2. MAPK/ERK Pathway NF-κB
  3. p38 MAPK NF-κB
  4. D-Psicose

D-psicose is an orally active rare sugar. D-psicose inhibits p38-MAPK phosphorylation and MCP-1 expression. D-psicose inhibits the AGEs/RAGE/NF-κB pathway. D-psicose protects pancreatic β-islets, improves hyperglycemia and high-fat diet-induced non-alcoholic fatty liver disease.

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D-Psicose

D-Psicose Chemical Structure

CAS No. : 551-68-8

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Based on 1 publication(s) in Google Scholar

Other Forms of D-Psicose:

D-Psicose Related Antibodies

Top Publications Citing Use of Products

View All p38 MAPK Isoform Specific Products:

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

View All NF-κB Isoform Specific Products:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

D-psicose is an orally active rare sugar. D-psicose inhibits p38-MAPK phosphorylation and MCP-1 expression. D-psicose inhibits the AGEs/RAGE/NF-κB pathway. D-psicose protects pancreatic β-islets, improves hyperglycemia and high-fat diet-induced non-alcoholic fatty liver disease[1][2][3][4][5].

In Vitro

D-Psicose (5.6-22.4 mM; 3-5 days) inhibits high-glucose-induced MCP-1 mRNA and protein expression in HUVECs by suppressing p38-MAPK phosphorylation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

D-Psicose Related Antibodies

Cell Viability Assay[1]

Cell Line: Human Umbilical Vein Endothelial Cells (HUVECs)
Concentration: 2.8 mM, 5.6 mM, 11.2 mM, 16.8 mM, 22.4 mM
Incubation Time: up to 5 days
Result: Dose-dependently reduced MCP-1 mRNA.
Showed no significant effect at 2.8 mM.
In Vivo

D-psicose (5%; p.o. via drinking water; 13 weeks) protects pancreas β-islets and thus improves insulin resistance in OLETF rats[2].
D-Psicose (200 mg/kg BW; p.o.; 28 days) ameliorates hyperglycemia, improves glucose tolerance, reduces hepatic triglyceride and total cholesterol levels by 37.88% and 62.89% respectively, and slows weight gain in C57BL/6J db/db mice[3].
D-Psicose (2.5%-5%; p.o. via drinking water; 12 weeks) reduces hepatic lipid accumulation and inflammatory damage, improves serum lipid profiles and oxidative stress, modulates gut microbiota (increases Akkermansia abundance) and serum metabolomics (enhances anti-inflammatory metabolites), and inhibits the AGEs/RAGE/NF-κB pathway in high-fat diet-induced NAFLD ICR mice[4].
D-Psicose (0.01%-1%; p.o. via diet; 6 weeks) shows no promoting or preventive effects on Diethylnitrosamine (HY-N7434)-induced hepatocarcinogenesis in F344 male rats[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Otsuka Long-Evans Tokushima Fatty (OLETF) rats (type 2 diabetes mellitus model)[2]
Dosage: 5% D-psicose
Administration: p.o. via drinking water; 13 weeks.
Result: Attenuated pancreatic β-islet fibrosis.
Preserved islet structure.
Reduced body weight and abdominal fat deposition.
Improves oral glucose tolerance and insulin resistance.
Molecular Weight

180.16

Formula

C6H12O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC[C@H]([C@H]([C@H](C(CO)=O)O)O)O
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (555.06 mM; Need ultrasonic)

DMSO : 100 mg/mL (555.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.5506 mL 27.7531 mL 55.5062 mL
5 mM 1.1101 mL 5.5506 mL 11.1012 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.89%

SDS (476 KB)

COA (246 KB) HNMR (115 KB) RP-HPLC (240 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 5.5506 mL 27.7531 mL 55.5062 mL 138.7655 mL
5 mM 1.1101 mL 5.5506 mL 11.1012 mL 27.7531 mL
10 mM 0.5551 mL 2.7753 mL 5.5506 mL 13.8766 mL
15 mM 0.3700 mL 1.8502 mL 3.7004 mL 9.2510 mL
20 mM 0.2775 mL 1.3877 mL 2.7753 mL 6.9383 mL
25 mM 0.2220 mL 1.1101 mL 2.2202 mL 5.5506 mL
30 mM 0.1850 mL 0.9251 mL 1.8502 mL 4.6255 mL
40 mM 0.1388 mL 0.6938 mL 1.3877 mL 3.4691 mL
50 mM 0.1110 mL 0.5551 mL 1.1101 mL 2.7753 mL
60 mM 0.0925 mL 0.4626 mL 0.9251 mL 2.3128 mL
80 mM 0.0694 mL 0.3469 mL 0.6938 mL 1.7346 mL
100 mM 0.0555 mL 0.2775 mL 0.5551 mL 1.3877 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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D-Psicose Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

D-Psicose551-68-8p38 MAPKNF-κBNuclear factor-κBNuclear factor-kappaBNAFLDICR mice ratshyperglycemiaInhibitorinhibitorinhibit

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