet-d₃ is the deuterium labeled Cinacalcet. Cinacalcet (AMG 073) is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease treatment.

HY-Z3421S

Vonoprazan-d3 fumarate

Vonoprazan-d₃ fumarate is the deuterium labeled Vonoprazan fumarate (HY-15295). Vonoprazan Fumarate (TAK-438), a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan Fumarate inhibits H+,K+-ATPase activity in porcine gastric microsomes with an IC50 of 19 nM at pH 6.5. Vonoprazan Fumarate is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease .

HY-B0419S

Manidipine-d4

Manidipine-d₄ is the deuterium labeled Manidipine (HY-B0419). Manidipine is an orally active calcium channel antagonist. Manidipine regulates the expression of cytokines (IL-1β, IL-6). Manidipine has a hypotensive effect. Manidipine can be used in the study of cardiovascular diseases (such as hypertension, myocardial ischemia-reperfusion injury, ventricular hypertrophy), kidney diseases (such as glomerular diseases), and epilepsy .

HY-W020050S

Cystamine-d8 dihydrochloride

Cystamine-d₈ (dihydrochloride） is the deuterium labeled Cystamine (dihydrochloride） . Cystamine (dihydrochloride) is the disulfide form of the free thiol, cysteamine. Cystamine is an orally active transglutaminase (Tgase) inhibitor. Cystamine also has inhibition activity for caspase-3 with an IC₅₀ value of 23.6 μM. Cystamine can be used for the research of severals diseases including Huntington's disease (HD) .

HY-10888S

Istradefylline-13C,d3
Istradefylline- ¹³C,d₃ is the ¹³C- and deuterium labeled Istradefylline. Istradefylline is a very potent, selective and orally active adenosine A2A receptor antagonist with Ki of 2.2 nM in experimental models of Parkinson's disease.

HY-13720S

Pergolide-d7 hydrochloride
Pergolide-d₇ hydrochloride is deuterated labeled Pergolide (HY-13720). Pergolide (LY127809 (free base)) is an ergot-derived orally active dopamine receptor agonist. Pergolide can be used for Parkinson disease research .

HY-B0591S

Memantine-d3 hydrochloride
Memantine-d₃ (hydrochloride) is deuterium labeled Memantine. Memantine is an orally active, noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist. Memantine can be used for the research of moderate-to-severe Alzheimer's disease (AD) .

HY-W653978

Cinacalcet-d4 hydrochloride
Cinacalcet-d₄ (AMG-073-d₄) hydrochlorideis deuterium labeled Cinacalcet (hydrochloride). Cinacalcet hydrochloride (AMG-073 hydrochloride) is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease treatment .

HY-13720AS

Pergolide-d7 mesylate
Pergolide-d₇ (mesylate) is the deuterium labeled Pergolide mesylate. Pergolide mesylate (Pergolide methanesulfonate), an Ergoline derivative, is a potent and orally active dopamine D1 and D2 receptors agonist. Pergolide mesylate can be used for Parkinson's disease and hyperprolactinaemia research .

HY-B0966S

Dioxybenzone-d3

Dioxybenzone-d₃ is deuterium labeled Dioxybenzone. Dioxybenzone (Benzophenone-8; UV-24) is an organic compound used to block UVB and short-wave UVA (ultraviolet) radiation. Dioxybenzone has orally activity. Dioxybenzone exhibits estrogenic disrupting effect. Dioxybenzone up-regulates inflammatory cytokines. Dioxybenzone can be used for cancer, reproductive system disease and inflammatory disease study .

HY-B1028S

Pantethine-15N2

Pantethine- ¹⁵N₂ is the ¹⁵N₂ labeled Pantethine. Pantethine is an orally active lipid-lowering agent. Pantethine has anti-tumor, anti-inflammatory and anti-SARS-COV virus activities. Pantethine is also a neuroprotective agent. Pantethine can be used in the study of Alzheimer's disease, Parkinson's disease, major depression, systemic sclerosis and pantothenate kinase-related neurodegeneration .

HY-B1343AS

Pridinol-d5

Pridinol-d₅ is deuterium labeled Pridinol (HY-B1343A) . Pridinol is an orally active, blood-brain permeable, muscarinic acetylcholine receptor (mAChR)-directed muscle relaxant. Pridinol reduces the conduction of impulses to spinal motor neurons and exerts muscle relaxant activity. Pridinol inhibits skeletal muscle contractures in diseases of both central and peripheral origin and can be used in research in the field of musculoskeletal diseases .

HY-B1126S

Orphenadrine-d3 hydrochloride

Orphenadrine-d₃ (hydrochloride) is the deuterium labeled Orphenadrine hydrochloride . Orphenadrine hydrochloride is an orally active and non-competitive NMDA receptor antagonist (crosses the blood-brain barrier) with a K_i of 6.0 μM. Orphenadrine hydrochloride relieves stiffness, pain and discomfort due to muscle strains, sprains or other injuries. Orphenadrine hydrochloride is also used to relieve tremors associated with parkinson's disease. Orphenadrine citrate has good neuroprotective properties, can be used in studies of neurodegenerative diseases .

HY-B0247S

Torsemide-d7
Torsemide-d₇ is the deuterium labeled Torsemide. Torsemide (Torasemide) is an orally active loop diuretic. Torsemide has anti-aldosterone and vasodilatory effects. Torsemide also can be used for the research of heart failure, renal disease and hepatic cirrhosis .

HY-174267S

ATX-IN-2
ATX-IN-2 (Compound 25) is an orally active and potent ATX inhibitor with an IC₅₀ value of 3.27 nM. ATX-IN-2 reduces lysophosphatidic acid (LPA) secretion. ATX-IN-2 is promising for research of ATX-mediated diseases, such as inflammation, pulmonary fibrosis .

HY-W707693

Scyllo-Inositol-d6

Scyllo-Inositol-d₆ is the deuterium labeled Scyllo-Inositol (HY-W010041). Scyllo-Inositol is an inhibitor that targets the aggregation of misfolded proteins (such as α-synuclein and Amyloid-β), is orally effective, and can cross the blood-brain barrier. Scyllo-Inositol can selectively bind to and stabilize non-toxic oligomers, preventing them from converting into toxic fibers, exerting protein homeostasis regulation and neuroprotective activity. Scyllo-Inositol binds to the hydrophobic region of pathogenic proteins, inhibits protein aggregation, and promotes lysosome- and proteasome-mediated degradation pathways, thereby reducing neurotoxicity. Scyllo-Inositol can be used in the study of neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, and Huntington's disease .

HY-B0715S3

Pentoxifylline-d3

Pentoxifylline-d₃ (BL-191-d₃) is deuterium labeled Pentoxifylline. Pentoxifylline (BL-191), a haemorheological agent, is an orally active non-selective phosphodiesterase (PDE) inhibitor, with immune modulation, anti-inflammatory, hemorheological, anti-fibrinolytic and anti-proliferation effects. Pentoxifylline can be used for the research of peripheral vascular disease, cerebrovascular disease and a number of other conditions involving a defective regional microcirculation .

HY-W008614S1

Lansoprazole sulfone-13C6

Lansoprazole sulfone- ¹³C₆ (AG-1813- ¹³C₆) is ¹³C labeled Lansoprazole sulfone. Lansoprazole sulfone (AG-1813) is an orally active and selective inhibitor of H ⁺, K ⁺-ATPase. Lansoprazole sulfone can significantly stimulates gastric acid secretion by inhibiting H ⁺, K ⁺-ATPase. Lansoprazole sulfone has potential applications in duodenal ulcer, gastric ulcer, gastroesophageal reflux disease and Zolinger Ellison disease .

HY-111372S

Finerenone-d3

Finerenone-d3 is the deuterium labeled finerenone (HY-111372). Finerenone is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist (IC₅₀=18 nM). Finerenone displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (>500-fold). Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease .

HY-W008614S

Lansoprazole sulfone-d4

Lansoprazole sulfone-d₄ (AG-1813-d₄) is the deuterium labeled Lansoprazole sulfone. Lansoprazole sulfone-d₄ is an orally active and selective inhibitor of H ⁺, K ⁺-ATPase. Lansoprazole sulfone-d₄ can significantly stimulates gastric acid secretion by inhibiting H ⁺, K ⁺-ATPase. Lansoprazole sulfone-d₄ has potential applications in duodenal ulcer, gastric ulcer, gastroesophageal reflux disease and Zolinger Ellison disease .

HY-128393S1

Trilinolein-13C54

Trilinolein- ¹³C₅₄ is the ¹³C-labeled Trilinolein (HY-128393). Trilinolein is an orally active triglyceride that inhibits the PI3K/Akt, Ras/MEK/ERK signaling pathways, and MMP-2. Trilinolein can reduce oxidative stress, induce apoptosis, and inhibit cell migration. Trilinolein can be used in the research fields of cardiovascular disease, cerebrovascular disease (such as cerebral ischemia), and non-small cell lung cancer .

HY-111372S1

Finerenone-d5

Finerenone-d₅ (BAY 94-8862-d₅) is deuterium labeled Finerenone. Finerenone (BAY 94-8862) is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist (IC₅₀=18 nM). Finerenone displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (>500-fold). Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease .

HY-15728S

Radotinib-d6

Radotinib-d₆ is deuterium labeled Radotinib (HY-15728). Radotinib (IY-5511) is an orally active and BBB-permeable selective tyrosine kinase Bcr-Abl1 inhibitor with an IC₅₀ of 34 nM. Radotinib has anti-prion and anti-tumor activities. Radotinib can inhibit the proliferation, induce cell cycle arrest and apoptosis of tumor cells . Radotinib can be used in the research of cancer such as chronic myeloid leukemia and multiple myeloma, as well as neurodegenerative diseases such as prion diseases .

HY-17023S

Esomeprazole-d6 sodium
Esomeprazole-d₆ sodium is the deuterium labeled Esomeprazole. Esomeprazole ((S)-Omeprazole) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H ⁺, K ⁺-ATPase in gastric parietal cells. Esomeprazole has the potential for symptomatic gastroesophageal reflux disease research .

HY-17021S1

Esomeprazole-d3
Esomeprazole-d₃ is deuterium labeled Esomeprazole. Esomeprazole ((S)-Omeprazole) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H+, K+-ATPase in gastric parietal cells. Esomeprazole has the potential for symptomatic gastroesophageal reflux disease research .

HY-W010950S

Flecainide-d3
Flecainide-d₃ is the deuterium labeled Flecainide. Flecainide is an orally active antiarrhythmic agent. Flecainide can block sodium channels and inhibit calcium ion release mediated by the cardiac ryanodine receptor (RyR2). Flecainide can be used in the research of diseases such as catecholaminergic polymorphic ventricular tachycardia (CPVT) .

HY-17021S

Esomeprazole-d3 sodium
Esomeprazole-d₃ (sodium) is the deuterium labeled Esomeprazole. Esomeprazole ((S)-Omeprazole) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H+, K+-ATPase in gastric parietal cells. Esomeprazole has the potential for symptomatic gastroesophageal reflux disease research .

HY-119447S

Mavacoxib-d4
Mavacoxib-d₄ is the deuterium labeled Mavacoxib. Mavacoxib is a selective, oral long-acting cyclooxygenase-2 (COX-2) inhibitor and a long-acting non-steroidal anti-inflammatory drug (NSAID). Mavacoxib is used to treat pain and inflammation associated with degenerative joint disease in dogs .

HY-13593S

Chlorambucil-d8
Chlorambucil-d₈ is the deuterium labeled Chlorambucil. Chlorambucil (CB-1348), an orally active antineoplastic agent, is a bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin’s disease .

HY-B0357S

Diclazuril-d4
Diclazuril-d₄ is deuterium labeled Diclazuril. Diclazuril (R-64433), a benzeneacetonitrile derivative, is a potent and orally active anticoccidial agent. Diclazuril can be used for the research of certain infectious and parasitic diseases, including coccidiosis, acute toxoplasmosis, equine protozoal pyoencephalitis (EPM) et.al .

HY-100642S

3-O-Methyltolcapone-d7
3-O-Methyltolcapone-d₇ is a deuterium labeled 3-O-Methyltolcapone. 3-O-Methyltolcapone is a metabolite of Tolcapone. Tolcapone is an orally active, reversible, selective and potent COMT inhibitor. Tolcapone crosses the blood-brain barrier, and can be used for treatment of Parkinson's disease .

HY-13593S1

Chlorambucil-d8-1
Chlorambucil-d₈-1 is the deuterium labeled Chlorambucil. Chlorambucil (CB-1348), an orally active antineoplastic agent, is a bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin’s disease .

HY-17021S2

Esomeprazole-d3 potassium
Esomeprazole-d₃ potassium is deuterated labeled Esomeprazole (HY-17021). Esomeprazole ((S)-Omeprazole) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H ⁺, K ⁺-ATPase in gastric parietal cells. Esomeprazole has the potential for symptomatic gastroesophageal reflux disease research .

HY-N0304S2

L-DOPA-13C 1 Publications Verification
L-DOPA- ¹³C is the ¹³C labeled L-DOPA . L-DOPA (Levodopa) is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA can cross the blood-brain barrier and is converted into dopamine in the brain. L-DOPA has anti-allodynic effects and the potential for Parkinson's disease .

HY-N0304S

L-DOPA-d6
L-DOPA-d₆ is the deuterium labeled L-DOPA. L-DOPA (Levodopa) is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA can cross the blood-brain barrier and is converted into dopamine in the brain. L-DOPA has anti-allodynic effects and the potential for Parkinson's disease .

HY-B1018AS

Phenelzine-d5 sulfate

Phenelzine-d₅ sulfate is the deuterium labeled Phenelzine sulfate (HY-B1018A). Phenelzine sulfate, an antidepressant agent, is an irreversible and orally active monoamine oxidase (MAO-A and MAO-B) inhibitor. Phenelzine sulfate inhibits GABA transaminase and primary amine oxidase (PrAO), and sequester reactive aldehydes. Phenelzine sulfate also inhibits LSD1 (K_i: 5.6 μM) and suppresses oxidative stress and lipogenesis. Phenelzine sulfate elevates neurotransmitters (serotonin, norepinephrine, dopamine). Phenelzine sulfate is studied in neurological, metabolic and cancer diseases for depression and anxiety disorders, stroke, spinal cord injury, traumatic brain injury, multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, inflammatory pain, obesity and prostate cancer .

HY-W702966

Ethopabate-d5
Ethopabate-d₅ (Ethyl pabate-d₅) is the deuterium labeled Ethopabate (HY-B2138). Ethopabate (Ethyl pabate) is an orally active antiparasitic agent. Ethopabate is often used in combination with Amprolium hydrochloride (HY-B0937A) and others to prevent and treat poultry coccidiosis, leucosis, and other diseases .

HY-101277S1

Vadadustat-13C6
Vadadustat- ¹³C₆ (PG-1016548- ¹³C₆) is ¹³C labeled Vadadustat. Vadadustat (PG-1016548) is a titratable, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor . Vadadustat is an erythropoiesis-stimulating agent and has the potential for anemia treatment in chronic kidney disease in vivo .

HY-B0213S

Sulfameter-d4
Sulfameter-d₄ (Sulfametoxydiazine-d₄) is the deuterium labeled Sulfameter (HY-B0213) . Sulfameter (Sulfametoxydiazine) is an orally active long-acting sulfonamide antibiotic. Sulfameter is active against both Gram-positive and Gram-negative bacteria. Sulfameter can be used for the research of diseases such as respiratory and urinary tract infections .

HY-W756637

Ibufenac-13C6
Ibufenac- ¹³C₆ (Dytransin- ¹³C₆) is the ¹³C-labeled Ibufenac (HY-W040672). Ibufenac (Dytransin) is an orally active nonsteroidal anti-inflammatory agent. Ibufenac exerts anti-inflammatory, analgesic and antipyretic effects. Ibufenac is being studied for the treatment of rheumatic diseases such as rheumatoid arthritis .

HY-B0233S1

Isradipine-d6
Isradipine-d₆ is the deuterium labeled Isradipine . Isradipine (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease .

HY-N0304S1

L-DOPA-13C6
L-DOPA- ¹³C₆ is the ¹³C-labled L-DOPA . L-DOPA (Levodopa) is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA can cross the blood-brain barrier and is converted into dopamine in the brain. L-DOPA has anti-allodynic effects and the potential for Parkinson's disease .

HY-108411S

Emedastine-13C,d3 fumarate
Emedastine- ¹³C,d₃ fumarate is the ¹³C- and deuterium labeled Emedastine. Emedastine is an orally active, selective and high affinity histamine H1 receptor antagonist with a K_i value of 1.3 nM. Emedastine is a benzimidazole derivative with potent antiallergic properties and used for allergic rhinitis, allergic skin diseases and allergic conjunctivitis .

HY-100642S1

3-O-Methyltolcapone-d4
3-O-Methyltolcapone-d₄ is the deuterium labeled 3-O-Methyltolcapone. 3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone. Tolcapone is an orally active, reversible, selective and potent COMT inhibitor. Tolcapone crosses the blood-brain barrier, and can be used for treatment of Parkinson's disease .

Cat. No.	Product Name		Classification

HY-148191

CL-197		Alkynes
CL-197 is an orally active and long-acting purine anti-HIV nucleoside reverse transcriptase inhibitor (NRTI). CL-197 has potential effect on the research of viral, oncological and cerebrovascular diseases . CL-197 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-142035

N-Propargylglycine		Alkynes
N-Propargylglycine is an orally active irreversible inhibitor of proline dehydrogenase (PRODH). N-Propargylglycine has antitumor activity and can be used in the study of neurodegenerative diseases .

HY-10399A

Ladostigil hydrochloride TV-3326 hydrochloride		Alkynes
Ladostigil (TV-3326) hydrochloride is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO), with IC₅₀s of 37.1 and 31.8 μM for MAO-B and AChE, respectively. Ladostigil hydrochloride exhibits neuroprotective, antioxidant and anti-inflammatory activities. Ladostigil can be used for the research of depression and Alzheimer's disease . Ladostigil (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-16361A

Omigapil maleate CGP3466B; CGP3446 maleate; TCH346 maleate		Alkynes
Omigapil maleate, an orally bioavailable GAPDH nitrosylation inhibitor, abrogates Aβ_1-42-induced tau acetylation, memory impairment, and locomotor dysfunction in mice. Omigapil maleate has the potential for the research of Alzheimer's disease . Omigapil maleate (CGP3446B maleate) is a apoptosis inhibitor. Omigapil maleate can be used for the research of congenital muscular dystrophy (CMD) . Omigapil (maleate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-10400

Ladostigil hemitartrate TV-3326 hemitartrate		Alkynes
Ladostigil (TV-3326) hemitartrate is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO), with IC₅₀s of 37.1 and 31.8 μM for MAO-B and AChE, respectively. Ladostigil hemitartrate exhibits neuroprotective, antioxidant and anti-inflammatory activities. Ladostigil hemitartrate can be used for the research of depression and Alzheimer's disease . Ladostigil (hemitartrate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-B2091

Azidocillin		Azide
Azidocillin, a semi-synthetic Penicillin, is an orally active β-lactam antibiotic. Azidocillin bears an azide functionality and retains on-target activity within bacteria. Azidocillin can be used to research osteitis caused by dental surgery, otitis media, enterococcal septicemia and other bacterial infectious diseases . Azidocillin is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-131036

MAO-IN-M30 dihydrochloride		Alkynes
MAO-IN-M30 dihydrochloride is an orally active, brain-permeable, and brain selective irreversible MAO-A (IC₅₀=37 nM) and MAO-B (IC₅₀=57 nM) inhibitor. MAO-IN-M30 dihydrochloride is a potent iron chelator and radical scavenger. MAO-IN-M30 dihydrochloride has a neuroprotective effect against Dexamethasone-induced brain cell apoptosis. MAO-IN-M30 dihydrochloride also exhibits neurorestorative activity in post MPTP and lactacystin models of Parkinson's disease . MAO-IN-M30 (dihydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-146691

hMAO-B-IN-2		Alkynes
hMAO-B-IN-2 (compound 6j) is an orally active, potent, selective and BBB penetrated and competitive reversible hMAO-B inhibitor, with an IC₅₀ of 4 nM. hMAO-B-IN-2 shows low toxicity and good neuroprotective effects in SH-SY5Y cell. hMAO-B-IN-2 can be used for alzheimer’s disease research . hMAO-B-IN-2 is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-10399

Ladostigil TV-3326		Alkynes
Ladostigil (TV-3326) is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO), with IC₅₀s of 37.1 and 31.8 μM for MAO-B and AChE, respectively. Ladostigil exhibits neuroprotective, antioxidant and anti-inflammatory activities. Ladostigil can be used for the research of depression and Alzheimer's disease . Ladostigil is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-173115

15-LOX-IN-2		Alkynes
15-LOX-IN-2 (Compound 2a) is an orally active COX-2/15-LOX inhibitor and a partial agonist of PPARγ. 15-LOX-IN-2 has anti-inflammatory activity and inhibits the levels of 20-HETE, IL-1β and TNF-α in RAW 264.7 cells treated with LPS (HY-D1056). In addition, 15-LOX-IN-2 has significant glucose uptake capacity in the absence of insulin. 15-LOX-IN-2 can be used for the research of metabolic diseases .

Cat. No.	Product Name		Classification

HY-145721A

Mongersen sodium GED-0301 sodium		Antisense Oligonucleotides
Mongersen sodium is a specific and orally active SMAD7 antisense oligonucleotide. Mongersen sodium restores TGF-β1 activity leading to inhibition of inflammatory signals. Mongersen sodium can attenuate Crohn's disease-like experimental colitis in mice .

HY-N0131

Stigmasterol Maximum Cited Publications 8 Publications Verification		Cholesterol
Stigmasterol is an orally acitve, immunomodulatory agent with anti-inflammatory and neuroprotective effect, as well as able to cross the blood-brain barrier. Stigmasterol activates AMPK, which in turn inhibits NF-κB and NLRP3 signaling pathways, reduces microglia-mediated neuroinflammation, and alleviates cognitive impairment and Alzheimer's disease. Stigmasterol regulates M1/M2 polarization of microglia through the TLR4/ NF-κB pathway, thereby reducing neuropathic pain. Stigmasterol can be used for neurodegenerative diseases, inflammatory diseases, and pain management, among others .

HY-Y0966

Glycine Maximum Cited Publications 8 Publications Verification		Fillers
Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors. Glycine is orally active. Glycine can be used to study cell protection, cancer, neurological diseases, and angiogenesis .

HY-Y1316

Sodium benzoate 1 Publications Verification		Preservatives
Sodium benzoate is an orally active pharmaceutical excipient, such as an antibacterial agent, preservative, lubricant, etc. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs.Sodium benzoate activates NF-κB and induces Apoptosis. Sodium benzoate induces immune suppression and produces reproductively toxic. Sodium benzoate can be used for colon cancer and immune disease research .

HY-145721

Mongersen GED-0301		Antisense Oligonucleotides
Mongersen (GED-0301) is a specific and orally active SMAD7 antisense oligonucleotide. Mongersen restores TGF-β1 activity leading to inhibition of inflammatory signals. Mongersen can attenuate Crohn's disease-like experimental colitis in mice .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Oral diseases

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

NaturalProducts

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Natural
Products